medicube Red Calming Clay Mask for acne-prone skin

How to apply

Questions and answers

What the research says

• A bentonite-based facial mask with Alcea sulphurea extract combined with oral azithromycin significantly reduced total lesion count and acne severity index while enhancing patient satisfaction in patients with moderate acne compared to placebo plus azithromycin over 8 weeks.

  Journal of Cosmetic Dermatology, 2025

• Treatment with 45% mandelic acid peel showed nearly equal overall efficacy as 30% salicylic acid peel in patients with mild-to-moderate facial acne vulgaris, but with fewer adverse effects.

  Journal of Cosmetic Dermatology, 2020

• Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements.

  Indian Journal of Pharmaceutical Sciences, 2016

• Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components.

  Molecules, 2023

• Topical application of uncoated or silane-coated zinc oxide nanoparticles under occlusive conditions and on barrier-impaired skin of human volunteers results in no measurable penetration into or local toxicity in the viable epidermis.

  European Journal of Pharmaceutics and Biopharmaceutics, 2016

• Vectorization of high molecular weight hyaluronic acid with clay enabled its penetration into deeper skin layers and led to a significant clinical reduction in fine lines in the crow's feet area compared to placebo after 28 days.

  Skin Research and Technology, 2024

• Twice-weekly use of a clay mask over 4 weeks in 75 adults with oily or combination skin improved acne-related outcomes, sebum content, skin evenness, hydration, and reduced dryness and irritation.

  Skin Research and Technology, 2023

• Clay jojoba oil facial masks reduced total skin lesions by a mean of 54% after 6 weeks in 133 participants with acne-prone, lesioned skin and mild acne compared to baseline.

  Forschende Komplementarmedizin, 2012

• Topical 0.5% hyaluronic-ZnO nanogel applied twice daily reduced inflammatory-lesion counts by 58% at week four in human subjects compared to baseline without causing erythema.

  Biomedicines, 2025

• Topical zinc oxide 20% ointment achieved a complete cure in 50% of patients with warts compared to 42% in the salicylic acid-lactic acid group, with no serious side-effects.

  International Journal of Dermatology, 2007

• Chemical peels using 35% glycolic acid, 20% salicylic-10% mandelic acid, and phytic acid reduce acne scores by 70.55%, 74.14%, and 69.7% respectively, and significantly decline the postacne hyperpigmentation index in Asian patients with mild to moderate acne.

  Journal of Cutaneous and Aesthetic Surgery, 2019

• Commonly used chemical peels showed no significant differences in effectiveness for acne vulgaris in most comparisons, though combined salicylic and mandelic acid peeling was superior to glycolic acid and glycolic acid was superior to placebo, based on twelve randomized controlled trials.

  BMJ Open, 2018

• Treatment with 30% lactic acid peel showed a significantly greater reduction in pigmentation and higher patient satisfaction compared to 30% mandelic acid peel in patients with periorbital melanosis.

  Indian Dermatology Online Journal, 2025

• Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing.

  Journal of Alternative and Complementary Medicine, 2020

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects.

  Journal of Cosmetic Dermatology, 2019

• Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

  Journal of Cosmetic Dermatology, 2021

• Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

  The Journal of Investigative Dermatology, 2008

• Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

  Dermatologic Surgery, 2005

Why other cleansing masks fit acne-prone skin better

• Chemical peels with 30% supramolecular salicylic acid effectively treated acne and reduced facial sebum secretion while improving skin hydration and barrier function in 25 patients.

  Journal of Cosmetic Dermatology, 2022

• A 30% supramolecular salicylic acid peel improved the global acne grading score and skin barrier indicators, decreased cutaneous microbiome richness and evenness along with Staphylococcus proportion, reduced inflammatory cytokines, and increased caveolin-1 expression in 28 patients with moderate-to-severe acne vulgaris.

  Dermatology and Therapy, 2023

• A moisturizer containing licochalcone A, 1,2-decanediol, L-carnitine, and salicylic acid significantly reduced noninflammatory, inflammatory, and total acne lesion counts compared to a vehicle control in Thai patients during a 12-week maintenance phase.

  BioMed Research International, 2020

Ingredients

Water, Kaolin, Glycerin, Calamine, Propanediol, Bentonite, Caprylic Capric Triglyceride, Zea Mays Starch, Saccharide Hydrolysate, Glyceryl Stearate, 1,2-Hexanediol, Xanthan Gum, Mandelic Acid, Dimethyl Sulfone, Betaine, Butylene Glycol, Polyhydroxystearic Acid, Stearic Acid, Ethylhexylglycerin, Portulaca Oleracea Extract, Disodium Edta, Panthenol, Indigofera Tinctoria Extract, Centella Asiatica Extract, Hemerocallis Fulva Flower Extract, Hydrogenated Lecithin, Myosotis Sylvatica Stem Extract Flower Leaf, Polyglyceryl-10 Stearate, Sodium Hyaluronate, Sodium Ascorbyl Phosphate, Sodium Hyaluronate Crosspolymer, Niacinamide, Hydrolyzed Sodium Hyaluronate, Hydrolyzed Hyaluronic Acid, Sodium Acetylated Hyaluronate, Pyridoxine, Hydroxypropyltrimonium Hyaluronate, Folic Acid, Biotin, Tocopherol, Cyanocobalamin, Thiamine Hcl, Riboflavin, Linoleic Acid, Beta-Carotene

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.