MEDIHEAL AGE-R for combination skin
Glutathione
Collagen
Peptides
Low
- HighCombination Skin Fit
- AverageEffectiveness
- HighSafety
A weak match for combination skin; the serums alongside fit it better.
This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate skin firming for your combination skin due to collagen and peptides, which support elasticity and hydration without exacerbating oiliness.
- While the formula is safe and free of harsh ingredients for your combination skin, it lacks specialized ingredients to effectively target oily shine.
- The product is safe for your combination skin as it contains no prohibited or harsh ingredients, minimizing irritation risks.
How to apply
- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
People Say
★4.4Overall rating based on 12.5k+ reviewsBased on a very large amount of data, users frequently achieve a 'glass skin' appearance and improved facial contouring, with many reporting enhanced product absorption and a more radiant complexion. While effective for dullness and mild sagging, results are highly dependent on consistent daily use, which some users find difficult to maintain. The device is also noted for improving skin texture and reducing pore visibility.
Highlights
Enhanced absorption Mostly Mentioned
- “products absorb instantly”
- “skincare feels supercharged”
- “no sticky residue left”
- “serums work better”
Glass skin glow Often Mentioned
- “skin looks dewy”
- “immediate glass skin”
- “glow lasts all day”
- “makeup sits better”
Time-consuming routine Often Mentioned
- “hard to stick to”
- “adds 10 mins to routine”
- “gave up after a month”
- “too much effort daily”
Improved texture Sometimes Noted
- “bumps smoothed out”
- “pores look smaller”
- “texture is softer”
- “makeup applies smoother”
Visible lifting Sometimes Noted
- “jawline looks snatched”
- “face feels tighter”
- “reduced morning puffiness”
- “cheekbones pop more”
High price point Sometimes Noted
- “very pricey investment”
- “gel is expensive”
- “not worth the full price”
- “wait for a sale”
Unpleasant sensation Sometimes Noted
- “zaps hurt sensitive areas”
- “teeth feel weird”
- “muscle twitching is creepy”
- “prickly sensation”
Potential irritation Rarely Noted
- “caused small bumps”
- “redness after use”
- “broke me out”
- “too harsh for sensitive skin”
Sources: lovi.care, medicube.us, amazon.com, youtube.com, reddit.com, cosmopolitan.com, and more
Questions and answers
Why is Mediheal AGE-R a weak match for combination skin?
Mediheal AGE-R is a weak match for your combination skin because it lacks specialized ingredients to effectively target oily shine. A treatment of this type needs ingredients like niacinamide, propolis, or zinc PCA to balance oiliness and maintain skin health.
Dermatology Practical & Conceptual, 2022Current Issues in Molecular Biology, 2024
Which ingredients make this treatment a poor fit for combination skin?
This treatment is a weak match for your combination skin because it lacks specialized ingredients like niacinamide, zinc PCA, or propolis to effectively target and regulate oily shine. To truly fit combination skin, a product of this type needs ingredients that balance moisture and manage oiliness without causing excess shine or dryness.
Dermatology Practical & Conceptual, 2022Current Issues in Molecular Biology, 2024
What does Glutathione do for combination skin?
Glutathione helps brighten sun-exposed areas and reduce dark spots for combination skin, while also improving moisture and smoothness. It is unlikely to cause irritation and maintains a safe profile for regular use.
Clinical, Cosmetic and Investigational Dermatology, 2014International Journal of Dermatology, 2025
What does Collagen do for combination skin?
Collagen helps keep combination skin smooth and hydrated by improving moisture and supporting elasticity. It is unlikely to cause irritation and may help reduce the appearance of fine lines while keeping the skin barrier balanced.
Dermatology Practical & Conceptual, 2022Current Issues in Molecular Biology, 2024
Where does this treatment go in a skincare routine for combination skin?
This treatment goes in your evening routine, specifically after cleansing and before your moisturizer. A product of this type needs specialized ingredients like niacinamide to help manage oily shine while supporting your combination skin.
Can I use it with retinol, and in what order?
You can use this treatment with retinol, applying the treatment first and following with your retinol product. Because this product lacks oil-controlling ingredients, combination skin also needs lightweight balancing ingredients and oil-absorbing minerals to manage shine.
How often should I use this treatment?
You can use this treatment in your evening routine, applying it after your cleansing toner and before your moisturizer. It is a weak match for combination skin, so this type of product needs added oil-absorbing ingredients to help manage oily shine while keeping the skin soft and smooth.
Dermatology Practical & Conceptual, 2022Current Issues in Molecular Biology, 2024
Can it clog pores, cause breakouts or purging for combination skin?
Mediheal AGE-R is unlikely to clog pores or cause breakouts for your combination skin because it contains no harsh or heavy ingredients that typically trigger blemishes. However, since this weak match lacks specialized ingredients to control oily shine, combination skin that is prone to breakouts still needs oil-balancing ingredients like niacinamide or salicylic acid to stay clear.
What the research says
Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls.
Journal of the European Academy of Dermatology and Venereology, 2024Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2014Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity.
The Journal of Clinical and Aesthetic Dermatology, 2025Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris.
Journal of Cosmetic Dermatology, 2022Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks.
International Journal of Molecular Sciences, 2022Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers.
Marine Drugs, 2023
Why other serums fit combination skin better
Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo.
BioMed Research International, 2022A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions.
Journal of Cosmetic Dermatology, 2024
Ingredients
Glutathione, Collagen, Peptides
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
Scan your face, then any product: Lovi shows how well it fits you and what fits even better.