Skin Better Science Alto Advanced Defense and Repair Serum for skin with dark spots

How to apply

Questions and answers

What the research says

• A triple combination of ergothioneine, collagen peptides, and sodium hyaluronate attenuated UV-induced skin damage ex vivo and improved facial skin hydration, elasticity, barrier function, and wrinkles in Chinese women.

  Frontiers in Nutrition, 2026

• Topical application of photolyase-containing liposomes followed by photoreactivating light decreased UVB-induced dimers by 40-45% and prevented immunosuppression, erythema, and sunburn-cell formation in healthy human subjects.

  Proceedings of the National Academy of Sciences of the United States of America, 2000

• Ergothioneine at nanomolar concentrations ameliorated UVA-induced skin damage, reactive oxygen species, and apoptosis in human keratinocyte-derived HaCaT cells by upregulating Nrf2/ARE-mediated antioxidant genes.

  Free Radical Biology & Medicine, 2015

• Topical formulations containing ascorbyl tetraisopalmitate, coenzyme Q10, green tea polyphenols, and resveratrol reduced the release of inflammatory cytokines and attenuated inflammatory signs compared to untreated skin and vehicle in 25 Japanese volunteers exposed to sodium dodecyl sulfate.

  European Journal of Pharmaceutics and Biopharmaceutics, 2017

• Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

  Journal of Cosmetic Dermatology, 2021

• Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

  The Journal of Investigative Dermatology, 2008

• Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

  Dermatologic Surgery, 2005

• Topical application of TAT-SOD significantly suppresses UVB-induced erythema formation, blood flow rise, and apoptotic sunburn cell formation in human volunteers compared to a vehicle control.

  European Journal of Pharmaceutics and Biopharmaceutics, 2016

• Topical treatment with the synthetic SOD/catalase mimetic EUK-134 reduced lipid peroxide levels both at baseline on non-irradiated human skin and at the surface of UVA-exposed skin when applied before or after irradiation, compared to controls.

  International Journal of Cosmetic Science, 2004

• Topical superoxide dismutase formulations maintained physical stability and enzymatic activity for 6 months at 4 and 30 degrees C, and effectively inhibited UVB-induced skin erythema for 48 hours, whereas formulations combined with alpha-tocopherol were unstable.

  European Journal of Pharmaceutics and Biopharmaceutics, 2007

• Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers.

  Experimental Dermatology, 2003

• Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation.

  Journal of Periodontology, 2009

• Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream.

  Journal of Cosmetic Dermatology, 2022

• A night cream containing melatonin, carnosine, and Helichrysum italicum extract reduced oxidative stress ex vivo and improved hydration, reduced transepidermal water loss, decreased wrinkles and spots, and lowered skin reactivity in 117 individuals over up to 12 weeks of nightly use.

  Dermatology and Therapy, 2020

• Supramolecular carnosine improves skin reactivity, upregulates Nrf2 expression, activates antioxidant defenses, and reduces AGE levels while demonstrating whitening efficacy in cells and clinical tests compared to conventional carnosine.

  Advanced Healthcare Materials, 2024

• A targeted skincare regimen containing active ingredients such as rhodophyceae extract, ergothioneine, and L-carnosine significantly reduced transepidermal water loss by 24.09%, improved skin elasticity, and decreased redness, dryness, and desquamation in thirty-five female Chinese participants over 4 weeks following advanced optimal pulse technology treatment.

  International Journal of Cosmetic Science, 2025

Ingredients

Acacia Decurrens Wax Flower, Acacia Senegal Gum, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Water, Arabidopsis Thaliana Extract, Arginine, Benzylidene Dimethoxydimethylindanone, Bisabolol, Buddleja Officinalis Flower Extract, Butylene Glycol, Camellia Sinensis Leaf Extract, Carbomer, Carnosine, Ceramide Ap, Ceramide Eop, Ceramide Np, Cetearyl Alcohol, Ceteth-20 Phosphate, Chlorogenic Acids, Cholesterol, Citric Acid, Coffea Arabica Extract Cell Leaf Coffee Extract Cell Leaf, Crocus Sativus Extract Cell Leaf Culture, Curcuma Longa Root Extract, Dextran, Dicetyl Phosphate, Diisostearyl Malate, Dimethyl Isosorbide, Ergothioneine, Ethylhexyl Olivate, Ethylhexylglycerin, Euterpe Oleracea Fruit Extract, Glycerin, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Helianthus Annuus Wax Seed Sunflower Wax Seed, Hydrolyzed Sodium Hyaluronate, Jojoba Esters, Lauryl Lactate, Lecithin, Linoleic Acid, Linolenic Acid, Methyl Gluceth-20, Micrococcus Lysate, Niacinamide, Olea Europaea Fruit Extract Olive Fruit Extract, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Pentylene Glycol, Phenoxyethanol, Phytosphingosine, Plankton Extract, Polyglycerin-3, Propanediol, Propanediol Dicaprylate Caprate, Pyrroloquinoline Quinone Allyl Ester, Ricinoleth-40, Sea Whip Extract, Sodium Hydroxide, Sodium Lauroyl Lactylate, Sodium Pca, Sodium Phytate, Steareth-2, Superoxide Dismutase, Tetrahexyldecyl Ascorbate, Theobroma Cacao Seed Extract, Tocopherol, Tocopheryl Acetate, Trifluoroacetyl Tripeptide-2, Ubiquinone, Vitis Vinifera Seed Extract Grape Seed Extract, Xanthan Gum, Zingiber Officinale Root Extract

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.