Medicube PDRN Pink Peptide Serum for dry sensitive skin
Niacinamide
Hydrolyzed Collagen
Sodium DnaAverage
- HighDry Skin Fit
- HighEffectiveness
- HighSafety
Works for dry sensitive skin; other moisturizers fit it better.
- Clinical, Cosmetic and Investigational Dermatology, 2017
- International Journal of Cosmetic Science, 2013
This fit is calculated for the concerns frequently associated with dry sensitive skin: flakiness, tightness, redness, fine lines, and wrinkles. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- This serum offers moderate benefits for your dry and sensitive skin, as hyaluronic acid and glycerin provide essential hydration, while hydrolyzed collagen and atelocollagen support barrier repair. Salmon egg extract and sodium DNA contribute to skin plumping and overall revitalization.
- Niacinamide and copper tripeptide-1 further enhance skin health by addressing texture and promoting a smoother complexion.
- The product is safe for your skin, with no harsh ingredients that could cause irritation.
How to apply
- Could be used as part of your AM or PM routine. Start using this moisturizer 3 times a week and move to daily use if your dry skin tolerates it well.
- Apply this moisturizer after cleansing and toner in the morning, or after your serum in the evening. Always pair it with SPF in the morning.
- Gently press a small amount of the moisturizer into your skin. Avoid rubbing it harshly to protect your sensitive skin.
- Apply the moisturizer on slightly damp skin to help with hydration absorption. This also works well for dry and flaky skin types.
- Do a patch test before your first use. Avoid the eye area to prevent any irritation.
People Say
★4.7Overall rating based on 2.1k+ reviewsBased on a very large amount of data, this serum is highly praised for delivering intense hydration and a radiant "glass skin" glow, with users frequently reporting immediate improvements in skin plumpness and elasticity. The viscous texture is often noted for its barrier-repairing qualities. A polarizing feature is the distinct scent, described as floral and fishy, which some users find unpleasant.
Highlights
Deep hydration Mostly Mentioned
- “skin feels bouncier and hydrated”
- “keeps it plump for hours”
- “wake up with soft, plump skin”
- “deeply moisturized underneath”
Radiant glow Often Mentioned
- “healthy, dewy glow”
- “creates a natural inner glow”
- “skin looks radiant”
- “glass skin effect”
Smoother texture Often Mentioned
- “skin feels smoother”
- “refined skin texture”
- “fine lines look softer”
- “makeup applies better”
Soothing and gentle Sometimes Noted
- “no tingling or burning”
- “calmed redness”
- “zero irritation on sensitive skin”
- “feels gentle and soothing”
Unpleasant scent Sometimes Noted
- “slightly fishy smell”
- “strong floral fragrance”
- “scent is underwhelming”
- “can't get past the smell”
Caused breakouts Rarely Noted
- “small pimple appeared”
- “broke me out”
- “caused acne”
- “bumps on cheek”
Small quantity Rarely Noted
- “runs out pretty quickly”
- “wish they offered a larger version”
- “small bottle for the price”
Sticky finish Rarely Noted
- “slight sticky feeling”
- “heavy finish”
- “tacky residue”
- “feels a bit sticky”
Sources: lovi.care, oliveyoung.com, iherb.com, ulta.com, medicube.us, youtube.com, and more
Questions and answers
How well does medicube PDRN Pink Peptide Serum work for dry sensitive skin?
This serum works moderately well for dry sensitive skin, as hyaluronic acid and glycerin help provide hydration while collagen supports the skin barrier. To fit this skin type best, a moisturizing treatment needs a rich blend of deep hydrators and soothing ingredients that lock in moisture and calm dryness without irritation.
Which ingredients make this serum a good fit for dry sensitive skin?
This serum works for dry skin because hyaluronic acid and glycerin quench dryness, while hydrolyzed collagen and sodium DNA help repair and plump the skin. A moisturizing treatment for this skin type needs a rich blend of deep hydrators and soothing extracts to deliver lasting moisture and relieve flakiness without irritation.
What does Niacinamide do for dry sensitive skin?
Niacinamide helps dry sensitive skin by calming irritation and keeping moisture locked in so your face feels soft and smooth. It works to build up your skin barrier and calm redness while being very gentle and unlikely to cause irritation.
Journal of Cosmetic Dermatology, 2004International Journal of Pharmaceutics, 2013
What does Hydrolyzed Collagen do for dry sensitive skin?
Hydrolyzed collagen helps make dry skin feel much more smooth and hydrated while helping to calm sensitive areas. Regular use over a few weeks significantly improves moisture levels and helps keep the skin barrier strong and comfortable.
Where does this serum go in a skincare routine for dry sensitive skin?
This serum goes in the evening routine after your toner and before your moisturizer. Dry and sensitive skin needs a product of this type to include extra soothing ingredients and rich hydrators to calm irritation and deeply nourish dry areas.
Can I use this serum with retinol, and in what order?
You can use this serum with retinol by applying the serum first to give your skin hydration, and following with retinol once it absorbs. This type of skin benefits from adding a rich moisturizer afterwards to lock in hydration and protect the skin barrier.
How often should I use this serum?
This serum works well in your evening routine, where you can apply it daily after cleansing and toning. It is safe for your skin with no harsh ingredients that could cause irritation, but to get the best fit for dry sensitive skin, a product of this type needs rich moisturizing ingredients like ceramides, squalane, or shea butter to deeply comfort and protect dry areas.
Can this serum clog pores, cause breakouts or purging for dry sensitive skin?
Breakouts from this serum are unlikely for dry sensitive skin, as it contains no harsh ingredients that typically cause irritation. However, because this is an average fit, dry skin of this type needs a product packed with richer oils and heavy hydrators to truly stay soft and smooth.
Can I use this serum around the eyes or on my body?
Yes, you can use this moisturizing treatment around your eyes and on your body because its safety profile is very good and it is unlikely to cause irritation. To properly care for dry and sensitive skin in delicate areas like the eyelids, a product of this type needs rich hydrating ingredients like hyaluronic acid and glycerin alongside soothing barrier-repair agents to keep the skin soft and comfortable.
Surgical and Radiologic Anatomy, 2002Clinical, Cosmetic and Investigational Dermatology, 2017
Is this serum fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Treatment with salmon egg extract at concentrations of 1% and 5% significantly improved wrinkles, pigmentation, redness, brightness, and hydration in 66 healthy female volunteers in a dose- and time-dependent manner compared to baseline.
International Journal of Cosmetic Science, 2013Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer.
The British Journal of Dermatology, 2002Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris.
Journal of Cosmetic Dermatology, 2022Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks.
International Journal of Molecular Sciences, 2022Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers.
Marine Drugs, 2023Topical application of Low-Peony PDRN enhanced barrier recovery and improved periorbital skin elasticity in human subjects.
International Journal of Molecular Sciences, 2025Polydeoxyribonucleotide promotes skin regeneration by increasing ERK phosphorylation, collagen accumulation, and cell proliferation and migration in fibroblasts while inhibiting ERK phosphorylation and inflammatory cytokine expression in keratinocytes.
Molecular Medicine Reports, 2023A topical mixture of polydeoxyribonucleotide, vitamin C, and niacinamide delivered via a microneedling therapy system decreased skin pigmentation and increased skin elasticity by attenuating melanogenesis and the destruction of collagen and elastin fibers in a UV-B-radiated animal model.
Molecules, 2022
Ingredients
Water, Disodium Edta, Niacinamide, Hydrolyzed Collagen, Sodium Dna, Milt Extract, Copper Tripeptide-1, Acetyl Hexapeptide-8, Palmitoyl Pentapeptide-4, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Butylene Glycol, 1,2-Hexanediol, Glycerin, Dipropylene Glycol, Polyglycerin-3, Glyceryl Acrylate Acrylic Acid Copolymer, Pvm Ma Copolymer, Hyaluronic Acid, Ethylhexylglycerin, Glycereth-26, Adenosine, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Isopropyl Myristate, Ubiquinone, Caprylyl Glycol, Tromethamine, Sodium Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Polyisobutene, Caprylyl Capryl Glucoside, Sorbitan Oleate, Atelocollagen, Salmon Egg Extract
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
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