Some By Mi Snail Truecica Miracle Repair Low pH Gel Cleanser for combination skin

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Questions and answers

What the research says

• Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components.

  Molecules, 2023

• Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements.

  Indian Journal of Pharmaceutical Sciences, 2016

• A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability.

  The Journal of Dermatological Treatment, 2017

• Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment.

  American Journal of Clinical Dermatology, 2002

• A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment.

  Journal of Cosmetic Dermatology, 2025

• A facial serum containing snail secretion filtrate, Calendula officinalis, and Glycyrrhiza glabra root extract significantly reduced inflammatory acne lesions compared to placebo in 66 participants with mild-to-moderate maskne over 12 weeks.

  Journal of Cosmetic Dermatology, 2022

• Cruelty-free extracted snail slime promotes fibroblast viability, triggers recovery through Erk protein activation, reduces cyclooxygenase-2 expression, and increases angiopoietin 1 gene expression and collagen I release in skin cell populations.

  Molecules, 2023

• Topical treatment with Snail Secretion Filtrate significantly improves the speed and percentage of wound area closure, enhances proliferation and tissue remodeling, and reduces inflammation in a full-thickness excisional wound model in mice compared to untreated controls.

  Veterinary Sciences, 2021

• Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing.

  Journal of Alternative and Complementary Medicine, 2020

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects.

  Journal of Cosmetic Dermatology, 2019

• Combining 755 nm alexandrite laser with topical licorice gel significantly reduces terminal hair counts compared to alexandrite laser with placebo in women with idiopathic hirsutism.

  Evidence-based Complementary and Alternative Medicine, 2015

• Licochalcone A activated Nrf2 signaling, elevated cytoprotective enzymes, increased the reduced-to-oxidized glutathione ratio, and decreased reactive oxygen species in human fibroblasts and neutrophils, while a LicA-rich licorice extract lowered UVA-induced oxidative processes in vivo.

  Experimental Dermatology, 2015

• Bioactive glycyrrhizic acid and oxymatrine ionic liquid self-assembled nanomicelles significantly promoted the transdermal permeation, subcutaneous retention, and anti-photoaging efficacy of palmitoyl pentapeptide-4 in cellular and animal models compared to unformulated peptide.

  Advanced Science, 2025

Ingredients

Water, Lauryl Hydroxysultaine, Disodium Cocoamphodiacetate, Sodium Chloride, Potassium Cocoyl Glycinate, Acrylates Copolymer, Sodium Methyl Cocoyl Taurate, Potassium Cocoate, Butylene Glycol, Benzyl Glycol, Citric Acid, Bergamot Oil Fruit, Ethylhexylglycerin, Hexylene Glycol, Disodium Edta, Salvia Officinalis Oil, Betula Platyphylla Japonica Juice, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Camellia Sinensis Leaf Extract, Agrimonia Eupatoria Extract, Panthenol, 1,2-Hexanediol, Centella Asiatica Extract, Perilla Frutescens Leaf Extract, Melaleuca Alternifolia Tree Leaf Extract, Phenoxyethanol, Glycine, Dipropylene Glycol, Saponaria Officinalis Extract, Serine, Glutamic Acid, Kigelia Africana Fruit Extract, Aspartic Acid, Caprylic Capric Triglyceride, Leucine, Alanine, Lysine, Arginine, Asiaticoside, Tyrosine, Phenylalanine, Asiatic Acid, Madecassic Acid, Threonine, Proline, Valine, Isoleucine, Pentylene Glycol, Phosphatidylcholine, Platycodon Grandiflorum Root Extract, Poria Cocos Extract, Coix Lacryma-Jobi Ma-Yuen Seed Extract, Paeonia Albiflora Root Extract, Histidine, Madecassoside, Cysteine, Methionine, Polygonatum Odoratum Extract, Scutellaria Baicalensis Root Extract, Astragalus Membranaceus Root Extract, Angelica Gigas Extract, Cornus Officinalis Fruit Extract, Artemisia Vulgaris Extract, Rehmannia Glutinosa Root Extract, Ceramide Np, Bifida Lysate Ferment, Lactobacillus Lysate Ferment, Lactococcus Lysate Ferment, Limonene, Linalool

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.