🇮🇪Ireland

Medicube Zero Exosome Shot for dry skin

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes

Medicube Zero Exosome Shot

Average

  • AverageDry Skin Fit
  • AverageEffectiveness
  • HighSafety

Works for dry skin; other serums fit it better.

This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.

Page built Nov 8, 2026How the Fit score works

Lovi Assistant explains

  • Offers moderate suitability for your dry skin, as glycerin and panthenol provide humectant action to support hydration, but the formula lacks sufficient emollients and occlusives for optimal moisture retention.
  • Niacinamide and gluconolactone offer benefits for evening skin tone and smoothing texture, which are generally helpful for your skin.
  • The product is safe for your dry skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

How to apply

  • Apply this serum PM, starting 3×/week and working up to daily use as your skin adjusts.
  • Place the serum after cleansing and toner, but right before your moisturizer.
  • Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
  • Apply the serum on slightly damp skin to help lock in extra moisture.
  • Avoid the eye area and do a patch test before your first use.

People Say

★4.7Overall rating based on 100+ reviews

Users describe this ampoule as a potent texturizing treatment that delivers a glass skin finish by minimizing pores and smoothing roughness. While highly effective for many in tightening pores and boosting radiance, the sensation is polarizing, often described as a prickly or tingling feeling that can be intense for sensitive skin.

Highlights

  • Smoother texture Mostly Mentioned
    • “bumpy texture is finally smooth”
    • “skin feels silky smooth”
    • “makeup glides on easier”
    • “glass-like skin”
  • Prickly sensation Mostly Mentioned
    • “feels like fiberglass”
    • “stinging all over”
    • “uncomfortable prickly feel”
    • “like tiny needles poking”
  • Pore minimization Often Mentioned
    • “black dots on my nose have all but disappeared”
    • “pores are the smallest they've ever been”
    • “immediate and certain pore tightening”
    • “pores looked teeny tiny”
  • Radiance and glow Often Mentioned
    • “radiates with a healthy glow”
    • “skin looked noticeably brighter”
    • “complexion looks clearer”
  • Enhanced absorption Sometimes Noted
    • “makes all my serums work better”
    • “acts as a pathway to enhance absorption”
    • “products sink in deeper”
  • Skin irritation Sometimes Noted
    • “led to redness and breakouts”
    • “left me feeling raw”
    • “too intense for sensitive skin”
    • “caused irritation”
  • Lack of results Rarely Noted
    • “skin looking the exact same”
    • “didn't really work for me”
    • “not sure what exactly this is doing”
  • Unpleasant texture Rarely Noted
    • “sticky after-feel”
    • “heavy on sensitive skin”
    • “feels a bit tacky”

Sources: lovi.care, stylekorean.com, skinsort.com, medicube.us, instyle.com, newbeauty.com, and more

Questions and answers

How well does Zero Exosome Shot work for dry skin?

MEDICUBE Zero Exosome Shot offers moderate suitability for dry skin, as glycerin and panthenol provide hydration, but the formula lacks sufficient richer softening and sealing ingredients for optimal moisture retention. A treatment of this type needs rich softening ingredients, ceramides, peptides, and extra moisture-locking components to fully support and nourish dry skin.

Clinical, Cosmetic and Investigational Dermatology, 2017The Journal of Dermatological Treatment, 2017

Which ingredients make this treatment a good fit for dry skin?

Glycerin, panthenol, niacinamide, and gluconolactone help support hydration and smooth texture for your dry skin. However, since this is an average fit, dry skin needs products with rich emollients, occlusives, ceramides, and soothing ingredients like propolis or botanical extracts for optimal moisture retention and barrier support.

Clinical, Cosmetic and Investigational Dermatology, 2017The Journal of Dermatological Treatment, 2017

What does Lacto Exosome do for dry skin?

Lacto Exosome helps dry skin by strengthening the skin barrier so it stays soft and holds onto moisture better. It supports key proteins that keep your skin smooth and protected against everyday dryness.

Clinical, Cosmetic and Investigational Dermatology, 2025

What does Niacinamide do for dry skin?

Niacinamide helps dry skin by strengthening the skin barrier, increasing hydration, and reducing water loss. It supports ceramide production and helps keep the surface smooth and calm. This ingredient tends to be very well tolerated and is unlikely to irritate dry skin.

Journal of Cosmetic Dermatology, 2004Journal of Cosmetic Dermatology, 2026

Where does this treatment go in a skincare routine for dry skin?

This treatment goes in the evening routine after cleansing and before moisturizing, used once a week to start. A product of this type needs richer rich creams and heavy oils to lock in moisture for dry skin.

Can I use this treatment with retinol, and in what order?

You can use this treatment alongside retinol by applying it before your retinol at night, provided your skin is not sensitive. Because dry skin needs extra care, a product of this type needs rich smoothing ingredients and heavy oils to lock in moisture.

How often should I use this treatment?

Use this treatment in your evening routine once a week to start, and if your skin feels comfortable and tolerates it well, you may carefully use it more often. A product of this type needs rich creams and heavier oils to lock in hydration and keep dry skin feeling soft and smooth.

Can this treatment clog pores, cause breakouts or purging for dry skin?

This treatment is unlikely to clog pores or cause breakouts on dry skin, and it poses no risk of irritation from harsh ingredients. To better fit dry skin, a product of this type needs richer emollients and occlusives to lock in moisture.

Is this treatment fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

What the research says

  • A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

    Clinical, Cosmetic and Investigational Dermatology, 2017

  • A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability.

    The Journal of Dermatological Treatment, 2017

  • Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment.

    American Journal of Clinical Dermatology, 2002

  • Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer.

    The British Journal of Dermatology, 2002

  • Lactobacillus-derived exosome therapy combined with microneedling reduced acne severity, post-inflammatory hyperpigmentation, and atrophic scarring in three patients, with high satisfaction and minimal adverse effects.

    The Journal of Craniofacial Surgery, 2025

  • Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

    Journal of Cosmetic Dermatology, 2021

  • Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

    The Journal of Investigative Dermatology, 2008

  • Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

    Dermatologic Surgery, 2005

  • Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months.

    The Journal of Dermatology, 2008

  • Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants.

    International Journal of Molecular Sciences, 2026

  • Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts.

    International Journal of Molecular Sciences, 2021

  • A nano-encapsulated spicule system delivering Wharton's Jelly MSC secretome enhanced transdermal penetration, promoted cell proliferation and collagen synthesis in vitro, and reduced wrinkles and pigmentation in clinical evaluation.

    International Journal of Molecular Sciences, 2025

  • Deer antler velvet extract formulated in sponge spicule micro-blend cream applied to healthy humans for 14 days enhanced macromolecule skin permeation by 1.94-fold, decreased melanin content and erythema, and increased skin elasticity and hydration without causing irritation.

    Biological & Pharmaceutical Bulletin, 2019

  • Marine sponge spicules enhanced the skin delivery of human umbilical cord-derived mesenchymal stem cell exosomes by a factor of 5.87 and combined with them produced significant anti-photoaging effects in mice compared to exosomes alone.

    International Journal of Nanomedicine, 2020

Why other serums fit dry skin better

Ingredients

Water, Dipropylene Glycol, Glycerin, Butylene Glycol, 1,2-Hexanediol, Niacinamide, Sodium Polyacrylate, Ethylhexyl Palmitate, Hydrolyzed Sponge, C12-14 Alketh-12, Hydrogenated Polydecene, Ethylhexylglycerin, Adenosine, Caprylyl Capryl Glucoside, Disodium Edta, Panthenol, Calcium Silicate, Lactobacillus Extracellular Vesicles, Campsis Grandiflora Flower Extract, Pueraria Lobata Root Extract, Pinus Palustris Leaf Extract, Oenothera Biennis Flower Extract, Ulmus Davidiana Root Extract, Sodium Silicate, Betaine Salicylate, Citric Acid, Gluconolactone

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

How does it fit your skin?

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Prices checked 5 Nov 2026

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Ireland.

How does it fit your skin?

Scan your face, then any product: Lovi shows how well it fits you and what fits even better.

QR code: get the Lovi app
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