Galderma Epiduo Gel for combination skin
Adapalene
Benzoyl Peroxide
Docusate Sodium
Glycerin
Simulgel 600 Pha
Average
- HighCombination Skin Fit
- HighEffectiveness
- HighSafety
Works for combination skin; other serums fit it better.
This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate treatment for your oily shine and acne-prone skin, as adapalene and benzoyl peroxide work to reduce acne lesions and blemishes. Glycerin and propylene glycol provide hydration, which is beneficial for your combination skin.
- The keratolytic action and seboregulation of adapalene and benzoyl peroxide make it highly suitable for your combination skin type.
- The product is safe for your combination skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.
How to apply
- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
People Say
★3.7Overall rating based on 1000+ reviewsUsers find this gel effective for stubborn acne, including cystic and hormonal types, with many experiencing significant skin clearing after an initial adjustment. However, the treatment is frequently associated with harsh side effects such as intense burning, dryness, and an initial worsening of acne, necessitating patience and a diligent moisturizing routine.
Highlights
Intense burning Mostly Mentioned
- “face on fire”
- “burns like crazy”
- “stings upon application”
Severe dryness Mostly Mentioned
- “skin flaking off”
- “lizard skin”
- “extremely dry patches”
Clears cystic acne Often Mentioned
- “cystic acne gone”
- “cleared hormonal breakouts”
- “stopped deep cysts”
Prevents breakouts Often Mentioned
- “stops new pimples”
- “keeps face clear”
- “preventative maintenance”
Initial acne purge Often Mentioned
- “got worse first”
- “broke out badly”
- “horrible purge phase”
Redness and irritation Often Mentioned
- “red as tomato”
- “face looks sunburned”
- “raw and irritated”
Fades scars Sometimes Noted
- “scars are fading”
- “hyperpigmentation reduced”
- “marks less visible”
Smooths skin texture Sometimes Noted
- “skin feels smooth”
- “bumps are gone”
- “texture is amazing”
Bleaches fabrics Sometimes Noted
- “bleached my towels”
- “ruined my pillowcases”
- “stained my clothes”
Sources: lovi.care, drugs.com, webmd.com, doctorfox.co.uk, and more
Questions and answers
How well does Epiduo Gel work for combination skin?
Galderma Epiduo Gel offers moderate treatment for your oily shine and acne-prone skin, as adapalene and benzoyl peroxide work to reduce blemishes. It is safe for your combination skin, with no risks of irritation, while glycerin and propylene glycol provide helpful hydration. Treatments that fit combination skin best need ingredients like niacinamide, propolis, and zinc PCA to regulate oiliness, enhance radiance, and provide hydration without excess oil or dryness.
American Journal of Clinical Dermatology, 2018American Journal of Clinical Dermatology, 2022
Which ingredients make this gel a good fit for combination skin?
Adapalene and benzoyl peroxide help reduce acne and control oil shine, while glycerin and propylene glycol provide much-needed hydration for combination skin. To work even better for this skin type, a product of this type needs effective ingredients like niacinamide and propolis that provide excellent skincare benefits, enhance radiance, and regulate oiliness without any risk of irritation or unsuitability.
American Journal of Clinical Dermatology, 2018American Journal of Clinical Dermatology, 2022
What does Adapalene do for combination skin?
Adapalene clears pores and calms inflammation to help treat breakouts in combination skin. Because it can make combination skin feel tight and dry, it works best when paired with soothing hydrators like ceramides.
Journal of Drugs in Dermatology, 2023Dermatology and Therapy, 2017
What does Benzoyl Peroxide do for combination skin?
Benzoyl peroxide helps clear acne and reduce blemishes for combination skin by targeting breakout-causing bacteria. Because it can sometimes cause dryness or tightness in sensitive areas, it is important to follow with a good moisturizer to keep the skin balanced.
The Cochrane Database of Systematic Reviews, 2020Journal of Drugs in Dermatology, 2013
Where does this gel go in a skincare routine for combination skin?
This treatment goes in the evening routine after cleansing and before moisturizing. Putting it in the evening keeps things simple and adds extra safety around sun exposure.
Can I use this gel with retinol, and in what order?
You should not use this gel in the same routine as retinol, because combining these strong ingredients greatly increases your likelihood of dryness, peeling, and irritation. Instead, a treatment of this type works best for combination skin when paired with gentle hydrators like glycerin and soothing ingredients that protect your moisture barrier.
How often should I use this gel?
Use this gel in your evening routine, applying it once a day as part of your weekly schedule. Daily application helps reduce acne blemishes and prevents atrophic scarring while keeping your skin safe from irritation.
Can this gel clog pores, cause breakouts or purging for combination skin?
Yes, this gel can cause an initial breakout or purging when you start using it, along with a high likelihood of severe dryness, redness, and intense burning. To work best for combination skin, a product of this type needs soothing and hydrating ingredients like glycerin to help balance out the strong blemish-fighting treatments.
American Journal of Clinical Dermatology, 2018American Journal of Clinical Dermatology, 2022
Is this gel fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
Daily application of adapalene 0.3%/benzoyl peroxide 2.5% gel reduced and prevented atrophic acne scar formation, achieving a total scar count change of -15.5% versus +14.4% for vehicle over 24 weeks in 67 subjects with moderate or severe facial acne.
American Journal of Clinical Dermatology, 2018Once-daily fixed-dose clindamycin phosphate 1.2%/benzoyl peroxide 3.1%/adapalene 0.15% gel achieved superior treatment success (52.5%) and greater reductions in inflammatory and noninflammatory lesions compared to vehicle (8.1%) and dyad component gels in participants with moderate-to-severe acne over 12 weeks.
American Journal of Clinical Dermatology, 2022Tea tree oil nanoemulsion containing adapalene gel demonstrated significantly greater reductions in total, inflammatory, and non-inflammatory acne lesions as well as acne severity index compared to adapalene marketed gel in 100 patients with acne vulgaris over 12 weeks.
Archives of Dermatological Research, 2022Topical benzoyl peroxide may improve acne more effectively than placebo or no treatment, while showing little to no difference compared with adapalene or clindamycin, but with an increased risk of treatment discontinuation due to adverse effects compared to placebo.
The Cochrane Database of Systematic Reviews, 2020Topical clindamycin phosphate 1.2%/adapalene 0.15%/benzoyl peroxide 3.1% gel achieved significantly greater treatment success and lesion reductions compared to vehicle in participants with moderate-to-severe acne.
Journal of the American Academy of Dermatology, 2023Treatment with adapalene 0.3%/benzoyl peroxide 2.5% gel for 48 weeks reduced atrophic acne scar counts by 26.9% in subjects with moderate or severe facial acne, while delayed treatment starting at week 24 resulted in a smaller final reduction.
American Journal of Clinical Dermatology, 2019Adapalene 0.3 %/benzoyl peroxide 2.5 % gel applied once daily for 12 weeks achieved a superior success rate of 33.7% compared to 11.0% for vehicle in subjects with moderate and severe inflammatory acne.
American Journal of Clinical Dermatology, 2016Adapalene 0.3% gel showed non-inferior efficacy and a similar safety profile compared to tretinoin 0.05% cream as a treatment for cutaneous photoaging.
European Journal of Dermatology, 2018Twice daily application of a multitargeted dermocosmetic cream provided comparable efficacy to benzoyl peroxide 5% gel in reducing inflammatory, non-inflammatory, and total lesions in 150 Caucasian subjects with mild-to-moderate acne over 56 days, while demonstrating superior skin tolerability.
Journal of Cosmetic Dermatology, 2024Clindamycin-BPO 2.5% aqueous gel applied once daily provided statistically significant greater efficacy than individual active ingredients and vehicle in reducing inflammatory and noninflammatory lesions and acne severity in 2813 patients with moderate to severe acne vulgaris.
Journal of the American Academy of Dermatology, 2008A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.
Journal of Cosmetic Dermatology, 2020Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.
International Journal of Cosmetic Science, 2001
Ingredients
Adapalene, Benzoyl Peroxide, Docusate Sodium, Disodium Edetate, Glycerin, Poloxamer, Propylene Glycol, Water
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
-
Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
-
Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
-
Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
-
Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
-
Medical Board
Cosmetic chemist, SCS, IFSCC member
-
Medical Board, Medical Advisor
Dermatology MD
-
Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
-
Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
Scan your face, then any product: Lovi shows how well it fits you and what fits even better.