Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence
Sodium hyaluronate, Hyaluronic acid · Dermatologic Therapy, 2022Topical use of dexpanthenol in skin disorders
Vitamin b5, Panthenol · American Journal of Clinical Dermatology, 2002The Effect of Aloe Vera Clinical Trials on Prevention and Healing of Skin Wound: A Systematic Review
Aloe barbadensis leaf extract · Iranian Journal of Medical Sciences, 2019Improvement of naturally aged skin with vitamin A (retinol)
Retinol · Archives of Dermatology, 2007Final report on the safety assessment of BHT(1)
Bht · International Journal of Toxicology, 2002Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial
Ascorbic acid, Tocopherol · Journal of Cosmetic Dermatology, 2020The efficacy of 5% topical tea tree oil gel in mild to moderate acne vulgaris: a randomized, double-blind placebo-controlled study
Melaleuca alternifolia tree oil leaf · Indian Journal of Dermatology, Venereology and Leprology, 2007Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo
Retinol · International Journal of Cosmetic Science, 2017Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing
Retinol, Bakuchiol · The British Journal of Dermatology, 2019Effects of ascorbic acid on gingival melanin pigmentation in vitro and in vivo
Ascorbyl glucoside · Journal of Periodontology, 2009Apigenin inhibits UVA-induced cytotoxicity in vitro and prevents signs of skin aging in vivo
Chamomilla recutita flower extract matricaria flower extract · International Journal of Molecular Medicine, 2016Skin penetration and stabilization of formulations containing microfine titanium dioxide as physical UV filter
Titanium dioxide · International Journal of Cosmetic Science, 2000Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations
Melaleuca alternifolia tree oil leaf, Aloe barbadensis leaf extract · Clinical Pharmacology, 2018Topical benzoyl peroxide for acne
Benzoyl peroxide · The Cochrane Database of Systematic Reviews, 2020Sacha Inchi Oil (Plukenetia volubilis L.), effect on adherence of Staphylococus aureus to human skin explant and keratinocytes in vitro
Plukenetia volubilis seed oil · Journal of Ethnopharmacology, 2015Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation
Ascorbic acid, Tocopherol · Journal of Cosmetic Dermatology, 2020Comparison of clinical and histological effects between lactobacillus-fermented Chamaecyparis obtusa and tea tree oil for the treatment of acne: an eight-week double-blind randomized controlled split-face study
Melaleuca alternifolia tree oil leaf · Dermatology, 2014The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study
Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017The human stratum corneum layer: an effective barrier against dermal uptake of different forms of topically applied micronised titanium dioxide
Titanium dioxide · Skin Pharmacology and Applied Skin Physiology, 2001Benzoyl peroxide treatment decreases Cutibacterium acnes in shoulder surgery, from skin incision until wound closure
Benzoyl peroxide · Journal of Shoulder and Elbow Surgery, 2021Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy
Niacinamide · Journal of Cosmetic Dermatology, 2021Efficacy and Safety of a Fixed-Dose Clindamycin Phosphate 1.2%, Benzoyl Peroxide 3.1%, and Adapalene 0.15% Gel for Moderate-to-Severe Acne: A Randomized Phase II Study of the First Triple-Combination Drug
Benzoyl peroxide · American Journal of Clinical Dermatology, 2022Reduction in the appearance of facial hyperpigmentation by topical N-acetyl glucosamine
Acetyl glucosamine, Neoglucosamine · Journal of Cosmetic Dermatology, 2007Reduction in the appearance of facial hyperpigmentation after use of moisturizers with a combination of topical niacinamide and N-acetyl glucosamine: results of a randomized, double-blind, vehicle-controlled trial
Acetyl glucosamine, Neoglucosamine · The British Journal of Dermatology, 2010Quaternized carboxymethyl chitosan/organic montmorillonite nanocomposite as a novel cosmetic ingredient against skin aging
Bentonite · Carbohydrate Polymers, 2017A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora
Vitamin b5, Panthenol · The Journal of Dermatological Treatment, 2017Phytosphingosine enhances moisture level in human skin barrier through stimulation of the filaggrin biosynthesis and degradation leading to NMF formation
Hydration complex · Archives of Dermatological Research, 2017A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population
Salicylic acid, Microclear technology · BioMed Research International, 2020Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging
Niacinamide · Scientific Reports, 2024A topical gel of tea tree oil nanoemulsion containing adapalene versus adapalene marketed gel in patients with acne vulgaris: a randomized clinical trial
Melaleuca alternifolia tree oil leaf · Archives of Dermatological Research, 2022Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial
Allantoin · Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020High molecular compounds (polysaccharides and proanthocyanidins) from Hamamelis virginiana bark: influence on human skin keratinocyte proliferation and differentiation and influence on irritated skin
Witch hazel extract · Phytochemistry, 2001The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris: a double-blinded within-person comparative study
Glycolic acid · Clinical, Cosmetic and Investigational Dermatology, 2019A comparative study of gluconolactone versus benzoyl peroxide in the treatment of acne
Gluconolactone · The Australasian Journal of Dermatology, 1992Anti-inflammatory activity of parthenolide-depleted Feverfew (Tanacetum parthenium)
Chrysanthemum parthenium flower leaf stem juice · Inflammopharmacology, 2009Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study
Salicylic acid, Microclear technology · Journal of Cosmetic Dermatology, 2024Biomimetic hyaluronic acid-stabilized zinc oxide nanoparticles in acne treatment: A preclinical and clinical approach
Zinc oxide · Journal of Controlled Release, 2025Efficacy and Tolerability of a Skin Brightening/Anti-Aging Cosmeceutical Containing Retinol 0.5%, Niacinamide, Hexylresorcinol, and Resveratrol
Hexylresorcinol · Journal of Drugs in Dermatology, 2016Comparison of clinical efficacies of sodium ascorbyl phosphate, retinol and their combination in acne treatment
Sodium ascorbyl phosphate · International Journal of Cosmetic Science, 2009Preparation and evaluation of benzalkonium chloride hand sanitizer as a potential alternative for alcohol-based hand gels
Benzalkonium chloride · Saudi Pharmaceutical Journal, 2021Retaining Skin Barrier Function Properties of the Stratum Corneum with Components of the Natural Moisturizing Factor-A Randomized, Placebo-Controlled Double-Blind In Vivo Study
Hydration complex · Molecules, 2021Superior even skin tone and anti-ageing benefit of a combination of 4-hexylresorcinol and niacinamide
Hexylresorcinol · International Journal of Cosmetic Science, 2022Efficacy and safety of microencapsulated benzoyl peroxide and microencapsulated tretinoin for the treatment of acne vulgaris: Results from two phase 3 double-blind, randomized, vehicle-controlled studies
Benzoyl peroxide · Journal of the American Academy of Dermatology, 2023A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide
Salicylic acid, Microclear technology · Journal of Drugs in Dermatology, 2023Efficacy and tolerability of the investigational topical cream SD-101 (6% allantoin) in patients with epidermolysis bullosa: a phase 3, randomized, double-blind, vehicle-controlled trial (ESSENCE study)
Allantoin · Orphanet Journal of Rare Diseases, 2020Botulinum toxin injection as a single or combined treatment with non-cross-linked high molecular weight and low molecular weight hyaluronic acid gel for neck rejuvenation: A randomized clinical trial
Hydrolyzed hyaluronic acid · Dermatologic Therapy, 2022Subclinical, non-erythematous irritation with an open assay model (washing): sodium lauryl sulfate (SLS) versus sodium laureth sulfate (SLES)
Sodium laureth sulfate · Food and Chemical Toxicology, 2001Challenging the safety and efficacy of topically applied chlorogenic acid, apigenin, kaempferol, and naringenin by HET-CAM, HPLC-TBARS-EVSC, and laser Doppler flowmetry
Grapefruit extract · Frontiers in Chemistry, 2024Safety assessment of cyclomethicone, cyclotetrasiloxane, cyclopentasiloxane, cyclohexasiloxane, and cycloheptasiloxane
Cyclopentasiloxane · International Journal of Toxicology, 2011Is benzyl alcohol a significant contact sensitizer?
Benzyl alcohol · Journal of the European Academy of Dermatology and Venereology, 2022Evaluation of moisturizing and irritation potential of sacha inchi oil
Plukenetia volubilis seed oil · Journal of Cosmetic Dermatology, 2020Whitening effect of alpha-bisabolol in Asian women subjects
Bisabolol · International Journal of Cosmetic Science, 2010Clinical evaluation of the efficacy of a facial serum containing dioic acid, glycolic acid, salicylic acid, LHA, citric acid, and HEPES in treating post-inflammatory hyperchromia and controlling oily skin in patients with acne vulgaris
Citric acid · Journal of Cosmetic Dermatology, 2021Parthenolide-depleted Feverfew (Tanacetum parthenium) protects skin from UV irradiation and external aggression
Chrysanthemum parthenium flower leaf stem juice · Archives of Dermatological Research, 2008Assessment of Combined Ascorbyl Palmitate (AP) and Sodium Ascorbyl Phosphate (SAP) on Facial Skin Sebum Control in Female Healthy Volunteers
Sodium ascorbyl phosphate · Drug Research, 2017Solid lipid nanoparticles bearing oxybenzone: in-vitro and in-vivo evaluation
Oxybenzone, Oxybenzone-free formula · Journal of Microencapsulation, 2010Nanostructured Lipid Carrier for Topical Application of N-Acetyl Glucosamine
Acetyl glucosamine, Neoglucosamine · Advanced Pharmaceutical Bulletin, 2016Axillary hyperhidrosis. Local treatment with aluminium-chloride hexahydrate 25% in absolute ethanol with and without supplementary treatment with triethanolamine
Triethanolamine · Acta Dermato-venereologica, 1988Using ordered mesoporous silica SBA-15 to limit cutaneous penetration and transdermal permeation of organic UV filters
Oxybenzone-free formula · International Journal of Pharmaceutics, 2019Tandem repeated irritation in aged skin induces distinct barrier perturbation and cytokine profile in vivo
Toluene · The British Journal of Dermatology, 2012Enhancing Photoprotection and Mitigating Ex Vivo Stratum Corneum Oxidative Stress: A Multifunctional Strategy Combining Rosmarinic Acid with UVB Filters
Octocrylene · Antioxidants, 2025Rates of allergic sensitization and irritation to oxybenzone-containing sunscreen products: a quantitative meta-analysis of 64 exaggerated use studies
Helioplex technology, Helioplex · Photodermatology, Photoimmunology & Photomedicine, 2008Influence of vitamin E acetate on stratum corneum hydration
Tocopheryl acetate vitamin e, Tocopheryl acetate · Arzneimittel-Forschung, 1998Topical Zinc Oxide Nanoparticle Formulations for Acne Vulgaris: A Systematic Review of Pre-Clinical and Early-Phase Clinical Evidence
Zinc oxide · Biomedicines, 2025A controlled, three-part trial to investigate the barrier function and skin hydration properties of six skin protectants
Dimethicone · Ostomy/wound Management, 2005Comparative physicochemical stability and clinical anti-wrinkle efficacy of transdermal emulgel preparations of 5% sodium ascorbyl phosphate and or ascorbic acid on human volunteers
Sodium ascorbyl phosphate · Journal of Cosmetic Dermatology, 2021TiO2-embedded mesoporous silica with lower porosity is beneficial to adsorb the pollutants and retard UV filter absorption: A possible application for outdoor skin protection
Avobenzone · European Journal of Pharmaceutical Sciences, 2023A new formula for a mild body cleanser: sodium laureth sulphate supplemented with sodium laureth carboxylate and lauryl glucoside
Lauryl glucoside · International Journal of Cosmetic Science, 2014Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study
Vitamin b5, Panthenol · Journal of Cosmetic Dermatology, 2025Safety of a preservative system containing 1,2-hexanediol and caprylyl glycol
Caprylyl glycol · Cutaneous and Ocular Toxicology, 2009Cucumber (Cucumis sativus L.) with heterologous poly-γ-glutamic acid has skin moisturizing, whitening and anti-wrinkle effects
Cucumis sativus fruit extract · International Journal of Biological Macromolecules, 2024Efficacy and Tolerability of Stable Hybrid Cooperative Complexes of High- and Low-Molecular Weight Hyaluronic Acid in Asian Patients: An Open-Label Study
Hydrolyzed hyaluronic acid · Aesthetic Plastic Surgery, 2026Prospective, randomized, double-blind clinical study of split-body comparison of topical hydroquinone and hexylresorcinol for skin pigment appearance
Hexylresorcinol · Archives of Dermatological Research, 2023Instrumental, clinical and subjective evaluation of the efficacy of a cosmetic treatment for home use
Acetyl glucosamine, Neoglucosamine · Journal of Cosmetic and Laser Therapy, 2019The tandem repeated irritation test: a new method to assess prevention of irritant combination damage to the skin
Toluene · Acta Dermato-venereologica, 2002Nanocomplex of quaternized cyclodextrin grafted chitosan and hyaluronic acid for a skin delivery
Hydrolyzed hyaluronic acid · Colloids and Surfaces. B, Biointerfaces, 2022Functional properties and skin care effects of sodium trehalose sulfate
Trehalose · Skin Research and Technology, 2024A Double-Blind, 12-Week Study to Evaluate the Antiaging Efficacy of a Cream Containing the NFκB Inhibitor 4-Hexyl-1, 3-Phenylenediol and Ascorbic Acid-2 Glucoside in Adult Females
Ascorbyl glucoside · Journal of Drugs in Dermatology, 2016Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy
Tocopheryl acetate · Scientific Reports, 2025Evaulation of irritation potential of surfactant mixtures
Sodium laureth sulfate · International Journal of Cosmetic Science, 1999Comparison of clindamycin 1% and benzoyl peroxide 5% gel to a novel composition containing salicylic acid, capryloyl salicylic acid, HEPES, glycolic acid, citric acid, and dioic acid in the treatment of acne vulgaris
Citric acid · Journal of Drugs in Dermatology, 2013Facial disbiosis and UV filters
Octocrylene · Archives of Dermatological Research, 2024A Randomized Controlled Trial of the Genistein Plus Bakuchiol and Vitamins (GEN+) Product for Male Facial Skin: Effects on Skin Appearance and Properties
Bakuchiol · Skin Research and Technology, 2026Treatment with Ascorbyl Glucoside-Arginine Complex Ameliorates Solar Lentigos
Ascorbyl glucoside · International Journal of Molecular Sciences, 2024Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial
Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021Portulaca oleracea extract relieves skin barrier damage induced by increased photosensitivity after GA peeling
Portulaca oleracea extract · Cutaneous and Ocular Toxicology, 2022Retrospective Review of Dermal Safety Studies of Organic Sunscreens
Homosalate, Octisalate, Ethylhexyl salicylate · Journal of Drugs in Dermatology, 2025Acetyl Dipeptide-31 Amide: A Novel Cosmetic Anti-Inflammatory Peptide That Demonstrates Anti-Aging, Firming, and Lifting Benefits
Acetyl dipeptide-31 amide · Journal of Drugs in Dermatology, 2025Natural Moisturizing Factor-Enriched Formulations Compared to a Ceramide-Based Cream
Hydration complex · Journal of Drugs in Dermatology, 2024Synergistic combination: Developing a natural carrier-free assembled gel through hydrogen bond reconstruction strategy for efficient skin photo-damage restoration
Sodium pca · Biomaterials Advances, 2026Clinical Efficacy of Topical Ascorbic Acid 2-Glucoside in Enhancing Outcomes of Laser Gingival Depigmentation: A Randomized Controlled Trial
Ascorbyl glucoside · Cureus, 2026Efficacy and safety of combination cream of stimu-tex AS™ (spent grain wax, Argania Spinosa Kernel oil, Butyrospermum Parkii (shea butter) extract), and saccharide isomerate after fractional CO2 laser procedure: split-face, double blinded, randomized controlled trial
Butyrospermum parkii butter shea butter · Lasers in Medical Science, 2025The Therapeutic Effects of a Bentonite-Based Facial Mask With Alcea sulphurea Extract on Acne Severity and Patient Experience: Add-On Randomized Controlled Clinical Trial
Bentonite · Journal of Cosmetic Dermatology, 2025Impact of dermal emulsions containing diacyl phospholipids, mono acyl phospholipids, sodium lauryl ether sulfate and polysorbate 80 in combination with UVA irradiation on human skin physiology in vivo: A pilot study
Sodium laureth sulfate · International Journal of Pharmaceutics, 2026Split-face evaluation: Gluconolactone plus oxybrasion versus gluconolactone plus microneedling. The effects on skin parameters
Gluconolactone · Skin Research and Technology, 2023Low-temperature extracted Portulaca oleracea L. as a functional ingredient in facial masks for photorejuvenation of sensitive skin
Portulaca oleracea extract · Cutaneous and Ocular Toxicology, 2025Protection from combination exposure
Toluene · Current Problems in Dermatology, 2007
