DRMTLGY Peptide Night Cream for dry skin
Peptides
Ceramides
Shea Butter
Tocopherol Vitamin E
Allantoin
Superior
- HighDry Skin Fit
- HighEffectiveness
- ExcellentSafety
One of the best moisturizers for dry skin.
This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Excellent suitability for your dry skin is provided by ceramides, peptides, and shea butter, which deeply hydrate and repair your skin barrier, improving elasticity and reducing fine lines. Glycerin and Butyrospermum Parkii Butter work synergistically to offer humectant and emollient actions, supporting your skin barrier and combating dryness. The product is safe for your skin, containing no harsh ingredients and including soothing components like shea butter and ceramides.
How to apply
- Could be used as part of your AM or PM routine. Start using it 3 times a week and work your way up to daily use.
- Apply your moisturizer after your toner and before your sunscreen in the morning. At night, use it as the final step after your serum.
- Gently press a small amount of the moisturizer into your skin. Avoid rubbing to keep your dry skin happy.
- Apply the moisturizer on slightly damp skin to help lock in extra hydration. This is great for soothing dry and flaky areas .
- Avoid the sensitive eye area and do a patch test before your first use .
People Say
★4.9Overall rating based on 2.4k+ reviewsBased on a very large amount of data, this fragrance-free night cream is highly regarded for its rich yet non-greasy texture, providing deep hydration and plumping effects. Users frequently report improvements in skin texture, reduced fine lines, and a strengthened moisture barrier, making it suitable for sensitive and aging skin types. Some users find the jar packaging unhygienic, and a few with very dry skin may require additional moisture, while others note it can be too heavy for daytime use. Availability can also be a concern due to frequent sell-outs.
Highlights
Deep hydration Mostly Mentioned
- “quenches skin's thirst”
- “woke up glowing”
- “no more dry patches”
Gentle formula Often Mentioned
- “no irritation”
- “fragrance-free”
Non-greasy texture Often Mentioned
- “soaks right in”
- “fluffy texture”
- “lightweight but rich”
Anti-aging benefits Sometimes Noted
- “softens fine lines”
- “skin looks younger”
- “improves skin elasticity”
Value for money Sometimes Noted
- “better than high-end”
- “great price point”
- “affordable luxury”
Jar packaging Sometimes Noted
- “wish it had a pump”
- “don't like dipping fingers”
- “prefer airless dispenser”
Availability issues Rarely Noted
- “shipping takes time”
- “only available online”
- “sold out frequently”
Not rich enough Rarely Noted
- “need to layer oil”
- “not enough for winter”
- “dried out by morning”
Too heavy for day Rarely Noted
- “too thick for day”
- “shiny under makeup”
- “strictly a night cream”
Sources: lovi.care, drmtlgy.com, amazon.com, reddit.com, youtube.com, makeupalley.com, and more
Questions and answers
What makes DRMTLGY Peptide Night Cream one of the best fits for dry skin?
This cream is an exceptional fit for dry skin because its blend of ceramides, peptides, and shea butter deeply hydrates and repairs your skin barrier while improving elasticity. Glycerin and shea butter work together to combat dryness and keep your skin feeling soft and smooth.
Which ingredients make this cream a good fit for dry skin?
Ceramides, peptides, and shea butter make this cream a great fit because they deeply hydrate your skin and repair its barrier. They work alongside glycerin to combat dryness while soothing your skin and improving elasticity.
What do Peptides do for dry skin?
Peptides help dry skin by supporting skin barrier health and improving moisture retention. Regular use may also enhance skin firmness and smooth out the texture of dry skin over time.
What do Ceramides do for dry skin?
Ceramides help keep dry skin soft by strengthening the outer barrier and locking in hydration. This improvement in barrier integrity reduces dryness and protects against irritation.
The British Journal of Dermatology, 2022Dermatologic Therapy, 2019
Where does this cream go in a skincare routine for dry skin?
This cream goes in the evening routine as a moisturizing treatment after your cleanser and before your moisturizer. It is very well suited for dry skin, helping to deeply hydrate and repair your skin barrier with ceramides, peptides, and shea butter.
Can I use it with retinol, and in what order?
You can use this cream with retinol, applying it after your retinol treatment to help your skin stay soft and comfortable. Using a barrier-enhancing moisturizer alongside retinoids is unlikely to cause issues and may help reduce dryness while supporting your skin.
How often should I use this cream?
You can use this cream every evening as part of your nighttime routine to keep your dry skin deeply hydrated and soft. Regular daily use helps repair your skin barrier, combat dryness, and improve texture over time.
Journal of Cosmetic Dermatology, 2020Health Science Reports, 2021
Can it clog pores, cause breakouts or purging for dry skin?
This cream is unlikely to clog pores or cause breakouts on dry skin because it features nourishing ingredients like ceramides and shea butter that deeply hydrate without harsh components. It also does not contain active ingredients that typically trigger skin purging.
Can I use it around the eyes or on my body?
You can use this moisturizing treatment around your eyes and on your body, as its gentle formula is well tolerated by delicate areas. Studies on similar moisturizing ingredients show that regular application effectively hydrates and smooths skin in those regions without causing irritation.
European Journal of Pharmaceutics and Biopharmaceutics, 2014Polymers, 2023
Is this cream fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol. Cetyl alcohol is a fatty alcohol, which soften the skin.
What the research says
Application of Body Lotion for 5 weeks on cosmetic dry skin improved barrier properties, increased levels of cholesterol, ceramides, and long-chain fatty acids, increased beneficial skin bacteria, and enhanced microbiome functional potential compared to baseline.
Scientific Reports, 2022A combination cream of stimu-tex AS and saccharide isomerate reduced erythema, increased skin capacitance, and reduced transepidermal water loss compared to placebo in 20 subjects after fractional CO2 laser procedure without causing serious adverse events.
Lasers in Medical Science, 2025A skin barrier restoring cream with shea butter, silkflo, and vitamin E increased type I procollagen synthesis, enhanced antioxidant enzyme activity, decreased reactive oxygen species generation, and promoted hyaluronic acid production in H2O2-stimulated human keratinocyte cells compared to untreated cells.
International Journal of Cosmetic Science, 2025Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls.
Journal of Cosmetic Dermatology, 2025Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate.
Contemporary Clinical Trials Communications, 2021Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin.
Journal of Cosmetic Dermatology, 2024Topical gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not improve postoperative comfort regarding swelling and pain, but improved the wound's aesthetic appearance following impacted lower third molar extraction compared to no gel.
Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo.
Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020An overnight patch containing Allium cepa extract and allantoin safely promotes scar healing after dermatologic surgery, resulting in significantly greater reductions in observer- and patient-assessed POSAS scores compared to no treatment.
Aesthetic Plastic Surgery, 2018
Ingredients
Water, Glyceryl Stearate, Propanediol, C12-15 Alkyl Benzoate, Glycerin, Isopropyl Palmitate, Undecane, Butyrospermum Parkii Butter Shea Butter, Caprylic Capric Triglyceride, Cetyl Alcohol, Dimethicone, Peg-100 Stearate, Ceramide Eop, Ceramide Ap, Palmitoyl Tetrapeptide-7, Ceramide Np, Palmitoyl Tripeptide-1, Trifluoroacetyl Tripeptide-2, Palmitoyl Tripeptide-5, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Allantoin, Phytosphingosine, Cholesterol, Tridecane, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Butylene Glycol, Glycol Distearate, Ethylhexylglycerin, Potassium Cetyl Phosphate, Carbomer, Sodium Hydroxide, Disodium Edta, Sodium Lauroyl Lactylate, Polysorbate 20, Dextran, Xanthan Gum, Phenoxyethanol, Magnesium Chloride
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
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