Theramid DERMA-PEPTIDES for skin with dark spots
Palmitoyl Tripeptide-1
Sh-Oligopeptide-1
Palmitoyl Tetrapeptide-7
Average
- HighNormal Skin Fit
- AverageEffectiveness
- HighSafety
Works for skin with dark spots; other moisturizers fit it better.
This fit is calculated for the concerns frequently associated with dark spots: hyperpigmentation, sun spots, and uneven skin tone. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Suitable for normal skin, this product utilizes Palmitoyl Tripeptide-1 and Sh-Oligopeptide-1 to support collagen stimulation and extracellular matrix synthesis, which is beneficial for overall skin health.
- Glycerin and Propanediol offer moderate moisturizing benefits, but these ingredients do not directly address your main goal of pigmentation.
- The product is safe for your normal skin, as it lacks prohibited or harsh ingredients and poses no risk of irritation.
How to apply
- Could be used as part of your AM and PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply this moisturizer after your cleanser and toner, right before your morning SPF.
- Gently press a small amount of the moisturizer into your skin. Avoid rubbing it too hard so it absorbs nicely.
- For the best moisture, you can apply it when your skin is slightly damp. This helps your skin stay soft and happy.
- Remember to avoid the eye area when applying. Always do a patch test before your first use.
People Say
★4.7Overall rating based on 300+ reviewsUsers frequently praise this serum for its lightweight, non-sticky texture and its effectiveness in delivering visible anti-aging results, such as increased skin plumpness and reduced fine lines. It is also noted for its gentle, fragrance-free formulation, making it suitable for sensitive skin and compatible with other active ingredients.
Highlights
Visible anti-aging Mostly Mentioned
- “Fine lines are less visible”
- “Skin looks plumper”
- “More youthful skin”
Gentle formulation Often Mentioned
- “Suitable for sensitive skin”
- “No strong scent”
- “No sensitising occurring”
Lightweight texture Often Mentioned
- “Absorbs quickly”
- “Doesn't leave stickiness”
- “Lotion-like texture”
Good value Sometimes Noted
- “Price is unbeatable”
- “Affordable serums”
- “Quality for price”
Practical packaging Sometimes Noted
- “Love the pump”
- “Pipettes are annoying”
- “Packaging pleases senses”
High expectations Rarely Noted
- “Overhyped by influencers”
- “Waiting for results”
- “Not a miracle”
Limited availability Rarely Noted
- “Hard to find in stores”
- “Only online”
- “Shipping delays”
Packaging preference Rarely Noted
- “Prefer glass bottles”
- “Pump can clog”
- “Hard to see level”
Sources: lovi.care, nichebeautylab.com, skintskincare.com, reddit.com, youtube.com, and more
Questions and answers
How well does Theramid Derma-Peptides work for skin with dark spots?
Theramid Derma-Peptides works for skin with dark spots only moderately well, because its peptides support collagen and overall skin health while glycerin and propanediol provide moderate moisture rather than directly fading dark spots. A product of this type needs hydrating and soothing ingredients that safely address pigmentation concerns while maintaining the skin barrier.
Journal of Cosmetic Dermatology, 2026International Journal of Cosmetic Science, 2026
Which ingredients make this treatment a good fit for skin with dark spots?
Palmitoyl Tripeptide-1, Sh-Oligopeptide-1, and Palmitoyl Tetrapeptide-7 are unlikely to directly fade dark spots, though they support overall skin health. A treatment for this skin needs ingredients that safely address pigmentation concerns with hydrating and soothing benefits.
Journal of Cosmetic Dermatology, 2026International Journal of Cosmetic Science, 2026
What does Palmitoyl Tripeptide-1 do for skin with dark spots?
Palmitoyl tripeptide-1 helps improve skin firmness and targets signs of aging, but it is primarily paired with other ingredients like baicalin for daytime luminance rather than fading dark spots directly.
What does EGF do for skin with dark spots?
Epidermal growth factor may help fade dark spots on some skin types, but results vary depending on the treatment and individual skin response. While some studies show it can help reduce dark spots and prevent discoloration after procedures, other research finds no significant difference compared to standard care.
Where does this treatment go in a skincare routine for skin with dark spots?
This treatment goes in the evening routine before your moisturizer for simplicity and extra safety around sun exposure. It helps support overall skin health and provides moderate moisture, though fading dark spots requires a product that specifically targets pigmentation with brightening ingredients.
Can I use this treatment with retinol, and in what order?
You can use this treatment alongside retinol, applying the treatment first and following with retinol, or using this treatment in the morning and retinol at night. It is safe for your skin and poses no risk of irritation, though skin with dark spots needs dedicated brightening ingredients to effectively target pigmentation.
How often should I use this treatment?
Apply this treatment in the evening as part of your nighttime routine. This helps keep things simple and avoids extra safety concerns around sun exposure.
Can this treatment clog pores, cause breakouts or purging for skin with dark spots?
This treatment is unlikely to clog pores or cause breakouts for skin with dark spots, as it lacks harsh ingredients and poses no risk of irritation. A product of this type for skin with dark spots needs targeted brightening ingredients that directly address pigmentation alongside its moisturizing benefits.
Can I use this treatment around the eyes or on my body?
Yes, you can use this moisturizing treatment around your eyes and on your body because its gentle formula is safe and unlikely to cause irritation.
What the research says
Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants.
Journal of Cosmetic Dermatology, 2026Palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-10 significantly increased type III collagen levels in human dermal fibroblasts following UV exposure, with their combination demonstrating a greater effect in vitro and enhancing type I, III, and IV collagen levels in ex vivo skin tissues compared to individual components.
International Journal of Cosmetic Science, 2026A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo.
Journal of Cosmetic Dermatology, 2015Topical application of 1,3-propanediol at various concentrations, alone or combined with butylene glycol and/or glycerol, increased skin hydration and reduced trans epidermal water loss in 30 healthy female subjects over an 8-hour period, with the 15% concentration and the addition of glycerol providing greater benefits.
International Journal of Cosmetic Science, 2024A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Topical epidermal growth factor combined with silver sulfadiazine accelerated the rate of epidermal regeneration and significantly decreased healing time by approximately 1 to 1.5 days across all stages of healing in skin-graft-donor sites of 12 patients compared to silver sulfadiazine alone.
The New England Journal of Medicine, 1989Topical recombinant human epidermal growth factor combined with ablative fractional carbon dioxide laser significantly improved striae surface texture and showed significantly greater participant satisfaction regarding marked improvement compared to ablative fractional carbon dioxide laser combined with Aloe vera gel in patients with striae alba.
Lasers in Surgery and Medicine, 2020Topical EGF combined with fractional CO2 laser significantly improves the clinical appearance of atrophic acne scars and decreases skin pigmentation compared to fractional CO2 laser alone in patients with atrophic acne scars.
The Journal of Clinical and Aesthetic Dermatology, 2022
Ingredients
Water, Glycerin, Propanediol, Caprylic Capric Triglyceride, Palmitoyl Tripeptide-1, Sh-Oligopeptide-1, Palmitoyl Tetrapeptide-7
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
-
Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
-
Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
-
Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
-
Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
-
Medical Board
Cosmetic chemist, SCS, IFSCC member
-
Medical Board, Medical Advisor
Dermatology MD
-
Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
-
Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
Scan your face, then any product: Lovi shows how well it fits you and what fits even better.