MISSHA Time Revolution Night Repair Ampoule 5X for mature skin
Bifida Lysate Ferment
Niacinamide
Sodium Hyaluronate
Squalane
Extreme Biome
Average
- AverageNormal Skin Fit
- HighEffectiveness
- Low RiskSafety
Works for mature skin; other serums fit it better.
This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate suitability for normal skin, as Bifida Lysate Ferment and Glycerin provide barrier repair and humectant action, but it lacks sufficient ingredients specifically targeting normal skin concerns for optimal results.
- The formula provides general skincare benefits like hydration and soothing, which are supportive for wrinkles and fine lines due to the presence of Bifida Lysate Ferment and Adenosine.
- The safety profile is excellent, with no risks of irritation for your normal skin due to the absence of prohibited or harsh ingredients and the presence of soothing ingredients like Bifida Lysate Ferment and Niacinamide.
How to apply
- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
People Say
★4.7Overall rating based on 700+ reviewsUsers consistently praise this ampoule as a powerful anti-aging treatment that delivers deep hydration and a "glass skin" glow overnight, often comparing it favorably to the much more expensive Estée Lauder Advanced Night Repair. It is particularly effective for dry, mature, and sensitive skin types, helping to smooth rough texture and plump fine lines, though a minority of users with sensitivities to fermented ingredients or essential oils experienced irritation.
Highlights
Hydration and glow Mostly Mentioned
- “leaves my skin hydrated, soft, and glowy”
- “woke up with plump and glowy skin”
- “restores elasticity and radiance”
- “deeply moisturizes without being heavy”
Estée Lauder dupe Often Mentioned
- “best dupe for Estée Lauder's ANR”
- “works better than much more expensive serums”
- “fraction of the price of high-end brands”
- “similar texture to ANR but affordable”
Improves skin texture Often Mentioned
- “makes my skin so smooth”
- “softens rough texture overnight”
- “skin feels velvety soft”
- “helped evening out texture”
Fast absorption Sometimes Noted
- “absorbs pretty quickly”
- “non-sticky feel when massaged in”
- “layers nicely with other products”
- “lightweight and sinks in fast”
Scent irritation Sometimes Noted
- “smell is a bit strong”
- “contains essential oils like lavender and bergamot”
- “scent might be irritating for some”
- “wish it was fragrance-free”
Breakouts or irritation Rarely Noted
- “caused small bumps”
- “broke me out after a few days”
- “too sensitizing for my reactive skin”
- “reaction to the fermented ingredients”
Opaque packaging Rarely Noted
- “can't tell how much product is left”
- “bottle is too dark to see inside”
- “ran out unexpectedly”
- “hard to gauge remaining amount”
Sticky finish Rarely Noted
- “slightly sticky when it absorbs”
- “sits on top of my skin”
- “feels a bit tacky”
- “hair sticks to face after application”
Sources: lovi.care, iherb.com, misshaus.com, sokoglam.com, yesstyle.com, walmart.com, and more
Questions and answers
How well does MISSHA Night Repair Ampoule 5X work for mature skin?
This treatment works moderately well for mature skin, providing hydration and soothing benefits to help with fine lines. To give mature skin the best results, a product of this type needs potent antioxidants, hydrating components, skin-repairing ingredients, and ingredients specifically designed to improve skin elasticity.
International Journal of Cosmetic Science, 2018Journal of Cosmetic Dermatology, 2019
Which ingredients make this serum a good fit for mature skin?
Bifida Lysate Ferment and Adenosine make this serum a good fit for mature skin by helping smooth fine lines and wrinkles. A treatment of this type for mature skin needs potent antioxidants, hydrating components, skin-repairing ingredients, and peptides to improve elasticity and moisture retention.
International Journal of Cosmetic Science, 2018Journal of Cosmetic Dermatology, 2019
What does Bifida Ferment Lysate do for mature skin?
Bifida Ferment Lysate helps strengthen the skin barrier and calm irritation, which keeps mature skin feeling soft and comfortable. It also provides antioxidant support that may protect against everyday stress, though products for mature skin also need firming and smoothing ingredients like peptides and retinol.
Journal of Cosmetic Dermatology, 2023Experimental Dermatology, 2010
What does Niacinamide do for mature skin?
Niacinamide helps mature skin by smoothing out fine lines and wrinkles, reducing dark spots, and improving overall skin elasticity. It is also very well tolerated and supports a strong skin barrier to keep skin looking healthy.
Where does this serum go in a skincare routine for mature skin?
This treatment goes in the evening routine after cleansing and before moisturizing, which keeps things simple and safe around sun exposure. It is unlikely to irritate mature skin due to soothing ingredients like niacinamide, though mature skin also needs potent collagen-boosting ingredients and peptides for optimal firming results.
Can I use this serum with retinol, and in what order?
You can use this serum with retinol by applying the serum first to help hydrate and calm your skin, followed by your retinol. This product is unlikely to cause irritation because it lacks harsh ingredients and contains soothing components, though mature skin often needs additional targeted anti-aging ingredients for optimal results.
How often should I use this serum?
This serum fits into your evening routine as a treatment step. Mature skin needs products rich in antioxidants and collagen-boosting ingredients like peptides and retinoids to effectively target fine lines and firmness.
Clinical, Cosmetic and Investigational Dermatology, 2023Facial Plastic Surgery, 2014
Can this serum clog pores, cause breakouts or purging for mature skin?
This serum is unlikely to cause breakouts or irritation for mature skin due to the absence of harsh ingredients and the presence of soothing components like Niacinamide. To better support mature skin, products of this type also need potent antioxidants and collagen-boosting peptides.
Is this serum fragrance-free and alcohol-free?
It has no drying alcohol and contains fragrance (limonene).
What the research says
Adenosine-loaded dissolving microneedle patches showed similar or better efficacy on skin wrinkles, dermal density, elasticity, and hydration compared to adenosine cream in 22 female subjects.
International Journal of Cosmetic Science, 2018Horse oil-spread and adenosine-loaded dissolving microneedle patches significantly improved skin elasticity, hydration, dermal density, and wrinkles compared with adenosine-loaded dissolving microneedle patches in 20 women without causing adverse events.
Journal of Cosmetic Dermatology, 2019Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants.
International Journal of Molecular Sciences, 2026Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Topical application of Bifida Ferment Lysate strengthens the skin barrier function by upregulating barrier and antimicrobial peptide genes, exhibiting strong antioxidant properties, and decreasing inflammatory cytokine secretion in vitro.
Journal of Cosmetic Dermatology, 2023Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline.
Journal of Cosmetic and Laser Therapy, 2006Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.
Journal of Drugs in Dermatology, 2011Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.
Clinical Oral Investigations, 2022Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.
BMC Oral Health, 2019Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts.
Molecules, 2025Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway.
Antioxidants, 2025
Ingredients
Bifida Lysate Ferment, Butylene Glycol, Glycerin, Propanediol, Betaine, Water, Niacinamide, Pentylene Glycol, 1,2-Hexanediol, Diethoxyethyl Succinate, Chondrus Crispus Extract, Squalane, Panthenol, Polyglyceryl-10 Laurate, Saccharum Officinarum Extract, Hydrogenated Lecithin, Carbomer, Tromethamine, Xanthan Gum, Polyquaternium-51, Ethylhexylglycerin, Adenosine, Dextrin, Theobroma Cacao Extract, Bergamot Oil Fruit, Disodium Edta, Sodium Hyaluronate, Lactobacillus Ferment, Lactobacillus Lysate Ferment, Bifida Ferment Filtrate, Lactobacillus Acerola Cherry Ferment, Lactobacillus Punica Granatum Extract Fruit Ferment, Lactobacillus Soybean Extract Ferment, Lactococcus Ferment, Lactococcus Lysate Ferment, Leuconostoc Radish Root Ferment Filtrate, Pelargonium Graveolens Oil Flower, Beta Vulgaris Root Extract, Brassica Oleracea Capitata Leaf Extract, Daucus Carota Sativa Root Extract Carrot Root Extract, Solanum Melongena Fruit Extract, Blueberry Fruit Extract, Helianthus Annuus Seed Oil Sunflower Seed Oil, Citrus Aurantium Dulcis Peel Oil, Lavandula Angustifolia Oil Lavender Oil, Lupinus Albus Seed Extract, Aspergillus Ferment, Swiftlet Nest Extract, Anthemis Nobilis Oil Flower, Sandalwood Oil, Tocopherol, Ceramide Np, Cholesterol, Limonene
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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