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Hexapeptide and vitamin A

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

Hexapeptide and vitamin A: keep them apart

Keep them apart

Use them at different times of day, applying vitamin A at night and hexapeptide in the morning, to prevent skin irritation. Both ingredients work hard to smooth the skin, which can sometimes be too much for it to handle all at once. You can make it work by using a gentler strength or waiting longer between applications.

Hexapeptide products

Vitamin A products

Questions and answers

Can you use hexapeptide and vitamin A together?

Keep hexapeptide and vitamin A apart because combining strong retinoids with peptides may increase skin irritation. Instead, alternate your usage by applying the vitamin A product in the evening and the peptides in the morning.

Which goes first, hexapeptide or vitamin A?

Keep hexapeptide and vitamin A apart by using them at different times of day, applying the vitamin A retinoid in the evening and the hexapeptide in the morning. Combining them together may increase skin irritation.

Are hexapeptide and vitamin A good for sensitive skin?

Hexapeptide and vitamin A should be kept apart in a sensitive skin routine because combining them may increase irritation. Try using your retinoid in the evening and peptides in the morning.

Research on hexapeptide and vitamin A

Behind this pairing advice

Lovi checks every pairing with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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