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Adapalene and vitamin C

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

Adapalene and vitamin C: keep them apart

Keep them apart

Use them at different times of day with vitamin C in the morning and adapalene at night, because combining them causes skin irritation. Vitamin C and adapalene fight when mixed and can make your skin red and flaky. You can prevent this by using a gentler strength or waiting longer between applications.

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Adapalene products

Vitamin C products

Questions and answers

Can you use adapalene and vitamin C together?

Keep adapalene and vitamin C apart because using them together increases skin irritation. Instead, alternate your routine by using vitamin C in the morning and adapalene at night.

Which goes first, adapalene or vitamin C?

Keep adapalene and vitamin C apart by using them at different times of the day, such as vitamin C in the morning and adapalene at night, to avoid increased irritation.

Are adapalene and vitamin C good for sensitive skin?

Keep adapalene and vitamin C apart in your routine because using them together may increase skin irritation and instability. Alternate their use by applying vitamin C in the morning and adapalene at night.

Research on adapalene and vitamin C

Behind this pairing advice

Lovi checks every pairing with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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