Meaningful Beauty Youth Activating Melon Serum for mature skin

How to apply

Questions and answers

What the research says

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• A night cream containing melatonin, carnosine, and Helichrysum italicum extract reduced oxidative stress ex vivo and improved hydration, reduced transepidermal water loss, decreased wrinkles and spots, and lowered skin reactivity in 117 individuals over up to 12 weeks of nightly use.

  Dermatology and Therapy, 2020

• Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone.

  Dermatologic Therapy, 2022

• Polypropylene non-woven fabric impregnated with H. italicum extract using ethanol as a cosolvent demonstrated significantly greater potential for skin protection compared to other investigated samples on artificially irritated human skin without causing irritation or redness.

  Journal of Ethnopharmacology, 2023

• Topical application of TAT-SOD significantly suppresses UVB-induced erythema formation, blood flow rise, and apoptotic sunburn cell formation in human volunteers compared to a vehicle control.

  European Journal of Pharmaceutics and Biopharmaceutics, 2016

• Topical superoxide dismutase formulations maintained physical stability and enzymatic activity for 6 months at 4 and 30 degrees C, and effectively inhibited UVB-induced skin erythema for 48 hours, whereas formulations combined with alpha-tocopherol were unstable.

  European Journal of Pharmaceutics and Biopharmaceutics, 2007

• Fusion of human Cu,Zn-superoxide dismutase with a 9-polylysine protein transduction domain or Tat domain enabled efficient cellular and skin penetration, protected fibroblast cells against paraquat-induced oxidative stress, and showed higher efficacy for 9Lys-SOD compared to Tat-SOD.

  Molecules and Cells, 2002

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.

  Journal of Cosmetic Dermatology, 2020

• Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.

  International Journal of Cosmetic Science, 2001

• Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects.

  Journal of Drugs in Dermatology, 2012

• Supramolecular carnosine improves skin reactivity, upregulates Nrf2 expression, activates antioxidant defenses, and reduces AGE levels while demonstrating whitening efficacy in cells and clinical tests compared to conventional carnosine.

  Advanced Healthcare Materials, 2024

• A targeted skincare regimen containing active ingredients such as rhodophyceae extract, ergothioneine, and L-carnosine significantly reduced transepidermal water loss by 24.09%, improved skin elasticity, and decreased redness, dryness, and desquamation in thirty-five female Chinese participants over 4 weeks following advanced optimal pulse technology treatment.

  International Journal of Cosmetic Science, 2025

• Topical application of carnosine and a novel facial cream containing carnosine protects against methylglyoxal-induced glycation by significantly reducing levels of advanced glycation end-products carboxymethyl-lysine and pentosidine in both the epidermis and reticular dermis of human skin explants.

  Skin Pharmacology and Physiology, 2018

• Application of creams and emulgels containing immortelle extract and hemp oil increased skin hydration and reduced TEWL in 25 healthy volunteers compared to placebo samples and a non-treated control, with emulgels demonstrating enhanced herbal active delivery and better sensory properties than creams.

  Pharmaceutics, 2021

• Neryl acetate mediates a large part of Corsican Helichrysum italicum essential oil activity by upregulating genes involved in epidermal differentiation, skin barrier formation, and ceramide synthesis, leading to increased involucrin, total lipids, and ceramides in human skin explant models compared to the essential oil.

  PloS One, 2023

• Helichrysum italicum oil combined with electrospun nanofibers increased cell proliferation and viability while activating a molecular rejuvenation program in human skin stem cells and BJ fibroblasts exposed to UV stress compared to untreated controls.

  International Journal of Molecular Sciences, 2024

Why other serums fit mature skin better

• Caviar oil enhanced adipocyte differentiation in vitro, reduced MMP expression while increasing collagen and elastin formation ex vivo, and improved skin moisture, elasticity, and density in 102 participants over four weeks of Cavi Balm usage compared to baseline.

  In Vivo, 2023

• Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants.

  Journal of Cosmetic Dermatology, 2026

• A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers.

  Journal of Cosmetic Dermatology, 2020

Ingredients

Water, Glycerin, Isononyl Isononanoate, Propanediol, Betaine, Pentylene Glycol, Dextrin Palmitate, Cucumis Melo Cantalupensis Callus Extract, Helichrysum Italicum Extract, Pancratium Maritimum Extract, Orchid Stem Extract Root Leaf, Carnosine, Diglucosyl Gallic Acid, Disodium Edta, Amodimethicone, 1,2-Hexanediol, Sodium Hyaluronate, Triethoxycaprylylsilane, Palmitic Acid, Sorbitan Oleate, Ethylene Propylene Styrene Copolymer, Carbomer, Sodium Hydroxide, Phenoxyethanol, Caprylyl Glycol, Titanium Dioxide, Iron Oxides

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.