Dear, Klairs Midnight Blue Youth Activating Drop for sensitive skin
Rh-Oligopeptide-1
Sh-Polypeptide-1
Blueberry Fruit Extract
GuaiazuleneAverage
- HighNormal Skin Fit
- AverageEffectiveness
- HighSafety
Works for sensitive skin; other serums fit it better.
This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate rejuvenation for normal skin, as Sh-Oligopeptide-1 and Sh-Polypeptide-1 stimulate collagen and boost ECM synthesis, but lacks ingredients to specifically target your redness and irritation concerns.
- Guaiazulene provides some soothing benefits, which is helpful for your sensitive skin, but the overall formulation does not prioritize anti-inflammatory action.
- The product is safe for your sensitive skin due to the absence of harsh ingredients and the inclusion of soothing components.
How to apply
- Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
- Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
- Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
- Always do a patch test before your first use and avoid getting the serum too close to your eyes .
People Say
★4.4Overall rating based on 1.5k+ reviewsBased on a very large amount of data, this product is widely praised as a lightweight, watery anti-aging serum that absorbs instantly and is exceptionally gentle, making it a favorite for oily and sensitive skin types. Many users report smoother skin texture, reduced redness, and a plump feel. Some find the 20ml bottle too small for the price and note that its preventative anti-aging effects take time to become visible.
Highlights
Rapid absorption Mostly Mentioned
- “absorbs like a dream”
- “drinks it up instantly”
- “leaves no residue”
- “disappears into skin”
Small volume/price Mostly Mentioned
- “finished in 3 weeks”
- “wish it was bigger”
- “pricey for the size”
- “tiny bottle”
Gentle formula Often Mentioned
- “didn't break me out”
- “no stinging”
- “safe for reactive skin”
Soothing & calming Often Mentioned
- “calms my redness”
- “soothing on sensitive skin”
- “helps with irritation”
- “great for post-sun”
Improves texture Sometimes Noted
- “skin feels softer”
- “noticed smoother texture”
- “woke up glowing”
- “pores look smaller”
Slow visible results Sometimes Noted
- “didn't see wrinkle reduction”
- “takes months to work”
- “more preventative than corrective”
- “no dramatic difference”
Watery consistency Sometimes Noted
- “runs off my hand”
- “hard to control dropper”
- “too thin like water”
- “spills easily”
Not moisturizing Rarely Noted
- “need moisturizer on top”
- “feels like just water”
- “not enough hydration”
- “must layer quickly”
Sources: lovi.care, iherb.com, sokoglam.com, wishtrend.com, yesstyle.com, reddit.com, and more
Questions and answers
How well does the Midnight Blue Youth Activating Drop work for sensitive skin?
Dear, Klairs Midnight Blue Youth Activating Drop works moderately well for sensitive skin, offering some soothing benefits from guaiazulene while lacking targeted ingredients for redness and irritation. A product of this type needs powerful antioxidants, hydrating components, and specialized skin-repairing ingredients to properly calm and protect this skin.
Which ingredients make this treatment a good fit for sensitive skin?
Guaiazulene helps soothe sensitive skin, while Sh-Oligopeptide-1 and Sh-Polypeptide-1 support skin repair without causing irritation. However, a treatment for this skin needs dedicated anti-inflammatory ingredients like niacinamide or snail secretion filtrate to properly target redness and irritation.
What does EGF do for sensitive skin?
EGF helps calm sensitive skin by supporting barrier recovery and reducing moisture loss after irritation. It also helps protect skin cells from environmental damage and lowers inflammation to keep your face feeling soft and smooth.
Where does this treatment go in a skincare routine for sensitive skin?
This treatment goes in the evening routine after your soothing toner and before your moisturizer. It is safe for sensitive skin because it lacks harsh ingredients and includes soothing components, though a product for this skin also needs ingredients to specifically target redness and irritation.
Can I use this treatment with retinol, and in what order?
You can use this treatment alongside retinol by applying the treatment first and following with your retinol after it absorbs. This product is generally safe for your skin because it lacks harsh ingredients and includes soothing components.
How often should I use this treatment?
You can use this treatment in the evening as part of your routine. This product works for your sensitive skin, though it is an average fit because it lacks ingredients to specifically target your redness and irritation. Sensitive skin needs a product of this type that also includes extra soothing components and anti-inflammatory ingredients to calm irritation.
Can this treatment clog pores, cause breakouts or purging for sensitive skin?
This treatment is unlikely to clog pores or cause breakouts on sensitive skin due to the absence of heavy or harsh ingredients in its formula. However, because it does not trigger cell turnover like retinoids do, it will not cause purging either.
Is this treatment fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
Bovine basic fibroblast growth factor combined with ultrapulsed fractional CO2 laser increased the overall response rate, reduced ECCA scores, scar base depth, skin pore value, texture value, transepidermal water loss, redness duration, scabbing duration, erythema duration, and adverse reactions, while increasing skin water and epidermal oil content in patients with acne scars compared to ultrapulsed fractional CO2 laser therapy alone.
Clinical, Cosmetic and Investigational Dermatology, 2023Topical epidermal growth factor combined with silver sulfadiazine accelerated the rate of epidermal regeneration and significantly decreased healing time by approximately 1 to 1.5 days across all stages of healing in skin-graft-donor sites of 12 patients compared to silver sulfadiazine alone.
The New England Journal of Medicine, 1989Topical recombinant human epidermal growth factor combined with ablative fractional carbon dioxide laser significantly improved striae surface texture and showed significantly greater participant satisfaction regarding marked improvement compared to ablative fractional carbon dioxide laser combined with Aloe vera gel in patients with striae alba.
Lasers in Surgery and Medicine, 2020Topical EGF combined with fractional CO2 laser significantly improves the clinical appearance of atrophic acne scars and decreases skin pigmentation compared to fractional CO2 laser alone in patients with atrophic acne scars.
The Journal of Clinical and Aesthetic Dermatology, 2022Topical application of PTD-EGF and FGF1 increased cell proliferation and collagen accumulation while protecting against UV-induced damage and improving wrinkle parameters in human skin.
Journal of Cosmetic Dermatology, 2013Basic fibroblast growth factor-loaded human serum albumin nanoparticles enhanced the proliferation and migration of human dermal fibroblasts, down-regulated myofibroblast-related genes, and accelerated wound healing with enhanced angiogenesis in vivo compared to unstable native forms.
Journal of Nanobiotechnology, 2023Topical application of basic fibroblast growth factor decreases elevated transepidermal water loss and increases Ki67 expression in keratinocytes following mechanical scratching in a mouse model.
Skin Pharmacology and Physiology, 2013Applying a topical product containing blueberry extract and Pro-xylane following micro-focused ultrasound significantly improved global aesthetic improvement, skin elasticity, and fine lines compared to standard moisturizer in 50 patients.
Journal of Cosmetic Dermatology, 2025Topical usage of blueberries may prevent skin damage from environmental stressors by inducing an active skin response against noxious effects.
Antioxidants, 2023Pretreatment with blueberry extracts prevented ozone-induced ROS production, NLRP1-ASC scaffold formation, and CASP1 and IL-18 transcripts across 2D, 3D, and human skin explant models.
Oxidative Medicine and Cellular Longevity, 2020
Why other serums fit sensitive skin better
Topical application of TAT-SOD significantly suppresses UVB-induced erythema formation, blood flow rise, and apoptotic sunburn cell formation in human volunteers compared to a vehicle control.
European Journal of Pharmaceutics and Biopharmaceutics, 2016
Ingredients
Water, Butylene Glycol, Sh-Oligopeptide-1, Sh-Polypeptide-1, Blueberry Fruit Extract, Lecithin, Sorbitan Sesquioleate, 1,2-Hexanediol, Caprylyl Glycol, Peg-60 Hydrogenated Castor Oil, Glycerin, Chlorphenesin, Guaiazulene, Ethylhexylglycerin, Adenosine
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
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