DRMTLGY Peptide Night Cream for mature skin
Peptides
Ceramides
Shea Butter
Tocopherol Vitamin E
Allantoin
High
- HighNormal Skin Fit
- HighEffectiveness
- ExcellentSafety
A great choice for mature skin; a few moisturizers fit it even better.
This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Excellent for your normal skin, this cream effectively targets wrinkles and fine lines with peptides like Palmitoyl Tetrapeptide-7 and Trifluoroacetyl Tripeptide-2, which promote collagen synthesis and skin elasticity.
- The inclusion of ceramides and cholesterol further supports your skin barrier, enhancing overall skin health and emollient action.
- The product is safe for your skin, as it contains soothing ingredients like shea butter and ceramides, and lacks any harsh or prohibited substances.
How to apply
- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
People Say
★4.9Overall rating based on 2.4k+ reviewsBased on a very large amount of data, this fragrance-free night cream is highly regarded for its rich yet non-greasy texture, providing deep hydration and plumping effects. Users frequently report improvements in skin texture, reduced fine lines, and a strengthened moisture barrier, making it suitable for sensitive and aging skin types. Some users find the jar packaging unhygienic, and a few with very dry skin may require additional moisture, while others note it can be too heavy for daytime use. Availability can also be a concern due to frequent sell-outs.
Highlights
Deep hydration Mostly Mentioned
- “quenches skin's thirst”
- “woke up glowing”
- “no more dry patches”
Gentle formula Often Mentioned
- “no irritation”
- “fragrance-free”
Non-greasy texture Often Mentioned
- “soaks right in”
- “fluffy texture”
- “lightweight but rich”
Anti-aging benefits Sometimes Noted
- “softens fine lines”
- “skin looks younger”
- “improves skin elasticity”
Value for money Sometimes Noted
- “better than high-end”
- “great price point”
- “affordable luxury”
Jar packaging Sometimes Noted
- “wish it had a pump”
- “don't like dipping fingers”
- “prefer airless dispenser”
Availability issues Rarely Noted
- “shipping takes time”
- “only available online”
- “sold out frequently”
Not rich enough Rarely Noted
- “need to layer oil”
- “not enough for winter”
- “dried out by morning”
Too heavy for day Rarely Noted
- “too thick for day”
- “shiny under makeup”
- “strictly a night cream”
Sources: lovi.care, drmtlgy.com, amazon.com, reddit.com, youtube.com, makeupalley.com, and more
Questions and answers
What makes DRMTLGY Peptide Night Cream a great fit for mature skin?
This cream is a great fit because it uses peptides like Palmitoyl Tetrapeptide-7 to target wrinkles and fine lines while helping improve skin firmness. It also includes ceramides and shea butter to support your skin barrier and keep your skin feeling soft and smooth.
Journal of Cosmetic Dermatology, 2015International Journal of Cosmetic Science, 2026
Which ingredients make this cream a good fit for mature skin?
This cream is a great fit for mature skin because it contains peptides like palmitoyl tetrapeptide-7, which help smooth out fine lines and wrinkles by supporting collagen. It also includes ceramides and shea butter to strengthen the skin barrier and keep your skin soft and calm.
Journal of Cosmetic Dermatology, 2015International Journal of Cosmetic Science, 2026
What do Peptides do for mature skin?
Peptides help mature skin by signaling skin cells to boost collagen production, which improves firmness and smooths out fine lines. They are generally safe to use daily, though their ability to deliver results depends heavily on how well the formula can sink into the skin.
International Journal of Cosmetic Science, 2009Biomolecules, 2025
What do Ceramides do for mature skin?
Ceramides help keep mature skin hydrated and smooth by repairing the outer moisture barrier and supporting water retention. This type of ingredient helps improve skin texture and elasticity while reducing dryness, which makes it particularly useful for aging skin that tends to lose moisture easily.
Dermatologic Therapy, 2019International Journal of Immunopathology and Pharmacology, 2008
Where does this cream go in a skincare routine for mature skin?
This cream goes in the evening routine as a moisturizing treatment after cleansing, and in the morning routine as a standard moisturizer before SPF. It helps smooth fine lines and supports the skin barrier using peptides and ceramides.
Journal of Cosmetic Dermatology, 2015Scientific Reports, 2022
Can I use this cream with retinol, and in what order?
Yes, you can use this cream with retinol, and applying it after your retinol treatment helps soothe your skin and strengthen your moisture barrier. Using a barrier-supporting moisturizer alongside active treatments is unlikely to cause irritation and may improve your skin's tolerance.
How often should I use this cream?
You can use this cream twice a day to help smooth fine lines and keep your skin soft. Regular use is unlikely to irritate mature skin and supports your skin barrier over time.
Journal of Cosmetic Dermatology, 2020Health Science Reports, 2021
Can this cream clog pores, cause breakouts or purging for mature skin?
This cream is unlikely to clog pores or cause breakouts for mature skin because it features a safe formula with soothing ingredients like shea butter and ceramides, without harsh substances. It helps keep your skin calm while smoothing out fine lines and supporting your skin barrier.
Can I use this cream around the eyes or on my body?
You can use this cream safely around your eyes and on your body because its gentle formula and nourishing ingredients like shea butter and ceramides are well tolerated by thinner skin areas. While the product is a great fit for mature skin to help smooth lines and support the skin barrier, you should test a small patch first since the skin around the eyes is especially delicate.
Surgical and Radiologic Anatomy, 2002Journal of Cosmetic Dermatology, 2015
Is this cream fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol. Cetyl alcohol is a fatty alcohol, which soften the skin.
What the research says
A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo.
Journal of Cosmetic Dermatology, 2015Palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-10 significantly increased type III collagen levels in human dermal fibroblasts following UV exposure, with their combination demonstrating a greater effect in vitro and enhancing type I, III, and IV collagen levels in ex vivo skin tissues compared to individual components.
International Journal of Cosmetic Science, 2026Application of Body Lotion for 5 weeks on cosmetic dry skin improved barrier properties, increased levels of cholesterol, ceramides, and long-chain fatty acids, increased beneficial skin bacteria, and enhanced microbiome functional potential compared to baseline.
Scientific Reports, 2022A combination cream of stimu-tex AS and saccharide isomerate reduced erythema, increased skin capacitance, and reduced transepidermal water loss compared to placebo in 20 subjects after fractional CO2 laser procedure without causing serious adverse events.
Lasers in Medical Science, 2025A skin barrier restoring cream with shea butter, silkflo, and vitamin E increased type I procollagen synthesis, enhanced antioxidant enzyme activity, decreased reactive oxygen species generation, and promoted hyaluronic acid production in H2O2-stimulated human keratinocyte cells compared to untreated cells.
International Journal of Cosmetic Science, 2025Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls.
Journal of Cosmetic Dermatology, 2025Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate.
Contemporary Clinical Trials Communications, 2021Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin.
Journal of Cosmetic Dermatology, 2024Topical gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not improve postoperative comfort regarding swelling and pain, but improved the wound's aesthetic appearance following impacted lower third molar extraction compared to no gel.
Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo.
Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020An overnight patch containing Allium cepa extract and allantoin safely promotes scar healing after dermatologic surgery, resulting in significantly greater reductions in observer- and patient-assessed POSAS scores compared to no treatment.
Aesthetic Plastic Surgery, 2018
Ingredients
Water, Glyceryl Stearate, Propanediol, C12-15 Alkyl Benzoate, Glycerin, Isopropyl Palmitate, Undecane, Butyrospermum Parkii Butter Shea Butter, Caprylic Capric Triglyceride, Cetyl Alcohol, Dimethicone, Peg-100 Stearate, Ceramide Eop, Ceramide Ap, Palmitoyl Tetrapeptide-7, Ceramide Np, Palmitoyl Tripeptide-1, Trifluoroacetyl Tripeptide-2, Palmitoyl Tripeptide-5, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Allantoin, Phytosphingosine, Cholesterol, Tridecane, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Butylene Glycol, Glycol Distearate, Ethylhexylglycerin, Potassium Cetyl Phosphate, Carbomer, Sodium Hydroxide, Disodium Edta, Sodium Lauroyl Lactylate, Polysorbate 20, Dextran, Xanthan Gum, Phenoxyethanol, Magnesium Chloride
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
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