make p:rem UV Defense Me. Calming Sun Cream SPF 50 for skin with dark spots

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Questions and answers

What the research says

• Encapsulating Moringa oleifera Lam. isothiocyanate in flexible nanoliposomes modified with amphiphilic hyaluronic acid conjugated with ceramide improved entrapment efficiency, particle size, skin permeation, and cellular uptake while protecting HaCaT cells against UVB-induced photoaging damage.

  Drug Delivery, 2022

• Optimized transfersomes loaded with epigallocatechin-3-gallate and hyaluronic acid increased cell viability while reducing lipid peroxidation, intracellular ROS, and MMP expression in HaCaT cells, and exhibited higher skin permeation and deposition compared to plain EGCG.

  Drug Delivery, 2017

• Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements.

  Indian Journal of Pharmaceutical Sciences, 2016

• Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components.

  Molecules, 2023

• Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing.

  Journal of Alternative and Complementary Medicine, 2020

• Topical 0.5% hyaluronic-ZnO nanogel applied twice daily reduced inflammatory-lesion counts by 58% at week four in human subjects compared to baseline without causing erythema.

  Biomedicines, 2025

• Nels cream achieved a similar reduction in inflammatory and noninflammatory lesion counts compared to 5% benzoyl peroxide in acne vulgaris patients, but caused significantly fewer side-effects such as peeling and dryness.

  Clinical and Experimental Dermatology, 2000

• Topically applied coated and uncoated zinc oxide nanoparticles under flexing and massage are retained in the stratum corneum with no significant penetration into the viable epidermis and no cellular toxicity in human skin.

  Nanomedicine, 2016

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects.

  Journal of Cosmetic Dermatology, 2019

• Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline.

  Experimental Dermatology, 2008

• Aqueous standardized leaf extracts of Moringa oleifera showed the highest human dermal fibroblast and human keratinocyte proliferation and migration properties, leading to the development of an alginate-pectin film dressing with optimal physicochemical properties.

  Journal of Ethnopharmacology, 2018

• Topical administration of Moringa oleifera seed extract on excision wounds in male albino rabbits significantly increased the wound healing rate, elevated TGF-β1, VEGF, and Type I collagen relative expression, and reduced inflammatory markers like IL-1β and TNF-α compared to untreated and MEBO-treated groups.

  Antioxidants, 2022

• Moringa oleifera leaf extracts provided significant UV protection with an SPF of 2 at 2% to 4% concentrations and showed no significant irritant potential in cosmetic formulations.

  Molecules, 2018

• Pretreatment with Cardiospermum halicacabum extract ameliorated UVB-triggered cellular senescence, inhibited intracellular ROS generation, restored mitochondrial respiratory function, and suppressed the hyperactivation of the PI3K/Akt/mTOR signaling cascade in human skin fibroblasts.

  International Journal of Molecular Sciences, 2026

Ingredients

Water, Zinc Oxide, Cyclohexasiloxane, Butyloctyl Salicylate, Propanediol, Propylheptyl Caprylate, Isododecane, Polyglyceryl-3 Polydimethylsiloxyethyl Dimethicone, Caprylyl Methicone, Disiloxane, Moringa Oleifera Seed Extract, Cardiospermum Halicacabum Vine Extract Flower Leaf, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Sodium Hyaluronate, Bambusa Vulgaris Water, Ribes Nigrum Seed Oil, Helianthus Annuus Seed Oil Sunflower Seed Oil, Madecassoside, Fructan, Biosaccharide Gum-4, Pyrus Communis Fruit Extract, Prunus Persica Fruit Extract, Cucumis Melo Fruit Extract, Hedera Helix Stem Extract Leaf, Rosa Damascena Flower Water, Jasmine Flower Water, Disteardimonium Hectorite, Magnesium Sulfate, Triethoxycaprylylsilane, 1,2-Hexanediol, Polyglyceryl-2 Dipolyhydroxystearate, Polymethylsilsesquioxane, Lauryl Polyglyceryl-3 Polydimethylsiloxyethyl Dimethicone, Glyceryl Caprylate, Caprylyl Glycol, Ethylhexylglycerin, Tocopherol, Octyldodecanol, Maltodextrin, Butylene Glycol

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.