SkinMedica TNS Advanced+ Serum for combination skin
Human Fibroblast Conditioned Media
Collagen Peptides
Trifluoroacetyl Tripeptide-2
Glycerin
Vitis Vinifera Flower Cell Extract Grape Flower Cell Extract
Average
- HighCombination Skin Fit
- AverageEffectiveness
- HighSafety
Works for combination skin; other serums fit it better.
This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate rejuvenation for your combination skin, as Human Fibroblast Conditioned Media and Trifluoroacetyl Tripeptide-2 help improve skin texture and reduce fine lines. Glycerin and Shea Ethyl Esters Butter provide essential hydration to support your oily shine concerns.
- The formula is highly suitable for combination skin, promoting collagen stimulation and extracellular matrix synthesis.
- This product is safe for your skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.
How to apply
- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
People Say
★4.5Overall rating based on 5.2k+ reviewsBased on a very large amount of data, this serum is highly praised for its potent anti-aging benefits, specifically targeting coarse wrinkles, fine lines, and sagging skin to produce a firmer, more radiant complexion. Users frequently report visible improvements in skin texture and elasticity. However, the product's high price tag and recurring issues with its dual-chamber pump packaging are common points of frustration.
Highlights
Improves fine lines Mostly Mentioned
- “can make the world of difference in your fine lines and wrinkles”
- “deeper lines around my mouth lessened significantly”
- “notice an improvement in fines lines”
- “creases in my forehead became more shallow”
Very expensive price Mostly Mentioned
- “The price tag is steep”
- “Expensive but fast results!”
- “The price is ridiculous”
- “A lot of money for a flawed product”
Firms sagging skin Often Mentioned
- “my skin had much more elasticity”
- “feels firmer, stays well hydrated”
- “preventing/restoring sagging skin”
- “plumps and firms with zero irritation”
Smoothes skin texture Often Mentioned
- “My skin looks smoother”
- “enhanced skin texture and tone”
- “overall glow to my skin”
- “visibly softer skin and improved texture”
Faulty pump dispenser Often Mentioned
- “One of the pumps failed on me”
- “The pumps did not work properly”
- “faulty pump & other issues”
- “dual pump failure issue”
Safe for sensitive skin Sometimes Noted
- “anti aging treatment that works for sensitive skin”
- “enhanced my skin without causing irritation”
- “plumps and firms with zero irritation”
- “Safe for sensitive skin”
Uneven product dispensing Sometimes Noted
- “serum ran out before the cream that you mix it with”
- “never know whether I'm getting enough from each side”
- “only have the clear serum but not the white one coming out”
- “They didn't dispense evenly”
Sources: lovi.care, dermapproved.com, lovelyskin.com, ellemesmedspa.com, walmart.com, theskinspot.com, and more
Questions and answers
How well does SkinMedica TNS Advanced+ Serum work for combination skin?
SkinMedica TNS Advanced+ Serum works decently for combination skin, helping smooth fine lines and provide hydration without causing irritation. However, combination skin often fits better with a product that includes ingredients like niacinamide, propolis, or zinc PCA to better regulate oiliness and boost radiance.
Clinical, Cosmetic and Investigational Dermatology, 2017Dermatologic Surgery, 2024
Which ingredients make this serum a good fit for combination skin?
Human Fibroblast Conditioned Media and Trifluoroacetyl Tripeptide-2 help improve skin texture and reduce fine lines, while glycerin and shea ethyl esters butter provide essential hydration to support your oily shine concerns. Treatments that fit combination skin better need effective ingredients like niacinamide, propolis, and zinc PCA to enhance radiance and regulate oiliness without any risk of irritation.
Clinical, Cosmetic and Investigational Dermatology, 2017Dermatologic Surgery, 2024
What does Human Fibroblast Conditioned Media do for combination skin?
Human Fibroblast Conditioned Media helps smooth fine lines and supports skin recovery for combination skin by delivering growth factors that encourage cell renewal. This type of ingredient may improve overall texture and help keep skin looking youthful and resilient.
Dermatologic Surgery, 2024Journal of Drugs in Dermatology, 2017
What do Collagen Peptides do for combination skin?
Collagen peptides help improve skin elasticity, moisture, and firmness for combination skin. Taking them daily helps smooth out fine lines and keeps skin looking healthy.
Where does this serum go in a skincare routine for combination skin?
This serum goes in your evening routine, applied after cleansing and before your moisturizer. Combination skin needs products with peptides and growth factors for texture, alongside lightweight hydrators that balance oily shine.
Can I use this serum with retinol, and in what order?
You can use this serum with retinol by applying the treatment after your cleanser and before your moisturizer at night. This product is very safe for your skin, with no risks of irritation from harsh ingredients.
How often should I use this serum?
This serum works well in your evening routine for combination skin. To get better results for this skin type, a product of this type needs peptides, growth factors, and lightweight hydrators like glycerin that improve texture and smooth fine lines without adding extra oil.
Can this serum clog pores, cause breakouts or purging for combination skin?
This serum is unlikely to clog pores or cause breakouts for combination skin, as it is free of heavy, pore-clogging oils and harsh ingredients. It helps smooth fine lines while balancing hydration without leaving an overly oily feel.
Is this serum fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Topical application of human fibroblast conditioned media and its derived growth factors and exosomes significantly reduces signs of skin aging and stimulates skin recovery and quality after in-office cosmetic procedures.
Dermatologic Surgery, 2024Exposure to collagen peptides increased the expression of COL1A1, ELN, and VCAN genes and collagen protein levels in cultured human dermal fibroblasts compared to untreated controls.
Frontiers in Medicine, 2024Collagen peptides induced cell proliferation and pro-collagen-1α expression, increased TGF-β and VEGF, and suppressed the LPS-induced inflammatory response in human skin fibroblasts and keratinocytes.
Nutrients, 2022A liquid formulation containing hydrolyzed collagen demonstrated structural stability, peptide mass distribution between 0.5 and 19.5 kDa, and faded forehead wrinkles in five volunteers while proving to be non-irritating and hypoallergenic.
Journal of Cosmetic Dermatology, 2021Salmo salar and Tilapia nilotica skin collagen peptides accelerate wound healing in a rat murine wound model by reducing proinflammatory cytokines, upregulating BD14, NOD2, IL-10, VEGF, and beta-FGF, and favorably altering wound microflora colonization compared to untreated controls.
Journal of Agricultural and Food Chemistry, 2020Cod skin collagen peptide/chitosan-based temperature-sensitive gel (CS/CSCPs/β-GP gel) synergistically enhanced the anti-photoaging effect of CSCPs in an ultraviolet-irradiated mouse model by inhibiting ROS, suppressing inflammatory factors, and preventing collagen degradation.
Drug Design, Development and Therapy, 2023The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.
Journal of Cosmetic Dermatology, 2020Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.
International Journal of Cosmetic Science, 2001Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects.
Journal of Drugs in Dermatology, 2012
Ingredients
Water, Pentylene Glycol, Human Fibroblast Conditioned Media, Glycereth-7 Triacetate, Shea Ethyl Esters Butter, Glycerin, Ethoxydiglycol, Lactococcus Lysate Ferment, Whey Protein, Chlorella Vulgaris Extract, Saccharide Isomerate, Trifluoroacetyl Tripeptide-2, Dimer Tripeptide-43, Hydrolyzed Linseed Extract, Vitis Vinifera Flower Cell Extract Grape Flower Cell Extract, Pyrus Malus Fruit Extract, Hydroxyacetophenone, Tocopheryl Acetate, Propanediol, Xanthan Gum, Polyacrylate Crosspolymer-6, Polyacrylate-13, Polyisobutene, Sclerotium Gum, Peg-12 Dimethicone, Lecithin, Pullulan, Butylene Glycol, Sodium Citrate, Polysorbate 20, Aminomethyl Propanol, Dextran, Disodium Edta, Phenoxyethanol, Ethylhexylglycerin
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
Scan your face, then any product: Lovi shows how well it fits you and what fits even better.