medicube Exosome Cica Calming Toner for dry skin

How to apply

Questions and answers

What the research says

• Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements.

  Indian Journal of Pharmaceutical Sciences, 2016

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components.

  Molecules, 2023

• Combined treatment with human adipose tissue stem cell-derived exosome-containing solution and microneedling significantly improved skin wrinkles, elasticity, hydration, and pigmentation compared to microneedling alone in twenty-eight individuals with facial skin aging.

  Journal of Cosmetic Dermatology, 2023

• Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing.

  Journal of Alternative and Complementary Medicine, 2020

• Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects.

  Journal of Cosmetic Dermatology, 2019

• Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline.

  Experimental Dermatology, 2008

• Adjuvant application of human adipose tissue stem cell-derived exosomes gel following fractional CO2 laser significantly improved the reduction of acne scars (32.5% vs 19.9%, p < 0.01) and reduced erythema and downtime in 25 patients compared to the control gel.

  Acta Dermato-venereologica, 2020

• Topical mesenchymal stem cell-derived exosomes reduced Ocular Surface Disease Index scores, increased tear secretion, lowered fluorescein scores, prolonged tear-film break-up time, increased Epidermal Growth Factor and thrombospondin-1, and decreased interleukin-6 and Matrix metalloproteinase-9 in patients with Sjögren's syndrome-related dry eye compared to phosphate buffered saline control.

  BMC Ophthalmology, 2025

• Topical human platelet extract exosome serum improved skin health scores and reduced redness, wrinkles, and melanin production while enhancing luminosity and color evenness at 6 weeks.

  Aesthetic Surgery Journal, 2022

• Quercetin phospholipids 1% cream significantly reduced UV-, histamine-, and chemical-induced skin erythema (-10.05%) and mean wheal diameter in 30 healthy human volunteers, showing comparable efficacy to 1% dexchlorpheniramine cream.

  Clinical, Cosmetic and Investigational Dermatology, 2016

• Quercetin-loaded niosomes formulated with Span60-RH40 at a 9:11 mass ratio improved quercetin solubility, photostability, sustained release, and transdermal penetration, yielding a skin retention 2.95 times higher than quercetin solution.

  Molecules, 2019

• Optimized rutin-loaded glycerosomes formulated into a nanosunscreen gel demonstrated sustained drug release, greater skin permeation, good antioxidant activity, and better epidermal retention compared to the dermis, indicating high safety, stability, and sun protection factor values for topical administration.

  Gels, 2023

Why other toners fit dry skin better

• Apigenin protects against UVA-induced cytotoxicity and senescence in normal human dermal fibroblasts, decreases MMP-1 expression, and when applied topically as a cream in human subjects, increases dermal density and elasticity while reducing fine wrinkle length, skin evenness, moisture content, and transepidermal water loss compared to control cream.

  International Journal of Molecular Medicine, 2016

• Lavandula angustifolia leaf callus extract enhanced skin cell viability, reduced oxidative stress and melanin content, improved wound healing, and enhanced skin barrier function in human skin cells and clinical tests.

  Free Radical Biology & Medicine, 2025

Ingredients

Centella Asiatica Extract, Exosome, Heart Leaf Extract, Extract Tree, Glycerin, Butylene Glycol, Water

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.