Perricone MD High Potency Hyaluronic Intensive Hydrating Serum for mature skin
Sodium Hyaluronate
Niacinamide
Squalane
Ceramide Np
Acetyl Glucosamine
Superior
- HighNormal Skin Fit
- SuperiorEffectiveness
- ExcellentSafety
One of the best moisturizers for mature skin.
This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Excellent for your normal skin, this serum effectively addresses wrinkles and fine lines with Acetyl Tetrapeptide-11 and Acetyl Tetrapeptide-9, which promote collagen synthesis and skin elasticity. Niacinamide and Glycerin further support skin health by providing soothing and hydrating benefits.
- The high concentrations of sodium hyaluronate crosspolymer and sodium hyaluronate ensure excellent hydration, plumping the skin and reducing the appearance of fine lines.
- The product is safe for your skin, with no risks of irritation due to the absence of harsh ingredients and the inclusion of soothing components.
How to apply
- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
People Say
★4.8Overall rating based on 1000+ reviewsUsers consistently praise this serum for its ability to deliver immediate and deep hydration, often noting that it visibly plumps fine lines and leaves skin feeling exceptionally soft and smooth. While the vast majority find the texture elegant and fast-absorbing, a small minority of users find it slightly sticky or heavy compared to more watery serums.
Highlights
Deep hydration Mostly Mentioned
- “Immediate deep hydration”
- “quench dehydrated skin”
- “endlessly hydrated”
- “replenish moisture”
Fast absorbing Often Mentioned
- “Absorbs quickly”
- “sinks in beautifully”
- “non-greasy”
- “no residue”
Plumps fine lines Often Mentioned
- “Plumps wrinkles”
- “softened fine lines”
- “visibly plump”
- “diminish look of lines”
Smooths texture Often Mentioned
- “Skin feels softer”
- “smooth complexion”
- “supple feeling”
- “satin veil”
High price point Often Mentioned
- “Pricey”
- “expensive”
- “splurge”
- “investment”
Gentle on skin Sometimes Noted
- “Lovely on sensitive skin”
- “very healing”
- “no irritation”
- “soothing”
Heavy texture Rarely Noted
- “Not water-like”
- “silicone feel”
- “thicker than expected”
- “too rich”
Packaging issues Rarely Noted
- “Pump broke”
- “hard to dispense”
- “bottle design”
- “product left at bottom”
Scent Rarely Noted
- “Clinical smell”
- “unpleasant scent”
- “strong odor”
- “chemical smell”
Sticky feel Rarely Noted
- “Little sticky”
- “tacky finish”
- “sticky residue”
- “feels heavy”
Sources: lovi.care, perriconemd.com, dermstore.com, lookfantastic.com, ulta.com, lovelyskin.com, and more
Questions and answers
What makes Perricone MD Hyaluronic Intensive Hydrating Serum one of the best fits for mature skin?
This serum is one of the best fits for mature skin because it uses sodium hyaluronate and its crosspolymer to deliver deep hydration that plumps the skin and softens fine lines. It also includes peptides, niacinamide, and squalane to help smooth wrinkles, boost firmness, and keep the skin feeling soft and healthy.
Which ingredients make this serum a good fit for mature skin?
This serum is a great fit for mature skin because it contains acetyl tetrapeptide-11 and acetyl tetrapeptide-9 to boost collagen and firmness, alongside sodium hyaluronate for deep hydration that plumps away fine lines. Niacinamide and glycerin also help soothe the skin and keep it healthy.
What does Hyaluronic Acid do for mature skin?
Hyaluronic acid helps mature skin by deeply boosting moisture, improving elasticity, and smoothing the appearance of fine lines and wrinkles. Regular use keeps the skin looking plump and soft while supporting overall firmness and hydration.
Journal of Drugs in Dermatology, 2011Skin Research and Technology, 2024
What does Niacinamide do for mature skin?
Niacinamide helps mature skin by smoothing out fine lines and wrinkles, reducing dark spots, and improving overall skin elasticity. It is also very well tolerated and supports a strong skin barrier to keep skin looking healthy.
Where does this serum go in a skincare routine for mature skin?
This serum goes in the evening routine after cleansing and before moisturizing for simplicity and extra safety around sun exposure. It helps smooth fine lines and plump dry or normal mature skin with sodium hyaluronate, peptides, and niacinamide.
Journal of Drugs in Dermatology, 2023Dermatologic Therapy, 2022
Can I use this serum with retinol, and in what order?
Yes, you can use this serum with retinol, applying this hydrating treatment first before your retinol to help keep your skin calm and smooth. Using a barrier-supporting product like this alongside retinol is unlikely to cause irritation and may make your skin more comfortable with the treatment.
How often should I use this serum?
This serum is used in the evening as part of your routine for mature skin, applying it once a day for simplicity and extra safety around sun exposure. Daily application helps improve skin moisture, fine lines, and elasticity.
Journal of Cosmetic Dermatology, 2020Health Science Reports, 2021
Can this serum clog pores, cause breakouts or purging for mature skin?
This serum is unlikely to cause breakouts or clog pores because it has a light texture and lacks heavy ingredients that trap oil in the skin. Its gentle formulation makes it safe for daily use on mature skin without triggering irritation.
Can I use this serum around the eyes or on my body?
This serum is safe to use on the thin skin around your eyes and on your body to help smooth and hydrate mature skin. Regular application of these ingredients is unlikely to cause irritation while helping to plump fine lines and improve texture.
Is this serum fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone.
Dermatologic Therapy, 2022Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women.
Scientific Reports, 2024Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.
Journal of Drugs in Dermatology, 2011Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.
Clinical Oral Investigations, 2022Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.
BMC Oral Health, 2019Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts.
Molecules, 2025Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway.
Antioxidants, 2025Topical 2% N-acetyl glucosamine reduced facial hyperpigmentation in an 8-week split-face clinical test, with an even greater effect observed when combined with 4% niacinamide.
Journal of Cosmetic Dermatology, 2007N-acetyl-glucosamine-loaded nanostructured lipid carriers successfully delivered the hydrophilic agent through the skin and reduced melanin distribution in healthy volunteers.
Advanced Pharmaceutical Bulletin, 2016Topical cosmetic products containing hyaluronic acid, N-acetyl glucosamine, and gamma-amino butyric acid improved skin hydration by 24.28% to 33.60%, elasticity by 11.98%, and skin lightening by 5.26% over 2 months in 20 female participants.
Journal of Cosmetic and Laser Therapy, 2019
Ingredients
Water, Dimethicone, Butylene Glycol, Niacinamide, Acetyl Glucosamine, Squalane, Sodium Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Polysilicone-11, Cetearyl Olivate, Hdi Trimethylol Hexyllactone Crosspolymer, Polyisobutene, Sorbitan Olivate, Dimethyl Isosorbide, Polysorbate 20, 1,2-Hexanediol, Caprylyl Glycol, Dimethyl Mea, Hydroxyacetophenone, Citric Acid, Ceramide Np, Caprylyl Capryl Glucoside, Sorbitan Oleate, Sodium Gluconate, Spermidine, Silica, Sodium Acetylated Hyaluronate, Sodium Hyaluronate, Phenoxyethanol, Phytosphingosine, Sodium Hyaluronate Crosspolymer, Ethylhexylglycerin, Acetyl Tetrapeptide-11, Acetyl Tetrapeptide-9, Glycerin, Disodium Acetyl Glucosamine Phosphate, Sodium Glucuronate, Magnesium Sulfate
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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