Clé de Peau Beauté UV Protective Cream Broad Spectrum SPF 50+ for acne-prone skin

How to apply

Questions and answers

What the research says

• Vitamin E in O/W and W/O emulsions significantly increased stratum corneum hydration and enhanced water-binding capacity, with an optimum concentration of 5%.

  Arzneimittel-Forschung, 1998

• Concurrent treatment with 3-O-ethyl ascorbic acid and cannabigerol in UVB-irradiated human keratinocytes prevents membrane structure alterations, promotes cell survival, enhances antioxidant enzyme activity and GSH- and Trx-dependent systems, reduces lipid and protein oxidative modifications, and exerts anti-inflammatory effects.

  Free Radical Biology & Medicine, 2025

• A multi-component dissolving microneedle patch loaded with glabridin, 3-O-ethyl-L-ascorbic acid, and tranexamic acid effectively reduced chloasma and age spots while demonstrating safety in clinical evaluation, alongside significant antioxidant, anti-tyrosinase, and melanin-reduction effects in vitro and in vivo.

  Polymers, 2023

• Biomimetic hyaluronic acid-stabilized zinc oxide nanoparticles selectively inhibited C. acnes, outperformed erythromycin in preclinical acne models, and safely reduced acne lesions and redness in a clinical trial.

  Journal of Controlled Release, 2025

• Oral and topical botanical products containing ingredients like ashwagandha, saffron, l-theanine, and tocopherol reduced facial redness and pigmentation and improved sleep and certain mood parameters in healthy females with sensitive skin compared to baseline.

  Journal of Clinical Medicine, 2022

• Topical 0.5% hyaluronic-ZnO nanogel applied twice daily reduced inflammatory-lesion counts by 58% at week four in human subjects compared to baseline without causing erythema.

  Biomedicines, 2025

• Nels cream achieved a similar reduction in inflammatory and noninflammatory lesion counts compared to 5% benzoyl peroxide in acne vulgaris patients, but caused significantly fewer side-effects such as peeling and dryness.

  Clinical and Experimental Dermatology, 2000

• Topically applied coated and uncoated zinc oxide nanoparticles under flexing and massage are retained in the stratum corneum with no significant penetration into the viable epidermis and no cellular toxicity in human skin.

  Nanomedicine, 2016

• Replacing 20% of the chemical UV filter octyl methoxycinnamate with urucum oil in solid lipid nanoparticles maintained the skin protection factor without inducing toxic responses or significant skin penetration in human volunteers.

  Skin Pharmacology and Physiology, 2018

• Liposomal encapsulation of octyl methoxycinnamate increases its safety, skin affinity, and in vivo solar photoprotection factor while slowing its release and enhancing retention in the stratum corneum compared to a conventional formulation.

  International Journal of Nanomedicine, 2013

• Encapsulation of ethylhexyl methoxycinnamate and butyl methoxydibenzoylmethane in lipid microparticles significantly reduced their in vivo human skin penetration compared to nonencapsulated filters.

  Skin Pharmacology and Physiology, 2011

• Incorporating rosmarinic acid into sunscreens enhanced the in vivo SPF of octocrylene by over 157% and reduced lipid peroxidation in the human stratum corneum.

  Antioxidants, 2025

• The application of a sunscreen formulation containing ethylhexyl methoxycinnamate, ethylhexyl salicylate, methyl anthranilate, and octocrylene does not significantly affect critical acne-related species such as Cutibacterium acnes and Staphylococcus epidermidis, refuting the induction of facial dysbiosis in men.

  Archives of Dermatological Research, 2024

• Early application of sunscreen after ablative fractional skin resurfacing significantly increased the sensitization rate of the UV-filter, octocrylene, and the sunscreen compared to intact skin.

  The Journal of Dermatological Treatment, 2015

• Maximal topical applications of 6% bemotrizinol in a model sunscreen formulation did not result in meaningful systemic exposure in humans.

  Regulatory Toxicology and Pharmacology, 2023

• Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls.

  Journal of Cosmetic Dermatology, 2025

• Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate.

  Contemporary Clinical Trials Communications, 2021

• Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin.

  Journal of Cosmetic Dermatology, 2024

Ingredients

Water, Polysilicone-15, Diisopropyl Sebacate, Butylene Glycol, Glycerin, Octocrylene, Octinoxate, Zinc Oxide, Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine, Hdi Trimethylol Hexyllactone Crosspolymer, Butyl Methoxydibenzoylmethane, Dimethicone, Alcohol Denat, Behenyl Alcohol, Dipropylene Glycol, Polybutylene Glycol Ppg-9 1 Copolymer, Peg Ppg-14 7 Dimethyl Ether, Phenylbenzimidazole Sulfonic Acid, Diethylamino Hydroxybenzoyl Hexyl Benzoate, Triethanolamine, Benzophenone-3, Trehalose, Beheneth-20, Phenoxyethanol, Stearyl Alcohol, Silica, Parfum, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Tocopheryl Acetate, Carbomer, Sodium Metaphosphate, Polyquaternium-51, Limonene, Linalool, Geraniol, Benzyl Benzoate, Sodium Metabisulfite, Mica, Iron Oxides Ci 77491, Titanium Dioxide Ci 77891, Saxifraga Sarmentosa Extract, Ginkgo Biloba Leaf Extract, Thymus Serpillum Extract, Crataegus Monogyna Flower Extract, Talc, Hydrolyzed Silk, 2-O-Ethyl Ascorbic Acid, Scutellaria Baicalensis Root Extract, Uncaria Gambir Extract, Hibiscus Sabdariffa Flower Extract, Garcinia Mangostana Bark Extract, Panax Ginseng Root Extract, Bupleurum Falcatum Root Extract, Tocopherol, Theanine, Hydrolyzed Conchiolin Protein

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.