REJURAN Rejuran® Healer Turnover Ampoule for mature skin
C-PdrnAverage
- HighNormal Skin Fit
- AverageEffectiveness
- HighSafety
Works for mature skin; other serums fit it better.
This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- This product offers moderate benefits for your normal skin, with arbutin and niacinamide working to brighten and even skin tone, while glycerin and hyaluronic acid provide essential hydration. It lacks specialized ingredients to effectively target your primary concern of wrinkles and fine lines.
- The formula is highly compatible with normal skin due to humectant ingredients like glycerin and hyaluronic acid, and arbutin helps regulate melanogenesis for improved radiance.
- The safety profile is excellent, with aloe barbadensis leaf juice and bisabolol providing soothing benefits and no harsh ingredients present, making it suitable for normal skin without irritation risks.
How to apply
- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
People Say
★4.8Overall rating based on 500+ reviewsUsers frequently report achieving a radiant "glass skin" appearance and deep hydration with this ampoule, noting significant improvements in skin texture and plumpness. It is often praised for its effectiveness in repairing damaged skin barriers, soothing redness, and aiding in the healing of acne scars. A small number of users with oily skin have found it to be slightly heavy for daytime application.
Highlights
Hydration and glow Mostly Mentioned
- “leaves my skin glowy and plump”
- “instant boost in hydration”
- “natural inner glow”
- “skin looks luminous”
Absorbs quickly Often Mentioned
- “absorbs instantly without tackiness”
- “soaks right in”
- “lightweight formula”
- “doesn't leave oily residue”
Smoother texture Often Mentioned
- “skin texture felt smoother”
- “softens rough edges”
- “makeup doesn't separate anymore”
- “pores look smaller”
Expensive product Often Mentioned
- “price is steep”
- “hard to justify full price”
- “expensive for 30ml”
- “pricier than similar products”
Calms redness Sometimes Noted
- “post-inflammatory erythema faded”
- “calms inflammation quickly”
- “healed acne marks”
Awkward packaging Sometimes Noted
- “dropper is inconvenient”
- “hard to get the last drops”
- “syringe dispenser is finicky”
- “bottle looks full but isn't”
Minor breakouts Rarely Noted
- “caused minor blemishes”
- “gave me whiteheads”
- “reactive bumps appeared”
- “broke me out slightly”
Slightly sticky Rarely Noted
- “feels a bit sticky”
- “too heavy for summer”
- “slightly viscous and tacky”
- “sticky finish on oily skin”
Sources: lovi.care, oliveyoung.com, rejuranusa.com, gopicky.com, skinsort.com, hwahae.co.kr, and more
Questions and answers
How well does Rejuran Healer Turnover Ampoule work for mature skin?
This product works moderately well for mature skin, providing basic hydration and brightening, but it lacks specialized ingredients to effectively target wrinkles and fine lines. Products of this type that fit mature skin better need to be exceptionally safe while containing high concentrations of potent antioxidants, peptides, and skin-repairing ingredients to improve elasticity and smooth lines.
The British Journal of Dermatology, 2002Clinical, Cosmetic and Investigational Dermatology, 2017
Which ingredients make this serum a good fit for mature skin?
This treatment fits mature skin moderately well because glycerin and hyaluronic acid bring essential hydration, while arbutin and niacinamide help brighten and even out skin tone. To work best for mature skin, a product of this type needs specialized ingredients that target wrinkles and fine lines and improve skin elasticity.
The British Journal of Dermatology, 2002Clinical, Cosmetic and Investigational Dermatology, 2017
What does C-Pdrn do for mature skin?
Where does this serum go in a skincare routine for mature skin?
Apply this treatment in your evening routine after cleansing and before moisturizing. Mature skin also needs ingredients like retinoids, peptides, or antioxidants to effectively target wrinkles and fine lines.
Can I use this serum with retinol, and in what order?
You can use this treatment alongside retinol by applying the treatment first and following with your retinol. Because this product is gentle and hydrating, it is unlikely to cause irritation when layered into a routine containing stronger active ingredients.
How often should I use this serum?
Use this treatment in your evening routine for simplicity and extra safety around sun exposure. Because it lacks specialized ingredients to target wrinkles and fine lines, mature skin needs a product of this type that also includes powerful firming and anti-aging ingredients like retinol, peptides, or growth factors.
Can this serum clog pores, cause breakouts or purging for mature skin?
This serum is unlikely to cause breakouts or clog pores for mature skin, as it has a very low risk of minor breakouts and contains no harsh ingredients. Its gentle formula is well-tolerated, though mature skin also needs specialized ingredients like retinol or peptides to effectively target wrinkles and fine lines.
Is this serum fragrance-free and alcohol-free?
It has no drying alcohol and contains fragrance (benzyl alcohol).
What the research says
Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer.
The British Journal of Dermatology, 2002A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Topical application of Low-Peony PDRN enhanced barrier recovery and improved periorbital skin elasticity in human subjects.
International Journal of Molecular Sciences, 2025Polydeoxyribonucleotide promotes skin regeneration by increasing ERK phosphorylation, collagen accumulation, and cell proliferation and migration in fibroblasts while inhibiting ERK phosphorylation and inflammatory cytokine expression in keratinocytes.
Molecular Medicine Reports, 2023A topical mixture of polydeoxyribonucleotide, vitamin C, and niacinamide delivered via a microneedling therapy system decreased skin pigmentation and increased skin elasticity by attenuating melanogenesis and the destruction of collagen and elastin fibers in a UV-B-radiated animal model.
Molecules, 2022
Why other serums fit mature skin better
Caviar oil enhanced adipocyte differentiation in vitro, reduced MMP expression while increasing collagen and elastin formation ex vivo, and improved skin moisture, elasticity, and density in 102 participants over four weeks of Cavi Balm usage compared to baseline.
In Vivo, 2023Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants.
Journal of Cosmetic Dermatology, 2026A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers.
Journal of Cosmetic Dermatology, 2020
Ingredients
Blackberry Leaf Extract, Glycyrrhiza Glabra Callus Culture Extract Licorice Callus Culture Extract, Calendula Officinalis Flower Extract, Aloe Barbadensis Leaf Juice, Blueberry Fruit Extract, Morus Nigra Fruit Extract Morus Alba Fruit Extract, Arbutin, Butylene Glycol, Glycerin, Polysorbate 20, Hydrolyzed Dna, Hyaluronic Acid, Carbomer, Xanthan Gum, Adenosine, Tocopheryl Acetate, Niacinamide, Bisabolol, Peg-6, Phenoxyethanol, Caprylyl Glycol, Ethylhexylglycerin, Hexylene Glycol, Benzyl Alcohol, 12-Hexanediol, Dipropylene Glycol, Sodium Chloride, Trehalose, Urea
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
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Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Specialist dermatologist, MBBS, MD, IFAAD
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Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
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Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
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