VT Cosmetics PDRN Essence 100 for oily acne-prone skin
Pdrn Polydeoxyribonucleotide
Sodium Hyaluronate
Niacinamide
AdenosineHigh
- HighOily Skin Fit
- HighEffectiveness
- ExcellentSafety
A great choice for oily acne-prone skin; a few serums fit it even better.
This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers excellent skin regeneration for your oily skin due to PDRN Polydeoxyribonucleotide and Sodium Hyaluronate, which plump and enhance barrier resilience. Niacinamide further aids in seboregulation, making it highly suitable for your skin type.
- The formula provides general hydration and soothing benefits with Glycerin and Panthenol, which are beneficial for your acne-prone skin.
- The product is safe for your oily skin, as it contains no harsh ingredients and includes soothing components like Glycerin and Panthenol.
How to apply
- Could be used as part of your PM routine. Start 3 times a week and build up to daily use if your skin tolerates it well.
- Apply your serum after cleansing and toning, but before putting on your moisturizer.
- Gently press 2 to 3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on clean, dry skin to help manage your blemishes safely.
- Do a patch test before your first use and avoid the delicate eye area.
People Say
★4.8Overall rating based on 1.6k+ reviewsBased on a very large amount of data, users with dry, sensitive, and combination skin highly praise this essence for its ability to deliver a glass skin finish and deep hydration without irritation. It is widely celebrated for restoring compromised barriers and plumping fine lines. A minority of users with oily skin find the texture too heavy or tacky.
Highlights
Hydration and glow Mostly Mentioned
- “Instant glass skin”
- “deeply moisturizing”
- “plumps fine lines”
- “radiant finish”
Soothing and repair Often Mentioned
- “Calms redness”
- “heals breakouts”
- “strengthens barrier”
- “non-irritating”
Fragrance-free Sometimes Noted
- “No scent”
- “great for sensitive noses”
- “unscented”
- “no artificial fragrance”
Good texture Sometimes Noted
- “Milky consistency”
- “absorbs quickly”
- “lightweight feel”
- “layers well”
Sticky finish Sometimes Noted
- “Feels sticky”
- “tacky residue”
- “hair sticks to face”
- “takes time to dry”
Nice packaging Rarely Noted
- “Airless pump”
- “hygienic design”
- “easy to dispense”
- “cute bottle”
Caused breakouts Rarely Noted
- “Caused whiteheads”
- “clogged pores”
- “broke me out”
- “small bumps”
Expensive price Rarely Noted
- “A bit pricey”
- “expensive for size”
- “waited for sale”
- “costly”
Pump design Rarely Noted
- “Pump drips”
- “messy dispenser”
- “squirts everywhere”
- “hard to control”
Texture issues Rarely Noted
- “Too thick”
- “hard to spread”
- “heavy for oily skin”
- “feels gloopy”
Sources: lovi.care, oliveyoung.com, stylekorean.com, skinsort.com, reddit.com, yesstyle.com, and more
Questions and answers
What makes VT PDRN Essence 100 a great fit for oily acne-prone skin?
VT PDRN Essence 100 is a great fit because Pdrn Polydeoxyribonucleotide and Sodium Hyaluronate help plump the skin and strengthen your skin barrier while Niacinamide manages oil. Additionally, Glycerin and Panthenol provide soothing hydration that is very gentle for acne-prone skin.
International Journal of Molecular Sciences, 2025American Journal of Clinical Dermatology, 2002
Which ingredients make this essence a good fit for oily acne-prone skin?
PDRN Polydeoxyribonucleotide and Sodium Hyaluronate strengthen your skin barrier, while Niacinamide helps balance oil. Glycerin and Panthenol also soothe and hydrate your skin without feeling heavy.
International Journal of Molecular Sciences, 2025American Journal of Clinical Dermatology, 2002
What does PDRN do for oily acne-prone skin?
PDRN helps repair skin and calms irritation, making it a good choice for oily, acne-prone skin that needs soothing care. Because this skin type also needs ingredients that clear pores and balance oil, an effective routine should include gentle exfoliants and oil-controlling elements alongside PDRN.
Pharmaceutics, 2025International Journal of Molecular Sciences, 2026
What does Hyaluronic Acid do for oily acne-prone skin?
Hyaluronic acid helps calm oily acne-prone skin by reducing sebum production and lipid synthesis in sebaceous glands. It also supports skin barrier function and improves hydration while helping deliver treatments without causing irritation.
The Journal of Investigative Dermatology, 2017Journal of Cosmetic Dermatology, 2022
Where does this essence go in a skincare routine for oily acne-prone skin?
This treatment goes in your evening routine, after cleansing and before moisturizing, for simplicity and extra safety around sun exposure. It is safe for your oily skin and helps soothe your acne-prone skin while providing hydration and oil control.
Can I use this essence with retinol, and in what order?
You can use this essence in the same routine as retinol by applying the essence first to hydrate and calm your skin before your retinol product. This layered approach is generally well tolerated, as the essence helps soothe and support your skin barrier while you use active treatments.
Journal of Cosmetic Dermatology, 2024American Journal of Clinical Dermatology, 2002
How often should I use this essence?
You can use this treatment in your evening routine, applying it after your cleansing toner and before your moisturizer. It is unlikely to cause irritation and helps keep oily, acne-prone skin calm and hydrated.
International Journal of Molecular Sciences, 2025American Journal of Clinical Dermatology, 2002
Can this essence clog pores, cause breakouts or purging for oily acne-prone skin?
This essence is unlikely to clog pores or cause breakouts for your oily acne-prone skin, as it contains no harsh ingredients and features soothing components like panthenol and glycerin. While a few reviewers have mentioned breakouts, the formula's gentle ingredients help calm the skin and support barrier recovery without blocking pores.
American Journal of Clinical Dermatology, 2002The Journal of Dermatological Treatment, 2017
Is this essence fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
Topical application of Low-Peony PDRN enhanced barrier recovery and improved periorbital skin elasticity in human subjects.
International Journal of Molecular Sciences, 2025Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women.
Scientific Reports, 2024Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment.
American Journal of Clinical Dermatology, 2002A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability.
The Journal of Dermatological Treatment, 2017A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment.
Journal of Cosmetic Dermatology, 2025Polydeoxyribonucleotide promotes skin regeneration by increasing ERK phosphorylation, collagen accumulation, and cell proliferation and migration in fibroblasts while inhibiting ERK phosphorylation and inflammatory cytokine expression in keratinocytes.
Molecular Medicine Reports, 2023A topical mixture of polydeoxyribonucleotide, vitamin C, and niacinamide delivered via a microneedling therapy system decreased skin pigmentation and increased skin elasticity by attenuating melanogenesis and the destruction of collagen and elastin fibers in a UV-B-radiated animal model.
Molecules, 2022Plant-derived polydeoxyribonucleotide from Panax ginseng promoted skin wound healing and enhanced the skin barrier by stimulating keratinocyte and fibroblast proliferation in skin cells and an artificial skin model.
Molecules, 2023Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.
Journal of Drugs in Dermatology, 2011Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.
Clinical Oral Investigations, 2022Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.
BMC Oral Health, 2019Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months.
The Journal of Dermatology, 2008Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants.
International Journal of Molecular Sciences, 2026Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts.
International Journal of Molecular Sciences, 2021
Ingredients
Water, Pdrn Polydeoxyribonucleotide, Sodium Hyaluronate, Glycerin, Butylene Glycol, Niacinamide, Panthenol, Allantoin, Adenosine, Betaine, Phenoxyethanol, Ethylhexylglycerin, Carbomer, Triethanolamine
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
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