Innisfree My Real Squeeze Mask for mature skin

How to apply

Questions and answers

What the research says

• Adenosine-loaded dissolving microneedle patches showed similar or better efficacy on skin wrinkles, dermal density, elasticity, and hydration compared to adenosine cream in 22 female subjects.

  International Journal of Cosmetic Science, 2018

• Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

  Journal of Cosmetic Dermatology, 2021

• Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women.

  Scientific Reports, 2024

• Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements.

  Indian Journal of Pharmaceutical Sciences, 2016

• Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components.

  Molecules, 2023

• A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo.

  Clinical Pharmacology, 2018

• Topical aloe vera gel significantly accelerated split-thickness skin graft donor-site healing compared to placebo in 12 patients, but showed no significant difference in pain relief.

  Plastic and Reconstructive Surgery, 2018

• Topical application of Aloe vera cream reduced postoperative pain at rest and during defecation, accelerated wound healing at two weeks, and decreased analgesic requirements in patients after open hemorrhoidectomy compared to placebo.

  Journal of Alternative and Complementary Medicine, 2010

• Topical green tea extract significantly improved clinical symptoms, tear breakup times, and meibomian gland health compared to standard treatment in patients with dry eye and Meibomian Gland Dysfunction.

  Journal of Clinical and Diagnostic Research, 2017

• Topical low-dose green tea extract reduces UVB-induced p53 expression and apoptosis in human skin keratinocytes compared to placebo.

  Experimental Dermatology, 2009

• An anti-acne hydrogel containing Aloe barbadensis, Garcinia mangostana, and Camellia sinensis extracts showed superior antiacne and antiblotch activities compared to 1% clindamycin gel in sixty subjects with mild-moderate acne.

  Clinical, Cosmetic and Investigational Dermatology, 2019

• A combination cream of stimu-tex AS and saccharide isomerate reduced erythema, increased skin capacitance, and reduced transepidermal water loss compared to placebo in 20 subjects after fractional CO2 laser procedure without causing serious adverse events.

  Lasers in Medical Science, 2025

• A skin barrier restoring cream with shea butter, silkflo, and vitamin E increased type I procollagen synthesis, enhanced antioxidant enzyme activity, decreased reactive oxygen species generation, and promoted hyaluronic acid production in H2O2-stimulated human keratinocyte cells compared to untreated cells.

  International Journal of Cosmetic Science, 2025

• Topical lycopene-based emulgel significantly enhanced skin hydration and elasticity while reducing erythema, melanin, and sebum contents in human volunteers compared to a placebo formulation over 12 weeks.

  European Journal of Pharmaceutics and Biopharmaceutics, 2022

• Cosmetic formulations containing lycopene and melatonin showed significant differences in skin sebum content, hydration, elasticity, erythema index, and melanin index compared to control in 36 healthy women.

  Skin Pharmacology and Physiology, 2020

• Topical delivery of lycopene via MG- and TG-containing microemulsions significantly increased stratum corneum and viable skin layer penetration compared to a control solution, with the MG-containing microemulsion also increasing skin antioxidant activity by 10-fold.

  Journal of Pharmaceutical Sciences, 2010

• Topical sulforaphane treatment reduced mottled skin pigmentation in humans and UV-induced pigmentation in wild-type mice through NRF2 and keratinocyte-specific IL-6Rα signaling.

  JCI Insight, 2020

• Topical application of sulforaphane-rich broccoli sprout extracts reduced UVR-induced erythema by a mean of 37.7% in six human subjects.

  Proceedings of the National Academy of Sciences of the United States of America, 2007

• Pre-treatment with sulforaphane and phenylethyl isothiocyanate significantly counteracted UVR-induced increases in apoptosis and decreases in catalase in human skin by inducing Nrf2-dependent antioxidant pathways.

  Pharmacological Research, 2013

Ingredients

1,2-Hexanediol, Citrus Unshiu Peel Extract, Glycerin, Butylene Glycol, Camellia Japonica Leaf Extract, Camellia Sinensis Leaf Extract, Caprylic Capric Triglyceride, Carbomer, Centella Asiatica Extract, Cetyl Ethylhexanoate, Chamomilla Recutita Flower Extract Matricaria Flower Extract, Dimethicone, Disodium Edta, Ethylhexylglycerin, Glyceryl Caprylate, Glyceryl Stearate, Opuntia Coccinellifera Fruit Extract, Orchid Extract, Paeonia Suffruticosa Root Extract, Peg-100 Stearate, Polyglyceryl-3 Methylglucose Distearate, Sodium Hyaluronate, Tromethamine, Water, Xanthan Gum, Aloe Barbadensis Leaf Juice, Avena Sativa Kernel Extract Oat Kernel Extract, Coconut Fruit Juice, Dipotassium Glycyrrhizate, Brassica Oleracea Italica Extract, Panthenol, Honey Extract, Niacinamide, Adenosine

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.