La Roche-Posay Effaclar H Iso-Biome Soothing Cleansing Cream for dry sensitive skin

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Questions and answers

What the research says

• Treatment with sodium lauryl ether sulfate emulsion increased transepidermal water loss and skin surface pH while reducing stratum corneum hydration and natural moisturizing factor content compared to diacyl phospholipid emulsions and controls, irrespective of UVA irradiation, in eight healthy volunteers.

  International Journal of Pharmaceutics, 2026

• Skin irritation potential of surfactant mixtures in 13 human subjects was dose dependent, with the highest irritation observed in formulations containing sodium laureth sulfate, lauryl glucoside, and cocamide DEA together.

  International Journal of Cosmetic Science, 1999

• Squamometry successfully detected subclinical skin surface alterations and discriminated between the irritating effects of sodium lauryl sulfate and sodium laureth sulfate on human skin using an open assay model.

  Food and Chemical Toxicology, 2001

• Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

  Journal of Cosmetic Dermatology, 2021

• Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

  The Journal of Investigative Dermatology, 2008

• Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

  Dermatologic Surgery, 2005

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.

  Journal of Cosmetic Dermatology, 2020

• Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.

  International Journal of Cosmetic Science, 2001

• A combination cream of stimu-tex AS and saccharide isomerate reduced erythema, increased skin capacitance, and reduced transepidermal water loss compared to placebo in 20 subjects after fractional CO2 laser procedure without causing serious adverse events.

  Lasers in Medical Science, 2025

• A skin barrier restoring cream with shea butter, silkflo, and vitamin E increased type I procollagen synthesis, enhanced antioxidant enzyme activity, decreased reactive oxygen species generation, and promoted hyaluronic acid production in H2O2-stimulated human keratinocyte cells compared to untreated cells.

  International Journal of Cosmetic Science, 2025

• A dermocosmetic formulation containing Vichy volcanic mineralizing water, Vitreoscilla filiformis extract, niacinamide, hyaluronic acid, and vitamin E accelerated skin renewal, improved antioxidant defenses, enhanced skin barrier recovery after acute stress, and improved microbiome recovery compared to untreated skin.

  Journal of the European Academy of Dermatology and Venereology, 2022

• The combination of Vitreoscilla filiformis extract and Vichy volcanic mineralizing water strengthens the skin barrier by stimulating skin differentiation and tight junctions, enhances biochemical defenses via antimicrobial peptides, and supports cellular immune defenses by increasing the IL-10/IL-12 ratio and protecting Langerhans cells from ultraviolet radiation compared to controls.

  Journal of the European Academy of Dermatology and Venereology, 2022

• Topical bixin application suppresses acute UV-induced photodamage and PUVA-induced hair graying in Nrf2+/+ mice compared to Nrf2-/- mice via NRF2 activation.

  Frontiers in Pharmacology, 2018

Ingredients

Water, Glycerin, Sodium Laureth Sulfate, Peg-200 Hydrogenated Glyceryl Palmate, Coco-Betaine, Polysorbate 20, Citric Acid, Peg-7 Glyceryl Cocoate, Niacinamide, Bixa Orellana Seed Extract, Butyrospermum Parkii Butter, Shea Butter, Cocamide Mea, Glycol Distearate, Sodium Chloride, Sodium Hydroxide, Mannose, Disodium Edta, Vitreoscilla Ferment, Maltodextrin, Polyquaternium-11, Acrylates Copolymer, Sodium Benzoate, Parfum

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.