Perricone MD Deep Crease Serum for acne-prone skin
Acyl-Glutathione- S-Palmitoylglutathione
Tetrahexyldecyl Ascorbate
Palmitoyl Tripeptide-5
Acetyl Hexapeptide-8
Average
- AverageCombination Skin Fit
- AverageEffectiveness
- HighSafety
Works for acne-prone skin; other serums fit it better.
- Clinical, Cosmetic and Investigational Dermatology, 2017
- American Journal of Clinical Dermatology, 2013
This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate suitability for your combination skin, as squalane and glycerin provide emollient and humectant actions to support hydration, though it may not fully address oilier zones.
- The formulation provides excellent wrinkle reduction due to palmitoyl tripeptide-5 and acetyl hexapeptide-8, which plump and minimize fine lines and wrinkles.
- The safety profile is excellent, with no risks of irritation for your combination skin due to the absence of prohibited or harsh ingredients.
How to apply
- Use your serum as part of your PM routine and start 3x/week before working up to daily use.
- Apply this treatment after cleansing and toner, and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the product on clean, dry skin to help manage your breakouts safely.
- Avoid the eye area and do a patch test before your first use.
People Say
★4.5Overall rating based on 800+ reviewsUsers in their 40s and 50s frequently praise this serum for its lightweight, non-greasy feel and its ability to hydrate and soften the appearance of expression lines. While results are gradual, consistent use leads to firmer, smoother-looking skin.
Highlights
Lightweight texture Mostly Mentioned
- “Absorbs quickly”
- “not sticky or greasy”
- “feels silky and smooth”
Hydrating formula Often Mentioned
- “Skin drinks it up”
- “leaves skin feeling plump”
- “adds a boost of moisture”
Softens deep lines Often Mentioned
- “Deeper lines look softer”
- “smile lines appear less pronounced”
- “frown lines look less visible”
High price point Often Mentioned
- “Price is quite premium”
- “barrier for some”
- “expensive investment”
Improves firmness Sometimes Noted
- “Skin feeling firmer”
- “noticeable improvement in bounce”
- “more lifted look”
Dropper issues Sometimes Noted
- “Difficult to pick up product”
- “dropper doesn't work well”
- “inconsistent dispensing”
Gradual results Sometimes Noted
- “Not an overnight miracle”
- “results are subtle”
- “haven't seen 11s improve yet”
Fragrance sensitivity Rarely Noted
- “Rose scent may not be ideal”
- “not for those with fragrance allergies”
Sources: lovi.care, perriconemd.com, dermstore.com, ulta.com, youtube.com, reddit.com, and more
Questions and answers
How well does Perricone MD Deep Crease Serum work for acne-prone skin?
Perricone MD Deep Crease Serum works for acne-prone skin, though other products fit it better because they target breakouts more directly. An acne-prone skin treatment of this type needs ingredients like niacinamide, propolis, or zinc PCA to help clear blemishes and control oiliness while keeping the skin balanced.
Which ingredients make this serum a good fit for acne-prone skin?
This serum works for acne-prone skin, though other products fit it better because they contain ingredients like niacinamide, zinc PCA, and propolis that manage breakouts while balancing hydration and oiliness.
What does Acyl-Glutathione do for acne-prone skin?
Acyl-Glutathione helps support antioxidant defense and calm skin, but acne-prone skin typically needs ingredients that clear pores and reduce breakouts.
What does Palmitoyl Glutathione do for acne-prone skin?
Palmitoyl glutathione helps support acne-prone skin by providing antioxidant protection that may calm the skin and keep it healthy. This type of skin needs ingredients that reduce redness and maintain a balanced surface without clogging pores.
Where does this serum go in a skincare routine for acne-prone skin?
This treatment goes in your evening routine, after cleansing and toning and before moisturizing, to keep things simple and safe around sun exposure. Acne-prone skin works best with lighter, oil-free hydrators and gentle blemish-clearing ingredients that won't clog pores.
Can I use this serum with retinol, and in what order?
You can use this serum with retinol by applying your retinol first at night, letting it absorb, and then following with this treatment. This product works for your skin, though an acne-prone skin type needs lightweight, oil-balancing ingredients that clear breakouts while supporting hydration.
How often should I use this serum?
You can use this treatment in the evening as part of your routine. This product works for your acne-prone skin, though this skin type needs lightweight hydrating ingredients and gentle blemish-balancing components to get the best results.
Can this serum clog pores, cause breakouts or purging for acne-prone skin?
This serum is unlikely to cause irritation for your acne-prone skin, but it works only moderately well since its oils may not fully balance oilier zones. A product of this type for acne-prone skin needs lightweight hydration and soothing ingredients that help keep pores clear while smoothing lines.
Is this serum fragrance-free and alcohol-free?
It has no drying alcohol and contains fragrance (parfum, citronellol, limonene, and linalool).
What the research says
A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group.
American Journal of Clinical Dermatology, 2013Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days.
Annals of Dermatology, 2019Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear.
Journal of Cosmetic Dermatology, 2017Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls.
Journal of the European Academy of Dermatology and Venereology, 2024Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2014Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity.
The Journal of Clinical and Aesthetic Dermatology, 2025Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers.
Experimental Dermatology, 2003Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation.
Journal of Periodontology, 2009Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream.
Journal of Cosmetic Dermatology, 2022Supramolecular collagen nanoparticles composed of lactoferrin, recombinant human collagen, and palmitoyl tripeptide-5 improved transdermal efficiency by 69.90% and demonstrated moisturizing, whitening, wrinkle reduction, and firming effects.
Colloids and Surfaces. B, Biointerfaces, 2025Daily topical acetyl hexapeptide-8 showed a trend toward a longer time until return to baseline Jankovic Blepharospasm Rating Scale scores compared to placebo (3.7 months vs. 3.0 months) in 24 patients with blepharospasm receiving botulinum toxin therapy.
European Journal of Neurology, 2013Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects.
Journal of Cosmetic and Laser Therapy, 2013Dissolving microneedles loaded with 3-O-ethyl ascorbic acid and acetyl hexapeptide-8 achieved higher cumulative transdermal delivery than aqueous solutions and significantly reduced photoaging signs while restoring oxidative balance in a UV/D-galactose-induced mouse model.
International Journal of Biological Macromolecules, 2026
Why other serums fit acne-prone skin better
A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions.
Journal of Cosmetic Dermatology, 2024A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo.
Clinical Pharmacology, 2018Topical nicotinamide plus an antibacterial adhesive agent and zinc-pyrrolidone carboxylic acid combined with adapalene significantly reduced noninflammatory acne lesions by the second week of therapy compared to placebo with adapalene in patients with moderate acne vulgaris.
The Journal of Clinical and Aesthetic Dermatology, 2020
Ingredients
Water, Propanediol, Squalane, Hydrogenated Polyisobutene, S-Palmitoylglutathione, Dimethicone, Glycerin, Macadamia Ternifolia Seed Oil, Xylitylglucoside, Tetrahexyldecyl Ascorbate, Dimethyl Mea, Palmitoyl Tripeptide-5, Acetyl Hexapeptide-8, Anhydroxylitol, Lactic Acid, Xylitol, Xanthan Gum, Linum Usitatissimum Seed Oil, Salvia Hispanica Seed Oil, Tocopherol, Ethylhexylglycerin, Magnesium Aspartate, Zinc Gluconate, Alaria Esculenta Extract, Glucose, Sodium Hyaluronate, Copper Gluconate, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Helianthus Annuus Seed Oil Sunflower Seed Oil, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Tetrasodium Glutamate Diacetate, Magnesium Chloride, Caprylic Capric Triglyceride, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Caprylyl Capryl Glucoside, Caprylyl Glycol, Potassium Sorbate, Phenoxyethanol, Parfum, Citronellol, Hydroxycitronellal, Limonene, Linalool
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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