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BIOEFFECT EGF Power Serum for mature skin

High

  • HighNormal Skin Fit
  • HighEffectiveness
  • HighSafety

A great choice for mature skin; a few serums fit it even better.

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.

Page built Nov 8, 2026How the Fit score works

Lovi Assistant explains

  • Offers high suitability for normal skin, as sodium hyaluronate and glycerin provide adequate hydration without overwhelming your skin.
  • The presence of rh-oligopeptide-1 barley sh-oligopeptide-1 and kgf barley sh-polypeptide-3 promotes collagen production, effectively addressing your concerns with wrinkles and fine lines.
  • The safety profile is excellent, with no risks of irritation due to the absence of prohibited or harsh ingredients.

How to apply

  • Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
  • Apply this serum after your toner and before your moisturizer.
  • Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
  • You can apply the serum on dry skin for the best results against fine lines.
  • Always do a patch test before your first use and avoid the sensitive eye area.

People Say

★4.7Overall rating based on 100+ reviews

This serum is highly effective for mature, dry, and aging skin, with users frequently reporting improvements in texture, firmness, and radiance. Based on limited data, the product is praised for visibly reducing fine lines and hyperpigmentation, leaving the complexion plumper and more even-toned. Some users note a tacky feel after application and that results require patience, while the high price point is a common concern.

Highlights

  • Improves skin texture Mostly Mentioned
    • “Skin feels smoother”
    • “texture has improved”
    • “skin is plumper”
  • High price point Mostly Mentioned
    • “Very pricey”
    • “could not have afforded”
    • “worth every penny but expensive”
  • Boosts skin radiance Often Mentioned
    • “Skin looks glowing”
    • “complexion more radiant”
    • “beaming skin”
  • Reduces fine lines Often Mentioned
    • “Laugh lines less obvious”
    • “wrinkles less visible”
    • “targets fine lines”
  • Deeply hydrating Sometimes Noted
    • “Instant hydration boost”
    • “sealing in moisture”
    • “great for dehydrated skin”
  • Gentle formula Sometimes Noted
    • “Great on sensitive skin”
    • “no breakouts”
    • “non-irritating”
  • Requires patience Sometimes Noted
    • “Takes weeks to notice”
    • “not instant results”
    • “cumulative improvements”
  • Tacky skin feel Sometimes Noted
    • “Sticky for 30 mins”
    • “tacky feel after application”
  • Limited care feeling Rarely Noted
    • “Doesn't feel 'creamed'”
    • “need extra moisturizer”
    • “not enough for some”

Sources: lovi.care, bioeffect.com, dermstore.com, whowhatwear.com, joannaczech.com, katiesnooks.com, and more

Questions and answers

What makes BIOEFFECT EGF Power Serum a great fit for mature skin?

This serum is a great fit for mature skin because its ingredients promote collagen production to help smooth out wrinkles and fine lines, while glycerin and sodium hyaluronate keep your skin well-hydrated. It also has a very safe formula with no harsh ingredients, meaning it is unlikely to cause irritation.

Clinical, Cosmetic and Investigational Dermatology, 2017

Which ingredients make this serum a good fit for mature skin?

Rh-oligopeptide-1 and keratinocyte growth factor help promote collagen production to smooth out wrinkles and fine lines on mature skin. Sodium hyaluronate and glycerin also provide deep hydration, while the gentle formula keeps irritation risks very low.

Clinical, Cosmetic and Investigational Dermatology, 2017Dermatologic Therapy, 2022

What does EGF do for mature skin?

For mature skin, epidermal growth factor helps smooth fine lines, improve firmness, and support a more youthful look by encouraging skin renewal. It works best when paired with ingredients that deeply hydrate and protect against moisture loss to keep the skin feeling soft and smooth.

Journal of Cosmetic Dermatology, 2013International Journal of Molecular Medicine, 2017

What does Hyaluronic Acid do for mature skin?

Hyaluronic acid helps mature skin by deeply boosting moisture, improving elasticity, and smoothing the appearance of fine lines and wrinkles. Regular use keeps the skin looking plump and soft while supporting overall firmness and hydration.

Journal of Drugs in Dermatology, 2011Skin Research and Technology, 2024

Where does this serum go in a skincare routine for mature skin?

This treatment goes in your evening routine after cleansing and before moisturizing, which keeps things simple and safe around sun exposure. It is a great fit for mature skin because it promotes collagen production to smooth fine lines and wrinkles while keeping your skin well hydrated.

Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first and following it with your retinol product, or by using them on alternate nights to keep your skin calm. Because this formula contains gentle hydrating ingredients and lacks harsh additives, it is unlikely to cause irritation when paired thoughtfully with active routines.

How often should I use this serum?

You can use this serum in the evening as part of your routine. It is a great fit for mature skin, providing hydration and helping with fine lines and wrinkles safely.

Facial Plastic Surgery, 2014Clinical, Cosmetic and Investigational Dermatology, 2017

Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to clog pores or cause breakouts for mature skin because it has an excellent safety profile without harsh or heavy ingredients. Sodium hyaluronate and glycerin help keep skin hydrated without overwhelming it.

Clinical, Cosmetic and Investigational Dermatology, 2017

Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

What the research says

  • A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

    Clinical, Cosmetic and Investigational Dermatology, 2017
  • Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone.

    Dermatologic Therapy, 2022
  • Topical epidermal growth factor combined with silver sulfadiazine accelerated the rate of epidermal regeneration and significantly decreased healing time by approximately 1 to 1.5 days across all stages of healing in skin-graft-donor sites of 12 patients compared to silver sulfadiazine alone.

    The New England Journal of Medicine, 1989
  • Topical recombinant human epidermal growth factor combined with ablative fractional carbon dioxide laser significantly improved striae surface texture and showed significantly greater participant satisfaction regarding marked improvement compared to ablative fractional carbon dioxide laser combined with Aloe vera gel in patients with striae alba.

    Lasers in Surgery and Medicine, 2020
  • Topical EGF combined with fractional CO2 laser significantly improves the clinical appearance of atrophic acne scars and decreases skin pigmentation compared to fractional CO2 laser alone in patients with atrophic acne scars.

    The Journal of Clinical and Aesthetic Dermatology, 2022
  • Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

    Journal of Drugs in Dermatology, 2011
  • Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

    Clinical Oral Investigations, 2022
  • Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

    BMC Oral Health, 2019
  • Topical 2% N-acetyl glucosamine reduced facial hyperpigmentation in an 8-week split-face clinical test, with an even greater effect observed when combined with 4% niacinamide.

    Journal of Cosmetic Dermatology, 2007
  • N-acetyl-glucosamine-loaded nanostructured lipid carriers successfully delivered the hydrophilic agent through the skin and reduced melanin distribution in healthy volunteers.

    Advanced Pharmaceutical Bulletin, 2016
  • Topical cosmetic products containing hyaluronic acid, N-acetyl glucosamine, and gamma-amino butyric acid improved skin hydration by 24.28% to 33.60%, elasticity by 11.98%, and skin lightening by 5.26% over 2 months in 20 female participants.

    Journal of Cosmetic and Laser Therapy, 2019
  • The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.

    Journal of Cosmetic Dermatology, 2020
  • Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.

    International Journal of Cosmetic Science, 2001
  • Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects.

    Journal of Drugs in Dermatology, 2012

Ingredients

Glycerin, Water, Sodium Citrate, Acetyl Glucosamine Nag, Isopentyldiol, Phenoxyethanol, Sodium Chloride, Sodium Hyaluronate, Citric Acid, Hordeum Vulgare Seed Extract, Rh-Oligopeptide-1 Barley Sh-Oligopeptide-1, Kgf Barley Sh-Polypeptide-3

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

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