Bolden Dark Spot Fix for mature skin

How to apply

Questions and answers

What the research says

• Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer.

  The British Journal of Dermatology, 2002

• Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

  Journal of Cosmetic Dermatology, 2021

• Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women.

  Scientific Reports, 2024

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

  The Journal of Investigative Dermatology, 2008

• Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

  Dermatologic Surgery, 2005

• Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline.

  Journal of Cosmetic and Laser Therapy, 2006

• A non-hydroquinone topical formulation (SKNB19) improved hyperpigmentation by 28.5% in patient self-assessment and 27% in independent reviewer assessment compared with 4% hydroquinone in 18 adult subjects, while showing significantly less irritation and better tolerability.

  Journal of Cosmetic Science, 2020

• Encapsulation of alpha arbutin in an optimized ethosomal gel significantly improved skin melanin reduction, moisture content, and elasticity in human volunteers compared to conventional formulations.

  Heliyon, 2023

• Combining a home-based radiofrequency device and arbutin cream reduced mMASI scores by 25.6% and melanin index by 22.8% at 8 weeks compared to baseline in 38 participants.

  Journal of Cosmetic Dermatology, 2025

• A topical formulation containing kojic acid, emblica extract, and glycolic acid demonstrated efficacy parity compared with hydroquinone 4% in multiethnic participants with mild to moderate facial dyschromia.

  Cutis, 2010

• A nanoemulsion containing 1 mg/mL kojic dipalmitate and 5% rosehip oil demonstrated high incorporation efficiency, suitable physicochemical stability, antioxidant and depigmenting efficacy close to 1 mM ascorbic acid, and no cytotoxicity at concentrations from 0.06% to 1% in vitro.

  Pharmaceutics, 2023

• Topical application of iron chelators kojic acid and deferiprone significantly accelerated wound healing in rats compared to control groups, with deferiprone showing superior efficacy due to higher antioxidant and iron chelation abilities.

  International Wound Journal, 2013

• Azelaic acid nanocrystal hydrogel 10% achieved a higher success rate and greater lesion reduction than azelaic acid cream 20% in patients with mild to moderate facial acne.

  Pharmaceutics, 2021

• Application of 15% azelaic acid gel significantly reduced post-inflammatory erythema and hyperpigmentation, decreased hemoglobin and melanin content, improved quality of life, and contributed to acne improvement in patients with mild to moderate acne compared to placebo.

  Dermatology and Therapy, 2024

• Topical application of a dermocosmetic containing Myrtus communis extract and azelaic acid reduced acne relapses and helped maintain remission compared to a light moisturizing cream in adult females in the acne maintenance phase over 16 weeks.

  Journal of the European Academy of Dermatology and Venereology, 2023

Why other serums fit mature skin better

• Topical application of retinol and retinoic acid both increased epidermal thickness and upregulated collagen genes and proteins in human skin, with retinol producing similar histological and molecular changes to retinoic acid alongside a significant reduction in facial wrinkles after 12 weeks.

  Journal of Cosmetic Dermatology, 2016

• A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers.

  Journal of Cosmetic Dermatology, 2020

Ingredients

Water, Caprylic Capric Triglyceride, Glycerin, Niacinamide, Tranexamic Acid, Glyceryl Stearate, Allantoin, Behynyl Alcohol, Squalane, Ceteareth-20, Phytic Acid, Butyrospermum Parkii Butter Shea Butter, Ceteareth-12, Cetearyl Alcohol, Cetyl Palmitate, Sclerotium Gum, Sodium Lauroyl Glutamate, Alpha-Arbutin, Glutathione, Kojic Acid, Bisabolol, Azelaic Acid, Tetrapeptide-30

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.