🇪🇸Spain

Medicube One Day Exosome Shot 2000 for oily acne-prone skin

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes

Medicube One Day Exosome Shot 2000

High

  • SuperiorOily Skin Fit
  • HighEffectiveness
  • HighSafety

A great choice for oily acne-prone skin; a few serums fit it even better.

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.

Page built Nov 8, 2026How the Fit score works

Lovi Assistant explains

  • Offers excellent suitability for your oily skin due to niacinamide and betaine salicylate, which help regulate sebum and provide mild exfoliation for improved texture and pH.
  • Lactobacillus Extracellular Vesicles and Betaine Salicylate promote skin regeneration and chemical exfoliation, offering moderate benefits for your acne, blemishes, and breakouts.
  • The formulation is safe for your oily skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

How to apply

  • Could be used as part of your PM routine. Start 3 times a week and build up to daily use if your skin tolerates it well.
  • Apply your serum after cleansing and toning, but before putting on your moisturizer.
  • Gently press 2 to 3 drops of the serum into your skin and let it absorb for a minute.
  • Apply the serum on clean, dry skin to help manage your blemishes safely.
  • Do a patch test before your first use and avoid the delicate eye area.

People Say

★4.7Overall rating based on 200+ reviews

This ampoule is highly praised for its ability to refine skin texture and minimize pores, leading to smoother skin and a glow. While a tingling sensation from spicules is frequently noted and can be uncomfortable for some, most users experience visible improvements in smoothness and reduced blackheads within weeks. Some users with sensitive skin may experience irritation or dryness.

Highlights

  • Smoother skin texture Mostly Mentioned
    • “Skin is visibly smoother and refined”
    • “Bumpy texture is finally smooth”
    • “Leaves skin feeling silky soft”
  • Prickly/tingling sensation Mostly Mentioned
    • “Feels like rubbing little needles into skin”
    • “Sensation is not exactly pleasant”
    • “Tingling was too painful for me”
  • Pore tightening Often Mentioned
    • “Pores on my nose and chin are the smallest they've ever been”
    • “Tightens open and saggy pores”
    • “Visible refinement in my pores after a week”
  • Blackhead reduction Sometimes Noted
    • “Black dots on my nose all but disappeared”
    • “Reduced my whiteheads significantly”
    • “Great for clearing clogged pores”
  • Fast results Sometimes Noted
    • “Noticed a difference the very first week”
    • “Quick texture fix”
    • “Skin looked brighter after first use”
  • Can be drying Rarely Noted
    • “Can cause dryness near lips”
    • “Needs a nourishing moisturizer after”
    • “Felt a bit stripping on dry areas”
  • Skin irritation/breakouts Rarely Noted
    • “Broke me out after 3 days”
    • “Caused redness and increased sensitivity”
    • “Irritation made it less enjoyable”

Sources: lovi.care, stylekorean.com, medicube.us, iherb.com, amazon.com, skinsort.com, and more

Questions and answers

What makes Medicube Exosome Shot 2000 a great fit for oily acne-prone skin?

Medicube One Day Exosome Shot 2000 is a great fit because it contains niacinamide and betaine salicylate, which help regulate excess oil and gently exfoliate to improve your skin's texture. It also features Lactobacillus extracellular vesicles to promote skin regeneration, offering moderate benefits for breakouts while remaining safe and gentle on your skin.

Which ingredients make this treatment a good fit for oily acne-prone skin?

Niacinamide and betaine salicylate make this treatment a great fit because they help control oil and gently smooth out texture. Lactobacillus extracellular vesicles and betaine salicylate also support skin renewal to help clear breakouts with a very low risk of irritation.

What do Lactobacillus Extracellular Vesicles do for oily acne-prone skin?

Lactobacillus extracellular vesicles help calm irritated skin and support the natural skin barrier, which is beneficial for oily acne-prone skin. These ingredients may help reduce redness and soothe breakouts while keeping the skin balanced. A product for oily acne-prone skin needs soothing ingredients and lightweight hydrators to calm flare-ups without feeling heavy.

World Journal of Microbiology & Biotechnology, 2026Frontiers in Immunology, 2026

What does Niacinamide do for oily acne-prone skin?

Niacinamide helps balance oil production, calms redness, and is unlikely to irritate oily, acne-prone skin while improving blemishes. Clinical tests show it reduces excess oil and helps clear up both inflammatory and non-inflammatory acne breakouts.

Journal of Cosmetic and Laser Therapy, 2006Journal of Cosmetic Dermatology, 2024

Where does this treatment go in a skincare routine for oily acne-prone skin?

This treatment goes in the evening routine, as treatments with active ingredients are placed then for simplicity and extra safety around sun exposure. It is used after cleansing and toning, and before moisturizing.

Can I use this treatment with retinol, and in what order?

It is best to use this treatment and retinol on alternating nights or times of day rather than together, because combining strong exfoliating ingredients may increase the likelihood of skin irritation. When using both in your routine, apply this treatment first on clean skin, let it absorb fully, and follow with your retinol product on a separate night.

How often should I use this treatment?

Start using this treatment once a week in your evening routine, and if your skin handles it well and you see good results, you can carefully use it more often. It is a great fit for your oily acne-prone skin because niacinamide and betaine salicylate help regulate oil and gently exfoliate for a smoother texture.

Can this treatment clog pores, cause breakouts or purging for oily acne-prone skin?

This treatment is unlikely to clog pores or cause breakouts for oily acne-prone skin, as its formula offers an excellent fit with ingredients that help regulate oil and provide mild exfoliation. The formulation is safe with no harsh ingredients, though you may experience a tingling sensation which is common with this product type.

Is this treatment fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

What the research says

  • Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

    Journal of Cosmetic Dermatology, 2021

  • Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

    The Journal of Investigative Dermatology, 2008

  • Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

    Dermatologic Surgery, 2005

  • Electrospun poly (vinyl butyral-co-vinyl alcohol-co-vinyl acetate) patches loaded with evening primrose oil applied to the forearm of volunteers for 6 hours increased skin moisture, with pore size, shape, and fiber diameter influencing oil transport.

    Biomaterials Advances, 2022

  • A topical preparation containing urea, sunflower oil, evening primrose oil, wheat germ oil, and sodium pyruvate led to clinical improvement after a month in diverse hyperkeratotic skin conditions except pityriasis lichenoides.

    Medicina Cutanea Ibero-latino-americana, 1986

  • Oenothera biennis cell culture aqueous extract promoted matrix collagen contraction, actin polymerization, and essential extracellular matrix protein production by increasing MYLK gene expression in in vitro, cell, and ex vivo skin aging models.

    Metabolites, 2021

  • Topical application of Bifidobacterium-fermented soy milk extract significantly restored elasticity and viscoelasticity, increased hyaluronic acid content, and improved hydration and thickness in mouse skin, and lessened the decrease in skin elasticity in human skin compared to baseline.

    Journal of Cosmetic Science, 2004

  • Genistein and daidzein inhibited UVB-induced hydrogen peroxide production in keratinocytes acting as free radical scavengers with negligible skin disruption, whereas glycitein showed no protective activity.

    International Journal of Pharmaceutics, 2008

  • A water-in-oil microemulsion vehicle significantly enhanced the intradermal delivery of genistein, daidzein, and biochanin A in excised guinea pig and Yucatan micropig skin, with genistein exhibiting the most marked increase in skin accumulation and effectively preventing UV irradiation-induced erythema formation.

    Chemical & Pharmaceutical Bulletin, 2010

  • Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months.

    The Journal of Dermatology, 2008

  • Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants.

    International Journal of Molecular Sciences, 2026

  • Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts.

    International Journal of Molecular Sciences, 2021

Ingredients

Water, Dipropylene Glycol, Glycerin, 1,2-Hexanediol, Lactobacillus Extracellular Vesicles, Butylene Glycol, Niacinamide, Oenothera Biennis Flower Extract, Pueraria Lobata Root Extract, Pinus Palustris Leaf Extract, Ulmus Davidiana Root Extract, Ethylhexyl Palmitate, Sodium Polyacrylate, Hydrogenated Polydecene, Caprylyl Capryl Glucoside, C12-14 Alketh-12, Hydrolyzed Sponge, Calcium Silicate, Sodium Silicate, Campsis Grandiflora Flower Extract, Ethylhexylglycerin, Adenosine, Disodium Edta, Panthenol, Betaine Salicylate, Citric Acid, Gluconolactone

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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Prices checked 10 Oct – 6 Nov 2026

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

How does it fit your skin?

Scan your face, then any product: Lovi shows how well it fits you and what fits even better.

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