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Hexapeptide and baking soda

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

Hexapeptide and baking soda: keep them apart

Keep them apart

Use them at different times of day by applying your peptide product first, because baking soda stops peptides from working properly. Baking soda is too harsh and ruins the firming benefits of the hexapeptide, leaving your skin without the anti-aging results you want. You can separate them by using baking soda in the morning and peptides at night, or switch to a gentler cleanser.

Hexapeptide products

Baking soda products

Questions and answers

Can you use hexapeptide and baking soda together?

No, you should keep hexapeptide and baking soda apart because alkaline environments cause peptides to lose stability and activity. It is best to use them in separate routines.

Which goes first, hexapeptide or baking soda?

Keep hexapeptide and baking soda apart in your routine, as the high alkalinity of baking soda may reduce peptide stability and activity.

Are hexapeptide and baking soda good for sensitive skin?

Keep hexapeptide and baking soda apart in your routine, because baking soda is too alkaline and causes peptides to lose stability and activity. Lovi gives this combination an average fit for your skin.

Research on hexapeptide and baking soda

Behind this pairing advice

Lovi checks every pairing with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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