Medicube Triple Collagen Serum for acne-prone skin
Triple Collagen Complex
Sodium Hyaluronate
Niacinamide
AdenosineHigh
- HighCombination Skin Fit
- HighEffectiveness
- ExcellentSafety
A great choice for acne-prone skin; a few serums fit it even better.
This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Highly suitable for your combination skin, this serum leverages niacinamide to help regulate oil production and multiple forms of collagen and hyaluronic acid to provide excellent plumping and firming effects.
- While the hydration and barrier repair actions are beneficial, the primary ingredients do not directly target your concerns of acne, blemishes, and breakouts.
- The formula is safe for your skin, containing soothing ingredients like glycerin and avoiding harsh or prohibited substances.
How to apply
- Use your serum as part of your PM routine and start 3x/week before working up to daily use.
- Apply this treatment after cleansing and toner, and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the product on clean, dry skin to help manage your breakouts safely.
- Avoid the eye area and do a patch test before your first use.
People Say
★4.8Overall rating based on 200+ reviewsUsers frequently report this serum provides deep hydration, leading to a plumped, radiant complexion often described as 'glass skin'. It is well-loved for its smooth, non-greasy texture and effectiveness in diminishing fine lines, making it a great base for makeup. Some users find the fragrance to be strong and occasionally encounter issues with the packaging.
Highlights
Deep hydration Mostly Mentioned
- “Keeps skin hydrated even in depths of winter”
- “Skin feels nice and smooth”
- “Provides deep hydration.”
Glow and radiance Often Mentioned
- “Gives me glass skin”
- “Leaves a radiant glow”
- “Skin looks healthy and glowy.”
Good texture Sometimes Noted
- “Absorbs well without feeling sticky”
- “Silky texture”
- “Thick consistency but easy to apply.”
Plumping and anti-aging Sometimes Noted
- “Skin looks plumper”
- “Fine lines are diminished”
- “Improves skin elasticity.”
Packaging issues Sometimes Noted
- “Challenging to remove the cap”
- “Often taking the pump along with it”
- “Struggled to close it properly.”
Strong fragrance Sometimes Noted
- “Smells just a little bit cheap”
- “Contains fragrance”
- “Scent is a bit much.”
Makeup compatibility Rarely Noted
- “Layers beautifully under makeup”
- “Prevents makeup from looking cakey”
- “Perfect base for makeup.”
Skin sensitivity Rarely Noted
- “Caused small red bumps”
- “Feel a bit tingly”
- “Broke me out.”
Slightly sticky Rarely Noted
- “A bit sticky”
- “Can be a bit heavy”
- “Leaves a slight tack/film.”
Small quantity Rarely Noted
- “Amount is less than expected”
- “Use it up rather quickly”
- “Small bottle.”
Sources: lovi.care, iherb.com, yesstyle.com, olivekollection.com, beautybay.com, hikoco.co.nz, and more
Questions and answers
What makes Medicube Triple Collagen Serum a great fit for acne-prone skin?
This serum is a great fit because it uses niacinamide to help control oil production while delivering soothing and hydrating ingredients like glycerin and hyaluronic acid. It is very safe for your skin, though it does not directly target breakouts or blemishes.
Scientific Reports, 2024Clinical, Cosmetic and Investigational Dermatology, 2017
Which ingredients make this serum a good fit for acne-prone skin?
This serum is a good fit because it includes niacinamide to help control oil, alongside glycerin to soothe your skin. While it is safe and provides nice hydration, it lacks ingredients that directly target breakouts.
What does Triple Collagen do for acne-prone skin?
Triple Collagen helps keep acne-prone skin calm and clear by supporting overall skin health. This type of product works best when it also includes ingredients that soothe angry spots and balance oily areas without clogging pores.
What does Hyaluronic Acid do for acne-prone skin?
Hyaluronic acid helps acne-prone skin by soothing irritation, calming redness, and keeping the skin balanced without clogging pores. When combined with targeted ingredients like zinc oxide, it may also help reduce breakouts.
Where does this serum go in a skincare routine for acne-prone skin?
This treatment serum goes in the evening routine after cleansing and before moisturizing, which keeps it simple and safe. Niacinamide helps regulate oil production, while collagen and hyaluronic acid provide plumping effects.
Can I use it with retinol, and in what order?
You can use this treatment with retinol by applying the retinol first, letting it dry, and then following with this serum. This order helps keep your skin calm and hydrated while minimizing any potential irritation from the retinol.
Journal of Cosmetic Dermatology, 2024Clinical, Cosmetic and Investigational Dermatology, 2017
How often should I use this serum?
You can use this serum in your evening routine. It is a great fit for your skin, featuring niacinamide to help balance oil and hyaluronic acid for hydration.
Scientific Reports, 2024Clinical, Cosmetic and Investigational Dermatology, 2017
Can it clog pores, cause breakouts or purging for acne-prone skin?
Medicube Triple Collagen Serum is unlikely to clog pores or cause breakouts on acne-prone skin because it avoids harsh substances and includes soothing ingredients like glycerin. While it does not directly target breakouts, niacinamide helps regulate oil production to keep skin balanced.
Is it fragrance-free and alcohol-free?
It contains fragrance (linalool and limonene) and drying alcohol (alcohol denat).
What the research says
Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women.
Scientific Reports, 2024Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone.
Dermatologic Therapy, 2022A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris.
Journal of Cosmetic Dermatology, 2022Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks.
International Journal of Molecular Sciences, 2022Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers.
Marine Drugs, 2023Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.
Journal of Drugs in Dermatology, 2011Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.
Clinical Oral Investigations, 2022Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.
BMC Oral Health, 2019Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months.
The Journal of Dermatology, 2008Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants.
International Journal of Molecular Sciences, 2026Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts.
International Journal of Molecular Sciences, 2021
Ingredients
Water, Glycerin, Butylene Glycol, Cetyl Ethylhexanoate, Niacinamide, Glycereth-26, Alcohol Denat, 1,2-Hexanediol, Trehalose, Carbomer, Cetearyl Olivate, Tromethamine, Sorbitan Olivate, Ethylhexylglycerin, Collagen Extract, Adenosine, Disodium Edta, Atelocollagen, Desamido Collagen, Hydrolyzed Collagen, Sodium Hyaluronate, Water-Soluble Collagen, Sodium Hyaluronate Crosspolymer, Hydrolyzed Sodium Hyaluronate, Hydrolyzed Hyaluronic Acid, Collagen, Collagen Amino Acids, Sodium Acetylated Hyaluronate, Procollagen, Cyclopentasiloxane, Hydroxypropyltrimonium Hyaluronate, Cyclohexasiloxane, Dimethicone, Benzyl Benzoate, Linalool, Limonene
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
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