Sulwhasoo The Ultimate S Cream for mature skin

How to apply

Questions and answers

What the research says

• Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group.

  American Journal of Clinical Dermatology, 2013

• Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days.

  Annals of Dermatology, 2019

• Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear.

  Journal of Cosmetic Dermatology, 2017

• A mixture of Panax ginseng and Crataegus pinnatifida prevented skin aging by improving procollagen type I expression, diminishing matrix metalloproteinase-1 secretion, reducing skin roughness and photodamage scores, and decreasing loss of skin moisture in human dermal fibroblasts and healthy human skin.

  Journal of Ginseng Research, 2017

• Panax ginseng root extract induced Type I procollagen synthesis and COL1A2 promoter activity through Smad2 phosphorylation in human dermal fibroblast cells.

  Journal of Ethnopharmacology, 2007

• Enzyme-modified ginseng extract cream significantly reduced the global photo-damage score and various roughness measures including total roughness, smoothness depth, and arithmetic roughness average compared to placebo in 23 human subjects.

  Rejuvenation Research, 2015

• A red ginseng hydrogel formulation with 1,2-hexanediol promoted selective growth of Staphylococcus epidermidis and decreased Cutibacterium acnes in 20 female subjects.

  Journal of Ginseng Research, 2022

• A 1% fermented black ginseng cream significantly reduced eye wrinkles and brightened skin color in twenty-three human subjects compared to control cream and baseline.

  Journal of Toxicology and Environmental Health. Part A, 2020

• A combination cream of stimu-tex AS and saccharide isomerate reduced erythema, increased skin capacitance, and reduced transepidermal water loss compared to placebo in 20 subjects after fractional CO2 laser procedure without causing serious adverse events.

  Lasers in Medical Science, 2025

• A skin barrier restoring cream with shea butter, silkflo, and vitamin E increased type I procollagen synthesis, enhanced antioxidant enzyme activity, decreased reactive oxygen species generation, and promoted hyaluronic acid production in H2O2-stimulated human keratinocyte cells compared to untreated cells.

  International Journal of Cosmetic Science, 2025

• Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts.

  Molecules, 2025

• Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway.

  Antioxidants, 2025

• Daily topical acetyl hexapeptide-8 showed a trend toward a longer time until return to baseline Jankovic Blepharospasm Rating Scale scores compared to placebo (3.7 months vs. 3.0 months) in 24 patients with blepharospasm receiving botulinum toxin therapy.

  European Journal of Neurology, 2013

• Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects.

  Journal of Cosmetic and Laser Therapy, 2013

• Dissolving microneedles loaded with 3-O-ethyl ascorbic acid and acetyl hexapeptide-8 achieved higher cumulative transdermal delivery than aqueous solutions and significantly reduced photoaging signs while restoring oxidative balance in a UV/D-galactose-induced mouse model.

  International Journal of Biological Macromolecules, 2026

• Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls.

  Journal of Cosmetic Dermatology, 2025

• Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate.

  Contemporary Clinical Trials Communications, 2021

• Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin.

  Journal of Cosmetic Dermatology, 2024

Ingredients

Water, Butylene Glycol, Triethylhexanoin, Glycerin, Dimethicone, Squalane, Pentaerythrityl Tetraethylhexanoate, Cetyl Ethylhexanoate, Polyglyceryl-3 Methylglucose Distearate, Trisiloxane, 2-Hexanediol, Diisostearyl Malate, Hydrogenated Polyisobutene, Glyceryl Stearate, Peg-100 Stearate, Cetearyl Alcohol, Pentaerythrityl Distearate, Behenyl Alcohol, Polyglycerin-3, Butyrospermum Parkii Butter Shea Butter, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Parfum, Ammonium Acryloyldimethyltaurate Vp Copolymer, Hydroxypropyl Phosphate Starch, Hydrolyzed Ginseng Saponins Enzyme-Treated Red Ginseng Saponins, Glyceryl Caprylate, Helianthus Annuus Seed Oil Sunflower Seed Oil, Ethylhexylglycerin, Disodium Edta, Hydroxypropyl Cyclodextrin, Propanediol, Sorbitan Isostearate, Polysorbate 60, Methoxy Peg-114 Polyepsilon Caprolactone, Daucus Carota Sativa Root Extract Carrot Root Extract, Benzyl Salicylate, Bioflavonoids, Hydrolyzed Proanthocyanidin, Honey, Miel, Limonene, Hydrogenated Lecithin, Rehmannia Glutinosa Root Extract, Paeonia Albiflora Root Extract, Lilium Candidum Bulb Extract, Polygonatum Odoratum Extract Rhizome, Linalool, Panax Ginseng Extract Berry, Nelumbo Nucifera Flower Extract, Panax Ginseng Root Extract, Beta-Carotene, Tocopherol, Phytosphingosine, Sodium Polyaspartate, Caprylyl Glycol, Sodium Methyl Stearoyl Taurate, Acetyl Heptapeptide-4, Citric Acid, Acetyl Hexapeptide-8, Sodium Hydroxide, Acetyl Octapeptide-3

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.