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Perricone MD Rejuvenating Moisturizer for mature skin

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes

Perricone MD Rejuvenating Moisturizer

Average

  • AverageNormal Skin Fit
  • HighEffectiveness
  • HighSafety

Works for mature skin; other moisturizers fit it better.

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.

Page built Nov 8, 2026How the Fit score works

Lovi Assistant explains

  • Offers moderate suitability for your normal skin, as glycerin and macadamia ternifolia seed oil provide excellent moisturization and barrier support, while tetrahexyldecyl ascorbate and palmitoyl glycine address wrinkles and fine lines by supporting collagen production.
  • The inclusion of ribose and lactic acid offers mild exfoliation and skin renewal, complementing the primary anti-aging benefits.
  • The product is safe for your skin, with rosemary leaf extract providing soothing properties and no harsh or prohibited ingredients present.

How to apply

  • Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
  • Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
  • Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
  • Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
  • Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.

People Say

★4.6Overall rating based on 1.0k+ reviews

This moisturizer is praised for its rich texture that plumps, firms, and smooths aging or dry skin without greasiness. Many users report reduced fine lines and improved radiance. Some users experienced product pilling or sensitivity to the fragrance.

Highlights

  • Deeply hydrating Often Mentioned
    • “Keeps my skin moist without the acne.”
    • “Very rich and nourishing.”
    • “Replenishes fragile skin.”
  • Improves texture Often Mentioned
    • “Skin looks smoother, with no discoloration.”
    • “Visibly plumper, firmer, and smoother.”
    • “Skin feels better, smoother and brighter.”
  • Non-greasy formula Sometimes Noted
    • “It's non greasy, absorbs right in.”
    • “Absorbs quickly without any residual grease.”
    • “Not greasy or sticky.”
  • Reduces lines Sometimes Noted
    • “Plumps my skin to reduce the look of fine lines.”
    • “Targets deep wrinkles and creases.”
    • “Saw a reduction in the appearance of fine lines.”
  • Product pilling Sometimes Noted
    • “When I try to apply my liquid makeup over it it rolls up.”
    • “It all pealed away. It looked like a snow storm.”
    • “I do not really experience pilling unless I use too much.”
  • Fragrance sensitivity Rarely Noted
    • “A few reviewers found the fragrance too strong.”
    • “Unfortunately had an allergic reaction.”
    • “Experienced minor irritation.”
  • White cast Rarely Noted
    • “Leaves this white flaky texture on my face.”
    • “Had to really blend so it didn't appear to leave a white cast.”
    • “Doesn't leave a whitecast (after 7 days).”

Sources: lovi.care, perriconemd.com, lovelyskin.com, walmart.com, ipsy.com, nordstrom.com, and more

Questions and answers

How well does Perricone MD Rejuvenating Moisturizer work for mature skin?

Perricone MD Rejuvenating Moisturizer works reasonably well for mature skin, as it uses glycerin and macadamia nut oil to keep skin soft and supported, while vitamin C and peptides help smooth out fine lines. It also provides gentle renewal with lactic acid and ribose, though other options may offer even better results for your skin type. To truly thrive, a product for mature skin needs a rich blend of deeply nourishing hydrators, powerful smoothing ingredients, and soothing components that keep the skin barrier strong and irritation-free.

Clinical, Cosmetic and Investigational Dermatology, 2017

Which ingredients make this cream a good fit for mature skin?

Tetrahexyldecyl ascorbate and palmitoyl glycine make this cream a good fit for mature skin because they help smooth wrinkles and fine lines by supporting collagen, while glycerin and macadamia seed oil keep skin soft with deep moisture. To fit mature skin even better, a product like this needs exceptionally safe anti-aging ingredients, potent nourishment for fine lines, and rich moisturizing components that prevent irritation.

International Journal of Cosmetic Science, 2010

What does Acyl-Glutathione do for mature skin?

Acyl-Glutathione helps mature skin by smoothing fine wrinkles and keeping the skin hydrated while providing strong antioxidant protection. Topical application of glutathione-based products is safe and may improve skin quality and brightness.

The Journal of Clinical and Aesthetic Dermatology, 2025Giornale Italiano Di Dermatologia E Venereologia, 2019

What does Vitamin C do for mature skin?

Vitamin C helps smooth out wrinkles, fade dark spots, and calm redness on mature skin. It also boosts collagen production to make skin firmer and protects against everyday environmental stress.

The Journal of Clinical and Aesthetic Dermatology, 2017Dermatologic Surgery, 2002

Where does it go in a skincare routine for mature skin?

This moisturizing treatment goes in the morning routine after a hydrating toner and before SPF, or in the evening routine as your moisturizer step. It helps keep skin soft and supports your skin barrier, though a product for mature skin also needs strong anti-aging ingredients like retinol or peptides for better results.

The Journal of Dermatological Treatment, 2022

Can I use this cream with retinol, and in what order?

You can use this cream with retinol by applying your retinol first and following with this moisturizer to help keep your skin comfortable. Using a moisturizing cream with retinol helps reduce dryness and supports your skin barrier while you treat fine lines.

Cutis, 2006

How often should I use it?

You can use this moisturizing treatment twice daily to help keep your mature skin soft, smooth, and well-hydrated. Regular application may also support collagen production and improve the look of fine lines over time.

Journal of Cosmetic Dermatology, 2020Journal of Drugs in Dermatology, 2015

Can this cream clog pores, cause breakouts or purging for mature skin?

This cream is unlikely to clog pores or cause breakouts for mature skin, as it has a safe formula with no harsh ingredients. However, to truly thrive, mature skin needs rich nourishing oils and deep barrier support to stay soft and smooth.

Clinical, Cosmetic and Investigational Dermatology, 2017

Can I use it around the eyes or on my body?

You can use this moisturizer on your body, but it is not specifically tailored for the very thin skin around the eyes. To properly care for mature skin, a product of this type needs rich nourishing oils, targeted collagen-supporting ingredients, and gentle renewing agents to keep the skin feeling soft and smooth.

Surgical and Radiologic Anatomy, 2002

Is this cream fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (parfum, citronellol, limonene, and linalool). Cetearyl alcohol is a fatty alcohol, which soften the skin.

What the research says

Ingredients

Water, Ethylhexyl Palmitate, Glycerin, Dimethicone, Cetearyl Alcohol, Glyceryl Stearate, Polysorbate 60, Palmitoyl Glycine, S-Palmitoylglutathione, Tetrahexyldecyl Ascorbate, Peg-100 Stearate, Ribose, Lactic Acid, Linum Usitatissimum Seed Oil, Macadamia Ternifolia Seed Oil, Polyglyceryl-10 Stearate, Ethylhexylglycerin, Salvia Hispanica Seed Oil, Tocopherol, Helianthus Annuus Seed Oil Sunflower Seed Oil, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Tetrasodium Glutamate Diacetate, Sodium Hydroxide, Polyacrylamide, Sodium Acrylates Copolymer, Polysilicone-11, Hydrogenated Polyisobutene, C13-14 Isoparaffin, Laureth-7, Phenoxyethanol, Parfum, Citronellol, Hydroxycitronellal, Limonene, Linalool

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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How does it fit your skin?

Scan your face, then any product: Lovi shows how well it fits you and what fits even better.

QR code: get the Lovi app
Download on theApp Store Get it onGoogle Play