MEDIHEAL AGE-R for mature skin
Glutathione
Collagen
Peptides
Average
- HighNormal Skin Fit
- HighEffectiveness
- HighSafety
Works for mature skin; other serums fit it better.
This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate benefits for your wrinkles and fine lines as collagen and peptides support skin elasticity and reduce the appearance of aging. This product is highly suitable for your normal skin type due to the presence of collagen and peptides which support collagen stimulation and boosting ECM synthesis.
- Glutathione offers antioxidant benefits, contributing to overall skin health and radiance.
- The safety profile is excellent, with no risks of irritation for your normal skin due to the absence of prohibited or harsh ingredients.
How to apply
- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
People Say
★4.4Overall rating based on 12.5k+ reviewsBased on a very large amount of data, users frequently achieve a 'glass skin' appearance and improved facial contouring, with many reporting enhanced product absorption and a more radiant complexion. While effective for dullness and mild sagging, results are highly dependent on consistent daily use, which some users find difficult to maintain. The device is also noted for improving skin texture and reducing pore visibility.
Highlights
Enhanced absorption Mostly Mentioned
- “products absorb instantly”
- “skincare feels supercharged”
- “no sticky residue left”
- “serums work better”
Glass skin glow Often Mentioned
- “skin looks dewy”
- “immediate glass skin”
- “glow lasts all day”
- “makeup sits better”
Time-consuming routine Often Mentioned
- “hard to stick to”
- “adds 10 mins to routine”
- “gave up after a month”
- “too much effort daily”
Improved texture Sometimes Noted
- “bumps smoothed out”
- “pores look smaller”
- “texture is softer”
- “makeup applies smoother”
Visible lifting Sometimes Noted
- “jawline looks snatched”
- “face feels tighter”
- “reduced morning puffiness”
- “cheekbones pop more”
High price point Sometimes Noted
- “very pricey investment”
- “gel is expensive”
- “not worth the full price”
- “wait for a sale”
Unpleasant sensation Sometimes Noted
- “zaps hurt sensitive areas”
- “teeth feel weird”
- “muscle twitching is creepy”
- “prickly sensation”
Potential irritation Rarely Noted
- “caused small bumps”
- “redness after use”
- “broke me out”
- “too harsh for sensitive skin”
Sources: lovi.care, medicube.us, amazon.com, youtube.com, reddit.com, cosmopolitan.com, and more
Questions and answers
How well does Mediheal AGE-R work for mature skin?
Mediheal AGE-R works reasonably well for mature skin, offering moderate benefits for wrinkles and fine lines while keeping skin safe and calm without irritation. To fit this skin type even better, a product needs exceptionally high effectiveness against aging with potent antioxidants, deep hydration, and skin-repairing ingredients.
Clinical, Cosmetic and Investigational Dermatology, 2014Dermatology Practical & Conceptual, 2022
Which ingredients make this cream a good fit for mature skin?
Collagen and peptides make this treatment a good fit by supporting firmness and helping reduce the look of fine lines, while glutathione provides antioxidant benefits for overall skin health. To work best for mature skin, a product of this type needs high concentrations of potent antioxidants, deeply hydrating components, and skin-repairing ingredients that target wrinkles exceptionally well.
Clinical, Cosmetic and Investigational Dermatology, 2014Journal of the European Academy of Dermatology and Venereology, 2024
What does Glutathione do for mature skin?
Glutathione helps mature skin by improving moisture, smoothness, and elasticity while reducing wrinkles and age spots. It also protects skin cells from everyday oxidative stress and environmental damage with a very safe profile.
Clinical, Cosmetic and Investigational Dermatology, 2014Molecules, 2026
What does Collagen do for mature skin?
Collagen helps smooth mature skin by reducing wrinkles, improving hydration, and keeping the skin firm and plump. It is a weak fit for your skin, so a product of this type needs added hyaluronic acid, antioxidants, and peptides to properly nourish and support aging skin.
Dermatology Practical & Conceptual, 2022Current Issues in Molecular Biology, 2024
Where does it go in a skincare routine for mature skin?
This treatment goes in the evening routine after cleansing. Mature skin needs a product that uses ingredients like collagen, peptides, and antioxidants to smooth fine lines and support elasticity while keeping the skin safe from irritation.
Can I use this cream with retinol, and in what order?
You can use this treatment with retinol by applying your retinol first and following with this cream, or by alternating the nights you use each product to keep your skin calm and comfortable. This product has a very safe profile and is unlikely to cause irritation, but mature skin also needs ingredients like retinoids or intensive firming peptides to provide better anti-aging results.
Clinical, Cosmetic and Investigational Dermatology, 2014Journal of the European Academy of Dermatology and Venereology, 2024
How often should I use it?
You can use this treatment in your evening routine, applying it once a day or a few times a week as your skin adjusts. Mature skin often needs a routine that combines antioxidants like glutathione with collagen-boosting ingredients and peptides to improve firmness and smooth out fine lines.
Clinical, Cosmetic and Investigational Dermatology, 2014Journal of the European Academy of Dermatology and Venereology, 2024
Can this cream clog pores, cause breakouts or purging for mature skin?
This cream is unlikely to clog pores or cause breakouts for mature skin since it has an excellent safety profile without harsh ingredients. However, a product for this skin needs rich moisturizers and barrier-supporting ingredients to keep mature skin feeling soft and smooth.
Dermatology Practical & Conceptual, 2022Current Issues in Molecular Biology, 2024
What the research says
Both oral and topical collagen supplements help delay the skin aging process by improving moisture, elasticity, and hydration, with no differences arising between the two types of collagen.
Dermatology Practical & Conceptual, 2022The use of cosmetic products containing collagen or its peptides improves the general condition of the skin, reduces wrinkle depth, improves hydration and density, reduces transepithelial water loss, and delays the aging process, while oral bioactive collagen peptides also reduce nail breakage.
Current Issues in Molecular Biology, 2024Bioactive glycyrrhizic acid and oxymatrine ionic liquid self-assembled nanomicelles significantly promoted the transdermal permeation, subcutaneous retention, and anti-photoaging efficacy of palmitoyl pentapeptide-4 in cellular and animal models compared to unformulated peptide.
Advanced Science, 2025Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2014Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls.
Journal of the European Academy of Dermatology and Venereology, 2024Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity.
The Journal of Clinical and Aesthetic Dermatology, 2025RayGel reduced skin reaction severity with a lower average score of 93.7 compared to 123.3 for the placebo group in patients undergoing whole breast external-beam irradiation.
American Journal of Surgery, 2005Combining high-intensity focused ultrasound with a topical agent containing glutathione and hyaluronic acid significantly improves skin quality, fine wrinkles, hyperpigmentation, hydration, and brightness in female volunteers compared to the topical agent alone.
The Journal of Dermatological Treatment, 2024Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris.
Journal of Cosmetic Dermatology, 2022Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks.
International Journal of Molecular Sciences, 2022Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers.
Marine Drugs, 2023
Ingredients
Glutathione, Collagen, Peptides
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
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