REJURAN Turnover Active Cream for mature skin

How to apply

Questions and answers

What the research says

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone.

  Dermatologic Therapy, 2022

• Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants.

  International Journal of Molecular Sciences, 2026

• Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer.

  The British Journal of Dermatology, 2002

• Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

  Journal of Cosmetic Dermatology, 2021

• Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

  The Journal of Investigative Dermatology, 2008

• Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

  Dermatologic Surgery, 2005

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• Lipid extracts of Chlorella vulgaris and Arthrospira platensis protect Normal Human Dermal Fibroblasts against UVA-induced oxidative stress and 2-propanol-induced IL-6 expression in vitro.

  Food Science and Technology International = Ciencia Y Tecnologia de Los Alimentos Internacional, 2026

• Oral and topical administration of ROQUETTE Chlorella sp. at higher doses significantly reduced skin inflammation scores and improved the healing process and duration of skin wounds in mice compared to untreated models.

  Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry, 2014

• Resilient factor (RF, an aqueous extract fraction of Chlorella) suppressed PMA- and UVB-induced MMP1 production, protein, and gene expression, prevented UVB-suppressed elastin protein, and increased pro-collagen mRNA expression in human skin fibroblasts compared to untreated controls.

  European Journal of Dermatology, 2008

• Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months.

  The Journal of Dermatology, 2008

• Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts.

  International Journal of Molecular Sciences, 2021

• Adenosine treatment of dermal papilla cells upregulates fibroblast growth factor-7 expression via the A2b adenosine receptor and intracellular cAMP signaling, and fibroblast growth factor-7 significantly stimulates hair fiber elongation in human scalp hair follicle organ cultures.

  The Journal of Investigative Dermatology, 2007

• Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment.

  American Journal of Clinical Dermatology, 2002

• Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects.

  Journal of Cosmetic Dermatology, 2019

• Topical dexpanthenol formulated in lipophilic vehicles improved stratum corneum hydration and reduced transepidermal water loss compared to vehicle control in humans.

  Arzneimittel-Forschung, 2000

Why other moisturizers fit mature skin better

• Combining oral and topical astaxanthin in 30 healthy females improved skin wrinkles, age spots, elasticity, texture, and moisture, while 6 mg daily oral supplementation in 36 healthy males improved crow's feet wrinkles, elasticity, and transepidermal water loss.

  Acta Biochimica Polonica, 2012

• Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days.

  Annals of Dermatology, 2019

• A supramolecular system of malic acid-derived ionic liquid and acetyl hexapeptide-8 enhanced transdermal permeation by 3.10 times, increased collagen production, inhibited acetylcholine release, and reduced wrinkle number, length, and area compared to peptide monotherapy in human subjects.

  Journal of Materials Chemistry. B, 2025

Ingredients

Water, Glycerin, Butylene Glycol, Methyl Hydrogenated Rosinate, Dipropylene Glycol, Distarch Phosphate, Dicaprylyl Carbonate, Cetearyl Alcohol, Niacinamide, Pentylene Glycol, Polyglyceryl-3 Methylglucose Distearate, 1,2-Hexanediol, Chlorella Vulgaris Extract, Vincetoxicum Atratum Extract, Caesalpinia Spinosa Fruit Extract, Althaea Rosea Flower Extract, Kappaphycus Alvarezii Extract, Prunus Amygdalus Dulcis Seed Extract, Hyaluronic Acid, Bis-Diglyceryl Polyacyladipate-2, Octyldodecanol, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Tromethamine, Fructooligosaccharides, Fructose, Panthenol, Cetearyl Glucoside, Adenosine, Sodium Phytate, Tocopherol, Ethylhexylglycerin, Trehalose, Urea, Glyceryl Polyacrylate, Serine, Caprylyl Glycol, Algin, Pullulan, Disodium Phosphate

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.