MISSHA Time Revolution Night Repair Ampoule Cream 5X for skin with dark spots

How to apply

Questions and answers

What the research says

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Topical application of Bifida Ferment Lysate strengthens the skin barrier function by upregulating barrier and antimicrobial peptide genes, exhibiting strong antioxidant properties, and decreasing inflammatory cytokine secretion in vitro.

  Journal of Cosmetic Dermatology, 2023

• Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

  Journal of Cosmetic Dermatology, 2021

• Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

  The Journal of Investigative Dermatology, 2008

• Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

  Dermatologic Surgery, 2005

• Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing.

  Journal of Alternative and Complementary Medicine, 2020

• Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects.

  Journal of Cosmetic Dermatology, 2019

• Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline.

  Experimental Dermatology, 2008

Why other moisturizers fit skin with dark spots better

• Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2014

• Combining oral and topical astaxanthin in 30 healthy females improved skin wrinkles, age spots, elasticity, texture, and moisture, while 6 mg daily oral supplementation in 36 healthy males improved crow's feet wrinkles, elasticity, and transepidermal water loss.

  Acta Biochimica Polonica, 2012

Ingredients

Water, Glycerin, Methyl Propanediol, Cyclohexasiloxane, Hydrogenated Polyisobutene, Caprylic Capric Triglyceride, Triethylhexanoin, Cetearyl Alcohol, Niacinamide, Dimethicone, 1,2-Hexanediol, Trehalose, Stearyl Alcohol, Beeswax, Cetyl Alcohol, Phytosteryl Isostearyl Cetyl Stearyl Behenyl Dimer Dilinoleate, Cetearyl Glucoside, Vinyl Dimethicone, Polyglyceryl-2 Stearate, Glyceryl Stearate, Palmitic Acid, Stearic Acid, Bergamot Oil Fruit, Hydroxyacetophenone, Dioscorea Japonica Root Extract, Ammonium Acryloyldimethyltaurate Vp Copolymer, Ethylhexylglycerin, Glycosyl Trehalose, Butylene Glycol, Alcohol, Bifida Lysate Ferment, Hydrogenated Hydrolysate Starch, Xanthan Gum, Adenosine, Raffinose, Glyceryl Polymethacrylate, Dextrin, Theobroma Cacao Shell Powder, Pelargonium Graveolens Oil Flower, Lecithin, Disodium Edta, Hydrogenated Lecithin, Camellia Sinensis Seed Oil, Argania Spinosa Kernel Oil, Olea Europaea Oil Fruit Olive Oil Fruit, Helianthus Annuus Seed Oil Sunflower Seed Oil, Jojoba Seed Oil, Camellia Japonica Seed Oil, Macadamia Ternifolia Seed Oil, Glucose, Centella Asiatica Extract, Ficus Carica Fruit Extract, Polyquaternium-51, Cetearyl Olivate, Ceramide Np, Lavandula Angustifolia Oil Lavender Oil, Citrus Aurantium Dulcis Peel Oil, Sorbitan Olivate, Phellodendron Amurense Bark Extract, Lactobacillus Ferment, Myristic Acid, Lactobacillus Acerola Cherry Ferment, Lactococcus Ferment, Leuconostoc Radish Root Ferment Filtrate, Bifida Ferment Filtrate, Lactobacillus Soybean Extract Ferment, Lactobacillus Punica Granatum Extract Fruit Ferment, Lactobacillus Lysate Ferment, Lactococcus Lysate Ferment, Monascus Extract, Sucrose Distearate, Rice Extract, Dipropylene Glycol, Biosaccharide Gum-1, Saccharomyces Ferment, Beta Vulgaris Root Extract, Daucus Carota Sativa Root Extract Carrot Root Extract, Brassica Oleracea Capitata Leaf Extract, Blueberry Fruit Extract, Solanum Melongena Fruit Extract, Anthemis Nobilis Oil Flower, Tocopherol, Sandalwood Oil, Bacillus Ferment

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.