Theramid Copper Peptide for mature skin
Copper Tripeptide-1
Acetyl Tetrapeptide-2
Sodium Hyaluronate
Bifida Lysate Ferment
Acetyl Glutamine
High
- HighNormal Skin Fit
- AverageEffectiveness
- HighSafety
A great choice for mature skin; a few serums fit it even better.
This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- This product offers excellent skin repair and anti-aging benefits for your normal skin, with copper tripeptide-1 and acetyl hexapeptide-1 actively working to smooth fine lines and wrinkles.
- While sodium hyaluronate provides essential hydration, the formula's primary focus is on repair rather than directly targeting your main concern of wrinkles and fine lines.
- The product is safe for your normal skin, as it contains no harsh ingredients and poses no risk of irritation.
How to apply
- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
People Say
★4.4Overall rating based on 100+ reviewsA lightweight, fast-absorbing texture is frequently praised, and a moderate number of users report a boost in skin radiance. Some users find the high silicone content problematic for layering and note that copper peptides require careful routine planning to avoid conflicts with other active ingredients.
Highlights
Improves firmness Often Mentioned
- “my skin feels incredibly fed and plump”
- “improving skin elasticity and firmness”
- “it felt bouncier and more lifted”
- “helps to improve signs of aging... firm, smooth, radiant, and younger-looking skin”
Lightweight, fast-absorbing Often Mentioned
- “the texture is a sophisticated, lightweight gel that absorbs almost instantly without leaving a sticky residue”
- “absorbs quickly, and doesn't leave any stickiness, which is a huge plus for those of us who prefer to layer products”
- “it feels better on my skin... soaks in much better”
- “light, gel-like consistency absorbs quickly without leaving a tacky residue”
Boosts radiance Sometimes Noted
- “instantly gives the skin a radiant glow and freshness”
- “my skin has gotten a lot brighter and a lot better”
- “helps my complexion look lively”
- “promote a more youthful glow”
Gentle, non-irritating Sometimes Noted
- “incredibly gentle... I experienced zero redness or irritation”
- “I experienced no redness or dryness, which is often a concern when introducing strong active ingredients”
- “perfect for beginners, sensitive skin”
Hard to combine Sometimes Noted
- “copper peptides are high maintenance... you really don't want to use it in with anything that has a low pH”
- “I wouldn't recommend using it together with Niactilen”
- “Do not use with other acids and retinol products”
High silicone content Rarely Noted
- “I don't like the fact that is has so much silicone in it”
- “makes it very difficult to rub on the skin, because it 'sticks' to first place you put it and doesn't blend well”
- “This broke me out on my face”
No visible results Rarely Noted
- “Nearly 2 months in, no result”
- “No Effect”
- “I have it, I can't say how effective it is”
Sources: lovi.care, peptides133.com, peptides136.com, peptides138.com, youtube.com, lyko.com, and more
Questions and answers
What makes Theramid Copper Peptide for Mature Skin such a great fit?
This product is a great fit because it offers strong skin repair and anti-aging benefits for mature skin, with copper tripeptide-1 and acetyl hexapeptide-1 working to smooth fine lines and wrinkles. It also includes sodium hyaluronate to provide essential hydration while remaining safe and unlikely to cause irritation.
Which ingredients make this serum a good fit for mature skin?
Copper tripeptide-1 and acetyl hexapeptide-1 make this serum a great fit for mature skin by helping to smooth fine lines and wrinkles. They work alongside sodium hyaluronate to repair your skin and keep it safely hydrated without irritation.
What does Copper Tripeptide-1 do for mature skin?
Copper Tripeptide-1 helps improve mature skin by smoothing out fine lines and wrinkles while boosting firmness and elasticity. It also helps calm irritation, protects against daily damage, and supports a stronger skin barrier.
Journal of Biomaterials Science. Polymer Edition, 2008Skin Research and Technology, 2026
What does Acetyl Tetrapeptide-2 do for mature skin?
Acetyl Tetrapeptide-2 helps mature skin by increasing cell firmness and supporting overall skin structure. It is a common ingredient in anti-aging routines designed to keep skin looking tight and resilient.
International Journal of Peptide Research and Therapeutics, 2018
Where does this serum go in a skincare routine for mature skin?
This treatment serum goes in the evening routine after cleansing and before moisturizing, keeping it simple and safe around sun exposure. It helps smooth fine lines and repair mature skin with copper tripeptide-1 and acetyl hexapeptide-1 while being safe and unlikely to cause irritation.
Can I use this serum with retinol, and in what order?
You can use this serum with retinol by applying your retinol product first and following with this treatment in your evening routine. This helps smooth fine lines while minimizing the likelihood of irritation.
How often should I use this serum?
Apply this treatment in the evening, following your cleanser and toner. It is a great fit for mature skin and helps smooth fine lines and wrinkles while being very safe to use.
Can this serum clog pores, cause breakouts or purging for mature skin?
This serum is unlikely to clog pores, cause breakouts, or lead to purging on mature skin. It has a safe profile with no harsh ingredients, making it very gentle for daily use.
Is this serum fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
The combination of Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract and copper tripeptide-1 GHK-Cu reduced inflammatory cytokines, protected skin explants from UV-induced damage, and improved wrinkles and skin barrier conditions compared to individual components or controls.
Skin Research and Technology, 2026Hyaluronic acid extracts are safe and efficacious products for skin repair when used in tissue regeneration alone or in combination with herbal or Western medicine.
Journal of Pharmacy & Pharmaceutical Sciences, 2015Topical copper tripeptide complex on CO2 laser-resurfaced skin caused no significant reduction in erythema or objective improvement in wrinkles compared to controls, but significantly increased patient satisfaction regarding overall skin quality.
Archives of Facial Plastic Surgery, 2006A novel regimen combining a hydroxy acid-based scrub and copper tripeptide serum significantly reduced adherent scalp flaking by 61.24%, increased hair density by 12.48%, increased hair thickness by 25.36%, and improved scalp skin hydration by 76.24% in adults with mild to moderate dandruff over 15 days.
Cureus, 2024Copper applied transdermally as a tripeptide on human skin ex vivo permeated the tissue and was retained in amounts potentially effective for treating inflammatory diseases.
Inflammation Research, 2010Treatment of immortalized human keratinocytes with Acetyl Tetrapeptide-2 increased cell stiffness across its concentration range, while Acetyl Hexapeptide-50 increased stiffness at 0.05 µg/ml but decreased it at 0.5 and 5 µg/ml compared to untreated controls.
International Journal of Peptide Research and Therapeutics, 2018Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.
Journal of Drugs in Dermatology, 2011Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.
Clinical Oral Investigations, 2022Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.
BMC Oral Health, 2019Topical application of Bifida Ferment Lysate strengthens the skin barrier function by upregulating barrier and antimicrobial peptide genes, exhibiting strong antioxidant properties, and decreasing inflammatory cytokine secretion in vitro.
Journal of Cosmetic Dermatology, 2023
Ingredients
Water, Propanediol, Cyclopentasiloxane, Dimethicone, Betaine, Copper Tripeptide-1, Bifida Lysate Ferment, Cyclohexasiloxane, Glycerin, Sodium Chloride, Polyglyceryl-4 Isostearate, Sodium Hyaluronate, Acetyl Tetrapeptide-2, Trifluoroacetyl Tripeptide-2, Sh-Oligopeptide-1, Sh-Oligopeptide-2, Sh-Polypeptide-1, Sh-Polypeptide-11, Sh-Polypeptide-9, Acetyl Hexapeptide-1, Bacillus Folic Acid Extract Ferment Filtrate, Cetyl Peg Ppg-10 1 Dimethicone, Hexyl Laurate, Peg Ppg-18 18 Dimethicone, Lecithin, Acetyl Glutamine, Caprylyl Glycol, Butylene Glycol, Dextran, Disodium Edta, Acetic Acid, Lactic Acid, 1,2-Hexanediol, Sodium Benzoate, Phenoxyethanol
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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