Medik8 Oxy-R Peptides for acne-prone skin

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Questions and answers

What the research says

• Application of a new brightening complex cream containing niacinamide, tranexamic acid, oxyresveratrol, glutathione disulfide, and linoleic acid for 12 weeks increased skin lightness (L*-value) and significantly decreased melanin index and erythema index in Korean women.

  Journal of Cosmetic Dermatology, 2017

• Topical application of mulberroside A, oxyresveratrol, and oxyresveratrol-3-O-glucoside reduced UVB-induced skin pigmentation and melanogenic enzyme expression in brown guinea pigs compared to vehicle control, with oxyresveratrol showing the greatest effect.

  Food and Chemical Toxicology, 2011

• Gluconolactone 14% solution significantly improved mild to moderate acne by reducing inflamed and non-inflamed lesions similarly to 5% benzoyl peroxide, but with fewer side-effects in 150 patients.

  The Australasian Journal of Dermatology, 1992

• Combining 10% gluconolactone chemical peeling with oxybrasion or microneedle mesotherapy increased skin hydration and decreased sebum, pH, and TEWL in twenty-one Caucasian women, with no significant differences between the two methods.

  Skin Research and Technology, 2023

• Glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene showed no hindrance compared to adapalene monotherapy and provided benefits in reducing complications in 25 subjects with mild-to-moderate acne vulgaris.

  Clinical, Cosmetic and Investigational Dermatology, 2019

• Topical oxyresveratrol microemulsion at 20-30% w/w effectively delayed skin lesion development and protected mice from death compared to untreated controls.

  AAPS PharmSciTech, 2012

• Encapsulating dihydrooxyresveratrol and oxyresveratrol into nanostructured lipid carriers enhanced photostability, promoted controlled release, facilitated skin penetration, exhibited no cytotoxicity up to 500 µg/mL on human keratinocytes, and effectively reduced melanogenesis in B16F10 cells.

  Scientific Reports, 2024

• Oxyresveratrol alleviates ultraviolet B-induced cytotoxicity and inflammation in keratinocytes by exhibiting antioxidant activity, inhibiting p38 MAPK and AP-1, and decreasing the Bax/Bcl-2 ratio.

  Heliyon, 2024

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• Application of a cream containing lactic acid 12% and pramoxine HCl 1% significantly improved skin dryness, hydration, and itch compared with a nontreated control in 24 women with a history of dry itchy skin.

  Cutis, 2004

• Topical 12% ammonium lactate produced a significant sparing of epidermal and dermal atrophy induced by clobetasol propionate in human volunteers, without influencing the corticosteroid's bioavailability or antiinflammatory properties.

  Journal of the American Academy of Dermatology, 1992

• A lactic acid/ceramide lotion significantly improved skin moisturization and desquamation compared to no treatment in women with dry, rough skin on the anterior shins.

  The Journal of Clinical and Aesthetic Dermatology, 2020

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.

  Journal of Cosmetic Dermatology, 2020

• Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.

  International Journal of Cosmetic Science, 2001

Ingredients

Water, Butylene Glycol, Artocarpus Lakoocha Extract Wood, Hydroxyresveratrol, Gluconolactone, Acetyl Glycyl Beta-Alanine, Glycerin, Lactic Acid, Sodium Hyaluronate, Sodium Benzoate, Disodium Edta, Tetrapeptide-30, Xanthan Gum, Sodium Metabisulfite, Calcium Gluconate

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.