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Perricone MD Deep Crease Serum for skin with dark spots

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes

Perricone MD Deep Crease Serum

Average

  • HighNormal Skin Fit
  • AverageEffectiveness
  • HighSafety

Works for skin with dark spots; other serums fit it better.

This fit is calculated for the concerns frequently associated with dark spots: hyperpigmentation, sun spots, and uneven skin tone. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.

Page built Nov 8, 2026How the Fit score works

Lovi Assistant explains

  • Offers excellent wrinkle reduction for your normal skin due to Palmitoyl Tripeptide-5 and Acetyl Hexapeptide-8, which plump and minimize fine lines, while S-Palmitoylglutathione and Tetrahexyldecyl Ascorbate provide antioxidant and barrier repair benefits.
  • Glycerin and Tocopherol offer general hydration and soothing effects, supporting your skin's overall health.
  • The product is safe for your normal skin, with no risks of irritation from harsh ingredients.

How to apply

  • Apply this serum as part of your PM routine starting 3x/week and build up to daily use if your skin likes it.
  • Place the serum after cleansing and toning, but before your moisturizer.
  • Gently press 2-3 drops of the serum into your skin and wait a minute for it to absorb.
  • Apply the serum on dry skin to help fade pigmentation effectively.
  • Avoid the eye area and always use SPF 30+ during the day.

People Say

★4.5Overall rating based on 800+ reviews

Users in their 40s and 50s frequently praise this serum for its lightweight, non-greasy feel and its ability to hydrate and soften the appearance of expression lines. While results are gradual, consistent use leads to firmer, smoother-looking skin.

Highlights

  • Lightweight texture Mostly Mentioned
    • “Absorbs quickly”
    • “not sticky or greasy”
    • “feels silky and smooth”
  • Hydrating formula Often Mentioned
    • “Skin drinks it up”
    • “leaves skin feeling plump”
    • “adds a boost of moisture”
  • Softens deep lines Often Mentioned
    • “Deeper lines look softer”
    • “smile lines appear less pronounced”
    • “frown lines look less visible”
  • High price point Often Mentioned
    • “Price is quite premium”
    • “barrier for some”
    • “expensive investment”
  • Improves firmness Sometimes Noted
    • “Skin feeling firmer”
    • “noticeable improvement in bounce”
    • “more lifted look”
  • Dropper issues Sometimes Noted
    • “Difficult to pick up product”
    • “dropper doesn't work well”
    • “inconsistent dispensing”
  • Gradual results Sometimes Noted
    • “Not an overnight miracle”
    • “results are subtle”
    • “haven't seen 11s improve yet”
  • Fragrance sensitivity Rarely Noted
    • “Rose scent may not be ideal”
    • “not for those with fragrance allergies”

Sources: lovi.care, perriconemd.com, dermstore.com, ulta.com, youtube.com, reddit.com, and more

Questions and answers

How well does Perricone MD Deep Crease Serum work for skin with dark spots?

Perricone MD Deep Crease Serum works for skin with dark spots, though other products fit this skin better. Treatments that rate higher for dark spots need a blend of effective antioxidants and soothing ingredients that provide significant benefits for pigmentation concerns without any risk of irritation.

Which ingredients make this serum a good fit for skin with dark spots?

This serum works for skin with dark spots because it contains Tetrahexyldecyl Ascorbate, which helps brighten the skin and fade discoloration. A treatment for this skin needs a blend of effective antioxidants and soothing ingredients that target pigmentation safely without causing irritation.

What does Acyl-Glutathione do for skin with dark spots?

Acyl-Glutathione helps fade dark spots and brightens your overall skin tone while smoothing out the surface. This ingredient has a safe profile and works by improving pigmentation, though individual results may vary.

The Journal of Clinical and Aesthetic Dermatology, 2025Molecules, 2026

What does Palmitoyl Glutathione do for skin with dark spots?

Palmitoyl glutathione helps brighten skin and fade dark spots with a good safety profile when applied topically. This type of ingredient needs to be paired with antioxidants and brightening agents to effectively improve uneven skin tone.

Indian Journal of Dermatology, Venereology and Leprology, 2016Dermatology Practical & Conceptual, 2018

Where does this serum go in a skincare routine for skin with dark spots?

This treatment goes in the evening routine, applied after cleansing and before moisturizing. Products for this skin need vitamin C, alpha arbutin, niacinamide, or retinoids to fade dark spots effectively.

Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying your retinol first, letting it absorb, and then following with this treatment to keep your skin smooth and calm. This product works for your skin, though an average fit for skin with dark spots needs brightening ingredients and antioxidants to target uneven tone effectively.

How often should I use this serum?

This treatment serum works well in the evening as part of your routine for skin with dark spots, though skin with dark spots typically needs targeted brightening ingredients like vitamin C or niacinamide to help fade discoloration effectively.

Can this serum clog pores, cause breakouts or purging for skin with dark spots?

This serum is unlikely to clog pores or cause breakouts on your skin with dark spots, as it lacks heavy, pore-clogging oils. However, to truly fade dark spots and even out skin tone, this skin type needs targeted brightening ingredients like vitamin C derivatives, niacinamide, or gentle exfoliating acids.

Is this serum fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (parfum, citronellol, limonene, and linalool).

What the research says

  • Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group.

    American Journal of Clinical Dermatology, 2013

  • Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects.

    Journal of Cosmetic and Laser Therapy, 2013

  • Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days.

    Annals of Dermatology, 2019

  • A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

    Clinical, Cosmetic and Investigational Dermatology, 2017

  • A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers.

    Journal of Cosmetic Dermatology, 2020

  • Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls.

    Journal of the European Academy of Dermatology and Venereology, 2024

  • Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women.

    Clinical, Cosmetic and Investigational Dermatology, 2014

  • Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity.

    The Journal of Clinical and Aesthetic Dermatology, 2025

  • Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers.

    Experimental Dermatology, 2003

  • Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation.

    Journal of Periodontology, 2009

  • Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream.

    Journal of Cosmetic Dermatology, 2022

  • Supramolecular collagen nanoparticles composed of lactoferrin, recombinant human collagen, and palmitoyl tripeptide-5 improved transdermal efficiency by 69.90% and demonstrated moisturizing, whitening, wrinkle reduction, and firming effects.

    Colloids and Surfaces. B, Biointerfaces, 2025

  • Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear.

    Journal of Cosmetic Dermatology, 2017

  • Daily topical acetyl hexapeptide-8 showed a trend toward a longer time until return to baseline Jankovic Blepharospasm Rating Scale scores compared to placebo (3.7 months vs. 3.0 months) in 24 patients with blepharospasm receiving botulinum toxin therapy.

    European Journal of Neurology, 2013

  • Dissolving microneedles loaded with 3-O-ethyl ascorbic acid and acetyl hexapeptide-8 achieved higher cumulative transdermal delivery than aqueous solutions and significantly reduced photoaging signs while restoring oxidative balance in a UV/D-galactose-induced mouse model.

    International Journal of Biological Macromolecules, 2026

Why other serums fit skin with dark spots better

Ingredients

Water, Propanediol, Squalane, Hydrogenated Polyisobutene, S-Palmitoylglutathione, Dimethicone, Glycerin, Macadamia Ternifolia Seed Oil, Xylitylglucoside, Tetrahexyldecyl Ascorbate, Dimethyl Mea, Palmitoyl Tripeptide-5, Acetyl Hexapeptide-8, Anhydroxylitol, Lactic Acid, Xylitol, Xanthan Gum, Linum Usitatissimum Seed Oil, Salvia Hispanica Seed Oil, Tocopherol, Ethylhexylglycerin, Magnesium Aspartate, Zinc Gluconate, Alaria Esculenta Extract, Glucose, Sodium Hyaluronate, Copper Gluconate, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Helianthus Annuus Seed Oil Sunflower Seed Oil, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Tetrasodium Glutamate Diacetate, Magnesium Chloride, Caprylic Capric Triglyceride, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Caprylyl Capryl Glucoside, Caprylyl Glycol, Potassium Sorbate, Phenoxyethanol, Parfum, Citronellol, Hydroxycitronellal, Limonene, Linalool

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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How does it fit your skin?

Scan your face, then any product: Lovi shows how well it fits you and what fits even better.

QR code: get the Lovi app
Download on theApp Store Get it onGoogle Play