Dear, Klairs Midnight Blue Youth Activating Drop for combination skin
Rh-Oligopeptide-1
Sh-Polypeptide-1
Blueberry Fruit Extract
GuaiazuleneHigh
- HighCombination Skin Fit
- HighEffectiveness
- ExcellentSafety
A great choice for combination skin; a few serums fit it even better.
This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- This product offers excellent skin rejuvenation for your combination skin, as Sh-Oligopeptide-1 and Sh-Polypeptide-1 promote collagen stimulation and boost extracellular matrix synthesis to minimize fine lines and wrinkles.
- Blueberry fruit extract and adenosine further enhance skin regeneration and improve texture, addressing your concerns with oily shine.
- The formula is safe for your skin, with Guaiazulene providing soothing benefits and no harsh ingredients present.
How to apply
- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
People Say
★4.4Overall rating based on 1.5k+ reviewsBased on a very large amount of data, this product is widely praised as a lightweight, watery anti-aging serum that absorbs instantly and is exceptionally gentle, making it a favorite for oily and sensitive skin types. Many users report smoother skin texture, reduced redness, and a plump feel. Some find the 20ml bottle too small for the price and note that its preventative anti-aging effects take time to become visible.
Highlights
Rapid absorption Mostly Mentioned
- “absorbs like a dream”
- “drinks it up instantly”
- “leaves no residue”
- “disappears into skin”
Small volume/price Mostly Mentioned
- “finished in 3 weeks”
- “wish it was bigger”
- “pricey for the size”
- “tiny bottle”
Gentle formula Often Mentioned
- “didn't break me out”
- “no stinging”
- “safe for reactive skin”
Soothing & calming Often Mentioned
- “calms my redness”
- “soothing on sensitive skin”
- “helps with irritation”
- “great for post-sun”
Improves texture Sometimes Noted
- “skin feels softer”
- “noticed smoother texture”
- “woke up glowing”
- “pores look smaller”
Slow visible results Sometimes Noted
- “didn't see wrinkle reduction”
- “takes months to work”
- “more preventative than corrective”
- “no dramatic difference”
Watery consistency Sometimes Noted
- “runs off my hand”
- “hard to control dropper”
- “too thin like water”
- “spills easily”
Not moisturizing Rarely Noted
- “need moisturizer on top”
- “feels like just water”
- “not enough hydration”
- “must layer quickly”
Sources: lovi.care, iherb.com, sokoglam.com, wishtrend.com, yesstyle.com, reddit.com, and more
Questions and answers
What makes Dear, Klairs Midnight Blue Youth Activating Drop a great fit for combination skin?
This treatment is a great fit for your combination skin because peptides help boost collagen to smooth fine lines, while blueberry extract and adenosine improve your texture and help manage oily shine. It also features soothing ingredients like Guaiazulene to help keep your skin calm and safe from irritation.
Which ingredients make this serum a good fit for combination skin?
Sh-Oligopeptide-1, Sh-Polypeptide-1, and blueberry fruit extract make this serum a great fit by smoothing fine lines and managing oily shine on combination skin. Guaiazulene also helps keep your skin calm and is very safe to use.
What does EGF do for combination skin?
EGF helps support cell turnover and collagen production, which may improve firmness and keep combination skin looking smooth and even. For the best results on combination skin, this ingredient works well alongside hydrating ingredients like hyaluronic acid to balance oilier and dry areas.
Journal of Drugs in Dermatology, 2019Cell Proliferation, 2022
Where does this serum go in a skincare routine for combination skin?
This treatment goes in your evening routine after your cleansing toner and before your moisturizer. Putting it in the evening keeps things simple and provides extra safety around sun exposure.
Can I use this serum with retinol, and in what order?
Yes, you can use this serum with retinol by applying the serum first to let it absorb, followed by your retinol. This approach helps keep your combination skin smooth and calm while minimizing fine lines.
How often should I use this serum?
This treatment is meant for your evening routine, where it helps smooth fine lines and improve texture on combination skin. It is safe for regular use as part of your nightly routine, while providing soothing benefits through ingredients like Guaiazulene.
Can this serum clog pores, cause breakouts or purging for combination skin?
This serum is unlikely to clog pores or cause breakouts on combination skin. Its lightweight formula is safe and contains soothing ingredients that help calm the skin without heavy, pore-blocking oils.
Is this serum fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
Bovine basic fibroblast growth factor combined with ultrapulsed fractional CO2 laser increased the overall response rate, reduced ECCA scores, scar base depth, skin pore value, texture value, transepidermal water loss, redness duration, scabbing duration, erythema duration, and adverse reactions, while increasing skin water and epidermal oil content in patients with acne scars compared to ultrapulsed fractional CO2 laser therapy alone.
Clinical, Cosmetic and Investigational Dermatology, 2023Topical epidermal growth factor combined with silver sulfadiazine accelerated the rate of epidermal regeneration and significantly decreased healing time by approximately 1 to 1.5 days across all stages of healing in skin-graft-donor sites of 12 patients compared to silver sulfadiazine alone.
The New England Journal of Medicine, 1989Topical recombinant human epidermal growth factor combined with ablative fractional carbon dioxide laser significantly improved striae surface texture and showed significantly greater participant satisfaction regarding marked improvement compared to ablative fractional carbon dioxide laser combined with Aloe vera gel in patients with striae alba.
Lasers in Surgery and Medicine, 2020Topical EGF combined with fractional CO2 laser significantly improves the clinical appearance of atrophic acne scars and decreases skin pigmentation compared to fractional CO2 laser alone in patients with atrophic acne scars.
The Journal of Clinical and Aesthetic Dermatology, 2022Topical application of PTD-EGF and FGF1 increased cell proliferation and collagen accumulation while protecting against UV-induced damage and improving wrinkle parameters in human skin.
Journal of Cosmetic Dermatology, 2013Basic fibroblast growth factor-loaded human serum albumin nanoparticles enhanced the proliferation and migration of human dermal fibroblasts, down-regulated myofibroblast-related genes, and accelerated wound healing with enhanced angiogenesis in vivo compared to unstable native forms.
Journal of Nanobiotechnology, 2023Topical application of basic fibroblast growth factor decreases elevated transepidermal water loss and increases Ki67 expression in keratinocytes following mechanical scratching in a mouse model.
Skin Pharmacology and Physiology, 2013Applying a topical product containing blueberry extract and Pro-xylane following micro-focused ultrasound significantly improved global aesthetic improvement, skin elasticity, and fine lines compared to standard moisturizer in 50 patients.
Journal of Cosmetic Dermatology, 2025Topical usage of blueberries may prevent skin damage from environmental stressors by inducing an active skin response against noxious effects.
Antioxidants, 2023Pretreatment with blueberry extracts prevented ozone-induced ROS production, NLRP1-ASC scaffold formation, and CASP1 and IL-18 transcripts across 2D, 3D, and human skin explant models.
Oxidative Medicine and Cellular Longevity, 2020
Ingredients
Water, Butylene Glycol, Sh-Oligopeptide-1, Sh-Polypeptide-1, Blueberry Fruit Extract, Lecithin, Sorbitan Sesquioleate, 1,2-Hexanediol, Caprylyl Glycol, Peg-60 Hydrogenated Castor Oil, Glycerin, Chlorphenesin, Guaiazulene, Ethylhexylglycerin, Adenosine
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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