Senallis Hyaluronic Acid Serum for mature skin
Sodium Hyaluronate
Glycerin
Citric Acid
Phenoxyethanol
Ethylhexylglycerin
Average
- AverageNormal Skin Fit
- AverageEffectiveness
- ExcellentSafety
Works for mature skin; other moisturizers fit it better.
This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate moisturizing for your normal skin, as glycerin and sodium hyaluronate provide hydration beneficial for wrinkles and fine lines.
- The humectant action of glycerin and sodium hyaluronate is suitable for normal skin, though higher concentrations could yield more optimal results for your concerns.
- The product is safe for your skin, with no risks of irritation due to the absence of harsh ingredients and the presence of soothing components.
How to apply
- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
Questions and answers
How well does Senallis Hyaluronic Acid Serum work for mature skin?
Senallis Hyaluronic Acid Serum works for mature skin by offering moderate hydration that helps with wrinkles and fine lines, though other products fit it better. To give mature skin the best results, a product of this type needs higher concentrations of hydrating ingredients and effective anti-wrinkle components.
Clinical, Cosmetic and Investigational Dermatology, 2017Dermatologic Therapy, 2022
Which ingredients make this serum a good fit for mature skin?
Sodium hyaluronate and glycerin make this serum a good fit by providing hydration that helps smooth wrinkles and fine lines on mature skin. To achieve the best results on mature skin, a moisturizing treatment needs higher concentrations of hydrating ingredients alongside skin-repairing components and nourishing extracts.
Clinical, Cosmetic and Investigational Dermatology, 2017Dermatologic Therapy, 2022
What does Hyaluronic Acid do for mature skin?
Hyaluronic acid helps mature skin by deeply boosting moisture, improving elasticity, and smoothing the appearance of fine lines and wrinkles. Regular use keeps the skin looking plump and soft while supporting overall firmness and hydration.
Journal of Drugs in Dermatology, 2011Skin Research and Technology, 2024
What does Glycerin do for mature skin?
Glycerin helps keep mature skin feeling soft and smooth by drawing moisture into the outer layer and locking it in. This daily hydration boost supports the skin barrier, keeping dry areas comfortable and protected against irritation.
The British Journal of Dermatology, 2008Clinical, Cosmetic and Investigational Dermatology, 2017
Where does this serum go in a skincare routine for mature skin?
This treatment goes in the evening routine after cleansing and before moisturizing. Mature skin needs a product of this type to provide higher concentrations of hydrating ingredients like glycerin and sodium hyaluronate to better address wrinkles and fine lines.
Can I use it with retinol, and in what order?
You can use this serum with retinol by applying the serum first to give your skin a boost of hydration, followed by your retinol. This product is safe and unlikely to cause irritation, making it a gentle helper alongside your anti-aging routine.
How often should I use this serum?
You can use this serum in your evening routine, applying it after cleansing and before your moisturizer. Some moisturizing treatments of this type can also be used in the morning or twice a day if your skin tolerates them well.
Journal of Cosmetic Dermatology, 2020Health Science Reports, 2021
Can it clog pores, cause breakouts or purging for mature skin?
This serum is unlikely to clog pores or cause breakouts for mature skin. It features a lightweight water-based formula with gentle ingredients that hydrate without heavy oils.
Can I use it around the eyes or on my body?
You can safely use this serum around the eyes and on the body because it has a gentle formula with no harsh ingredients. While it provides moderate hydration, mature skin often benefits more from products featuring higher concentrations of active hydrators and firming ingredients.
What the research says
A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone.
Dermatologic Therapy, 2022Hyaluronic acid extracts are safe and efficacious products for skin repair when used in tissue regeneration alone or in combination with herbal or Western medicine.
Journal of Pharmacy & Pharmaceutical Sciences, 2015Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.
Journal of Drugs in Dermatology, 2011Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.
Clinical Oral Investigations, 2022Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.
BMC Oral Health, 2019The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.
Journal of Cosmetic Dermatology, 2020Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.
International Journal of Cosmetic Science, 2001Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects.
Journal of Drugs in Dermatology, 2012A novel composition containing salicylic acid, capryloyl salicylic acid, HEPES, glycolic acid, citric acid, and dioic acid showed similar tolerance and efficacy compared with clindamycin 1% and benzoyl peroxide 5% gel in subjects with acne vulgaris.
Journal of Drugs in Dermatology, 2013Daily treatment with a facial serum containing multiple acids reduced post-inflammatory hyperchromia lesion grade and number by 29.4% at 56 days, and decreased skin oiliness by 30.7% at 7 days in Brazilian patients with acne vulgaris.
Journal of Cosmetic Dermatology, 2021Topical 20% citric acid lotion increases viable epidermal thickness and dermal glycosaminoglycan content in sun-damaged skin compared to vehicle alone.
Dermatologic Surgery, 1997
Ingredients
Distilled Water, Glycerin, Sodium Hyaluronate, Phenoxyethanol, Ethylhexylglycerin, Citric Acid, Potassium Sorbate
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Cosmetic chemist, cosmetologist, aesthetic products developer
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PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
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Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Specialist dermatologist, MBBS, MD, IFAAD
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Elina Nazarenko, MD
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Victoria Derkova, MS
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