ZO Skin Health Growth Factor Serum for mature skin
Dipeptide Diaminobutyroyl Benzylamide Diacetate
Adenosine Triphosphate
Beta-Glucan
Angelica Polymorpha Sinensis Root Extract
Hydrolyzed Sericin
High
- HighNormal Skin Fit
- HighEffectiveness
- HighSafety
A great choice for mature skin; a few serums fit it even better.
This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Highly suitable for your normal skin as Buddleja Davidii Meristem Cell Culture and Dipeptide Diaminobutyroyl Benzylamide Diacetate provide antioxidant activity and support collagen synthesis, addressing your wrinkles and fine lines.
- The inclusion of Panthenyl Triacetate and Ethyl Linoleate further enhances skin hydration and barrier function, complementing the primary anti-aging benefits.
- The product is safe for your skin, with no harsh ingredients or irritants present.
How to apply
- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
People Say
★4.5Overall rating based on 1.4k+ reviewsBased on a very large amount of data, this product is highly regarded by users with aging, dry, and sensitive skin for its hydrating and plumping effects, visibly reducing fine lines. The lightweight gel formula is frequently praised for restoring the skin's moisture barrier and improving texture. However, some users with acne-prone skin report breakouts, and the high price is a common concern.
Highlights
Lightweight gel Mostly Mentioned
- “The lightweight gel feels refreshing upon application”
- “Glides effortlessly on the skin, leaving no greasy residue”
- “Absorbs within seconds, leaving no greasy or sticky residue”
- “Feels so light weight and leaves your face feeling hydrated”
Hydrating, plumping Often Mentioned
- “Skin truly feels plumped and nourished”
- “Super hydrating and leaves the skin smooth and plump”
- “Helps hydrate dry patches and leave skin feeling supple”
- “Leaves my skin hydrated and bouncy”
Very expensive Often Mentioned
- “Premium pricing might not suit budget-conscious buyers”
- “Expensive for 1 oz”
- “Well worth the money... but it's so expensive”
- “Pricey but it's money well spent”
Gentle, soothing Sometimes Noted
- “Gentle enough for sensitive skin; no irritation”
- “Seemed to calm my skin rather than aggravate it”
- “Reduces minor irritation, ideal for sensitive skin types”
- “Calming aloe scent provided a spa-like experience”
Reduces lines Sometimes Noted
- “Softened the appearance of fine lines”
- “Annoying fine lines on my forehead and around my eyes looked diminished”
- “Helped with hydration and my fine lines”
- “Helps visibly reduce fine lines and wrinkles over consistent use”
Slow results Sometimes Noted
- “Effects do take time”
- “Requires patience; results are visible only after several weeks”
- “Deeper wrinkles remained largely unchanged, at least in the short term”
Causes breakouts Rarely Noted
- “The growth serum broke me out like I haven't broken out since high school”
- “Ingredient in it that commonly breaks people out: dimethicone”
- “Some individuals may experience increased acne or new blemishes”
Faulty pump Rarely Noted
- “Pump dispenser to be somewhat finicky”
- “Dispensing an even amount of product can be tricky”
- “Excess product dispensed often leads to waste”
Pills under makeup Rarely Noted
- “User found that it pills under a foundation”
- “Dimethicone may contribute to pilling”
- “Pilling may occur when layered with products”
Sources: lovi.care, zoskinhealth.com, reddit.com, whatsinmyjar.com, skinsort.com, dermapproved.com, and more
Questions and answers
What makes Growth Factor Serum a great fit for mature skin?
ZO Skin Health Growth Factor Serum is a great fit for mature skin because Buddleja Davidii Meristem Cell Culture and Dipeptide Diaminobutyroyl Benzylamide Diacetate help protect against damage and support collagen production to smooth out wrinkles and fine lines. Panthenyl Triacetate and Ethyl Linoleate further boost skin hydration and strengthen the moisture barrier to keep skin soft and healthy.
International Journal of Cosmetic Science, 2026International Journal of Cosmetic Science, 2010
Which ingredients make this serum a good fit for mature skin?
Buddleja Davidii Meristem Cell Culture and Dipeptide Diaminobutyroyl Benzylamide Diacetate make this serum a great fit because they provide antioxidant activity and support collagen synthesis to help smooth wrinkles and fine lines. Panthenyl Triacetate and Ethyl Linoleate further enhance skin hydration and barrier function.
International Journal of Cosmetic Science, 2010International Journal of Cosmetic Science, 2026
What does Dipeptide Diaminobutyroyl Benzylamide Diacetate do for mature skin?
Dipeptide diaminobutyroyl benzylamide diacetate helps smooth the look of wrinkles and improves overall skin quality on mature skin. It works to boost anti-aging markers, making the skin look firmer and more youthful.
What does Adenosine Triphosphate do for mature skin?
Adenosine Triphosphate helps mature skin by improving radiance, elasticity, and texture, and it may support collagen synthesis to keep skin looking firm and youthful. These benefits are especially helpful for older skin, which often needs an energy boost to maintain its natural renewal and smooth feel.
Current Issues in Molecular Biology, 2024Journal of Nanobiotechnology, 2026
Where does this serum go in a skincare routine for mature skin?
This treatment serum goes in the evening routine after cleansing and toning, and before your moisturizer. Putting treatments in the evening provides simplicity and extra safety around sun exposure.
Can I use it with retinol, and in what order?
You can use this treatment alongside retinol by applying the retinol first and following with this serum, or by using retinol in the evening and this treatment in the morning. This routine helps smooth fine lines while minimizing potential irritation.
How often should I use it?
Use this treatment in your evening routine, applying it after your cleansing toner and before your moisturizer. It is gentle enough for daily evening use to help smooth fine lines and keep your mature skin looking firm.
International Journal of Cosmetic Science, 2026Facial Plastic Surgery, 2014
Can this serum clog pores, cause breakouts or purging for mature skin?
This serum is unlikely to cause breakouts or clog pores for mature skin because it contains no harsh ingredients or heavy irritants. Reviewers occasionally report breakouts, but this happens rarely.
Is it fragrance-free and alcohol-free?
It has no drying alcohol and contains fragrance (parfum). Oleyl alcohol is a fatty alcohol, which soften the skin.
What the research says
A novel anti-aging serum containing acetyl hexapeptide-8, dipeptide diaminobutyroyl benzylamide diacetate, gluconolactone, niacinamide, and laminaria extract significantly increased anti-aging biomarkers and improved static and dynamic wrinkles as well as skin quality in clinical studies.
International Journal of Cosmetic Science, 2026Verbascoside- and teupolioside-containing extracts significantly accelerated wound healing, exhibited anti-inflammatory action, inhibited reactive oxygen species release, and suppressed chemokine and growth factor expression in cultured human keratinocytes compared to pro-inflammatory controls.
Cellular and Molecular Biology, 2007Treatment with a bioactive complex of Panthenyl triacetate and Ethyl linoleate at 3% protected human skin biopsies against UV-induced protein oxidation by 72% with pre-treatment and 78% with post-treatment, while also stimulating the expression of protein repairing enzymes compared to UV-irradiated controls.
International Journal of Cosmetic Science, 2010Panthenyl triacetate (PTA) demonstrated skin de-acetylation into panthenol, stimulated energetic and synthesis metabolic pathways, and achieved a statistically significant improvement in wound healing after 72 hours compared to saline treatment in human volunteers, outperforming panthenol in long-lasting wound healing action.
Journal of Cosmetic Science, 2012A bacterial nanocellulose wound dressing incorporating polyhexamethylene biguanide and sericin showed no skin irritation in healthy volunteers and significantly promoted wound healing with lower wound size and higher collagen formation in full-thickness rat wounds compared to controls.
Archives of Dermatological Research, 2016The application of a vitamin B12 and adenosine triphosphate complex improved skin radiance, elasticity, and texture in human participants.
Current Issues in Molecular Biology, 2024Direct delivery of intracellular adenosine triphosphate using ATP-encapsulated fusogenic small unilamellar lipid vesicles accelerated wound healing, improved granular tissue development, re-epithelialization, and increased vascular endothelial growth factor expression compared to lipid vesicles alone in adult nude mice.
American Journal of Surgery, 2007A self-powered chloroplast-driven nanophotosystem consisting of Chlorella-derived nanothylakoid units and hyaluronic acid microneedles increased mitochondrial biogenesis, adenosine triphosphate generation, and NAD(P)H pools in senescent fibroblasts, leading to increased collagen synthesis and alleviated skin photoaging.
Journal of Nanobiotechnology, 2026Skin care regimens containing beta-glucan improved hemoglobin index, skin hydration, and transepidermal water loss compared to vehicle control in 20 patients undergoing fractional laser therapy.
Journal of Cosmetic Dermatology, 2021Treatment with topical formulations containing beta-glucan combined with nanofractional radiofrequency plus magnetic nanofractional radiofrequency showed the best efficacy and was tolerable and effective in Chinese women with abdominal stretch marks compared to control groups.
Dermatology and Therapy, 2023Topical beta-glucan mildly improved striae gravidarum, 1565-nm non-ablative fractional laser showed better results than topical beta-glucan, and the combined strategy further improved striae gravidarum atrophy compared to single treatment.
The Journal of Dermatology, 2022Angelica sinensis essential oil at 5%-10% demonstrated significant anti-acne effects comparable to adapalene gel with reduced side effects in mice by suppressing Cutibacterium acnes and downregulating IL-1β.
Journal of Ethnopharmacology, 2026An Angelica sinensis extract containing 1% ligustilide demonstrated anti-inflammatory, antioxidant, anti-senescence, matrix-supportive, and antimicrobial effects in human keratinocytes and dermal fibroblasts.
Frontiers in Pharmacology, 2026Topical application of Angelica sinensis extract induced noticeable hair regrowth, restored hair shaft lengths and follicle size, and decreased apoptotic cells in C57BL/6 mice.
The American Journal of Chinese Medicine, 2014Bacterial cellulose wound dressing containing silk sericin and PHMB improved wound quality and reduced pain compared to Bactigras in patients with split-thickness skin graft donor-site wounds.
Archives of Dermatological Research, 2018Topical application of sericin gels increased skin intrinsic moisturization, hydroxyproline content, and epidermal hydration while decreasing transepidermal water loss and skin impedance in healthy human volunteers.
Journal of Cosmetic Dermatology, 2005Silk sericin-releasing bacterial nanocellulose gel demonstrated improved mechanical properties, controlled sericin release, non-cytotoxicity on L929 and HaCaT cells, and non-irritancy in subcutaneous tissue compared to a commercially available paper mask.
BMC Biotechnology, 2014
Ingredients
Water, Cyclopentasiloxane, Dipropylene Glycol, Propylene Glycol, Dimethicone, Glycerin, Dimethicone Crosspolymer, Dimethicone Peg-10 15 Crosspolymer, Peg-12 Dimethicone Crosspolymer, Butylene Glycol, Dimethicone Vinyl Dimethicone Crosspolymer, Sodium Phosphate, Panthenyl Triacetate, Magnesium Sulfate, Hydrolyzed Sericin, Ethyl Linoleate, Buddleja Davidii Meristem Cell Culture, Angelica Polymorpha Sinensis Root Extract, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Lactobacillus Panax Ginseng Root Extract Ferment Filtrate, Disodium Acetyl Glucosamine Phosphate, Acetyl Tyrosine, Dimethiconol, Oleyl Alcohol, Proline, Parfum, Tocopherol, Beta-Glucan, Adenosine Triphosphate, Hydrolyzed Protein, Sodium Chloride, Xanthan Gum, Phenoxyethanol
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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