MISSHA Time Revolution Night Repair Ampoule 5X for dry sensitive skin
Bifida Lysate Ferment
Niacinamide
Sodium Hyaluronate
Squalane
Extreme Biome
High
- HighDry Skin Fit
- HighEffectiveness
- HighSafety
One of the best serums for dry sensitive skin.
This fit is calculated for the concerns frequently associated with dry sensitive skin: flakiness, tightness, redness, fine lines, and wrinkles. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- This product offers excellent skin repair for your dry and sensitive skin, as Bifida Lysate Ferment and Niacinamide work to enhance barrier resilience and even skin tone. Glycerin and Panthenol provide moderate hydration, addressing dryness and flakiness effectively.
- The inclusion of Squalane and Sodium Hyaluronate further supports barrier repair and offers additional humectant benefits, making it highly suitable for your dry skin type.
- The formulation is safe for your skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.
How to apply
- Use this PM routine for your evening skincare. Start using the serum 3 times a week and increase to daily use if your skin feels comfortable.
- Apply the serum after cleansing and toner, but right before your moisturizer. This step locks in deep hydration for dry skin.
- Gently press 2-3 drops of the serum into your skin using your palms. Let it absorb completely for a minute ⏱ before applying your next product.
- Since your skin is sensitive, apply the serum on completely dry skin for better tolerance and less irritation.
- Avoid the sensitive eye area during application. Always do a patch test before your first use to ensure your skin reacts well.
People Say
★4.7Overall rating based on 700+ reviewsUsers consistently praise this ampoule as a powerful anti-aging treatment that delivers deep hydration and a "glass skin" glow overnight, often comparing it favorably to the much more expensive Estée Lauder Advanced Night Repair. It is particularly effective for dry, mature, and sensitive skin types, helping to smooth rough texture and plump fine lines, though a minority of users with sensitivities to fermented ingredients or essential oils experienced irritation.
Highlights
Hydration and glow Mostly Mentioned
- “leaves my skin hydrated, soft, and glowy”
- “woke up with plump and glowy skin”
- “restores elasticity and radiance”
- “deeply moisturizes without being heavy”
Estée Lauder dupe Often Mentioned
- “best dupe for Estée Lauder's ANR”
- “works better than much more expensive serums”
- “fraction of the price of high-end brands”
- “similar texture to ANR but affordable”
Improves skin texture Often Mentioned
- “makes my skin so smooth”
- “softens rough texture overnight”
- “skin feels velvety soft”
- “helped evening out texture”
Fast absorption Sometimes Noted
- “absorbs pretty quickly”
- “non-sticky feel when massaged in”
- “layers nicely with other products”
- “lightweight and sinks in fast”
Scent irritation Sometimes Noted
- “smell is a bit strong”
- “contains essential oils like lavender and bergamot”
- “scent might be irritating for some”
- “wish it was fragrance-free”
Breakouts or irritation Rarely Noted
- “caused small bumps”
- “broke me out after a few days”
- “too sensitizing for my reactive skin”
- “reaction to the fermented ingredients”
Opaque packaging Rarely Noted
- “can't tell how much product is left”
- “bottle is too dark to see inside”
- “ran out unexpectedly”
- “hard to gauge remaining amount”
Sticky finish Rarely Noted
- “slightly sticky when it absorbs”
- “sits on top of my skin”
- “feels a bit tacky”
- “hair sticks to face after application”
Sources: lovi.care, iherb.com, misshaus.com, sokoglam.com, yesstyle.com, walmart.com, and more
Questions and answers
What makes MISSHA Time Revolution Ampoule 5X a great fit for dry sensitive skin?
This treatment is a great fit because ingredients like glycerin, panthenol, squalane, and sodium hyaluronate soothe dryness and flakiness while keeping your skin hydrated. It also helps repair your skin barrier and even out your skin tone with bifida lysate ferment and niacinamide, and it is very safe for sensitive skin without harsh or prohibited ingredients.
The British Journal of Dermatology, 2002American Journal of Clinical Dermatology, 2002
Which ingredients make this serum a good fit for dry sensitive skin?
Bifida Lysate Ferment and Niacinamide help strengthen your skin barrier, while Glycerin, Panthenol, Squalane, and Sodium Hyaluronate provide essential moisture to soothe dryness and flakiness. These ingredients work safely together to keep dry and sensitive skin calm and smooth.
The British Journal of Dermatology, 2002American Journal of Clinical Dermatology, 2002
What does Bifida Ferment Lysate do for dry sensitive skin?
Bifida Ferment Lysate helps soothe dry sensitive skin by calming irritation and keeping moisture locked in. It strengthens your skin barrier so it stays soft and smooth against everyday stress. Using a product with this ingredient may also lower redness and keep your skin comfortable.
Scientific Reports, 2023Journal of Cosmetic Dermatology, 2023
What does Niacinamide do for dry sensitive skin?
Niacinamide helps dry sensitive skin by calming irritation and keeping moisture locked in so your face feels soft and smooth. It works to build up your skin barrier and calm redness while being very gentle and unlikely to cause irritation.
Journal of Cosmetic Dermatology, 2004International Journal of Pharmaceutics, 2013
Where does this serum go in a skincare routine for dry sensitive skin?
This serum goes in your evening routine as a treatment step after your soothing toner and before your moisturizer. Using treatments in the evening helps keep things simple and provides extra safety around sun exposure.
Can I use this serum with retinol, and in what order?
You can use this serum with retinol by applying it as your treatment step in the evening routine after cleansing and toning, and before your moisturizer. It helps soothe dryness and strengthen your skin, and is unlikely to cause irritation.
How often should I use this serum?
You can use this treatment in your evening routine. Using it daily helps address dryness and flakiness while keeping your skin calm.
Can this serum clog pores, cause breakouts or purging for dry sensitive skin?
This serum is unlikely to cause breakouts or clogged pores for dry sensitive skin, as it has a very low likelihood of causing irritation or breakouts according to reviews. Its gentle ingredients like Squalane and Sodium Hyaluronate help keep your skin smooth and calm without heavy residue.
Is this serum fragrance-free and alcohol-free?
It has no drying alcohol and contains fragrance (limonene).
What the research says
Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer.
The British Journal of Dermatology, 2002Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment.
American Journal of Clinical Dermatology, 2002A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability.
The Journal of Dermatological Treatment, 2017Hyaluronic acid extracts are safe and efficacious products for skin repair when used in tissue regeneration alone or in combination with herbal or Western medicine.
Journal of Pharmacy & Pharmaceutical Sciences, 2015Application of squalene/phosphotungstate calcium nanowires (Sql/PWC) oleogel on UVB-irradiated skin decreased epidermal thickness, increased dermal thickness, and promoted the expression of elastin, collagen, and skin barrier markers through antioxidant and anti-inflammatory activities.
Journal of Nanobiotechnology, 2025Topical application of Bifida Ferment Lysate strengthens the skin barrier function by upregulating barrier and antimicrobial peptide genes, exhibiting strong antioxidant properties, and decreasing inflammatory cytokine secretion in vitro.
Journal of Cosmetic Dermatology, 2023Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.
Journal of Drugs in Dermatology, 2011Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.
Clinical Oral Investigations, 2022Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.
BMC Oral Health, 2019Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts.
Molecules, 2025Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway.
Antioxidants, 2025
Ingredients
Bifida Lysate Ferment, Butylene Glycol, Glycerin, Propanediol, Betaine, Water, Niacinamide, Pentylene Glycol, 1,2-Hexanediol, Diethoxyethyl Succinate, Chondrus Crispus Extract, Squalane, Panthenol, Polyglyceryl-10 Laurate, Saccharum Officinarum Extract, Hydrogenated Lecithin, Carbomer, Tromethamine, Xanthan Gum, Polyquaternium-51, Ethylhexylglycerin, Adenosine, Dextrin, Theobroma Cacao Extract, Bergamot Oil Fruit, Disodium Edta, Sodium Hyaluronate, Lactobacillus Ferment, Lactobacillus Lysate Ferment, Bifida Ferment Filtrate, Lactobacillus Acerola Cherry Ferment, Lactobacillus Punica Granatum Extract Fruit Ferment, Lactobacillus Soybean Extract Ferment, Lactococcus Ferment, Lactococcus Lysate Ferment, Leuconostoc Radish Root Ferment Filtrate, Pelargonium Graveolens Oil Flower, Beta Vulgaris Root Extract, Brassica Oleracea Capitata Leaf Extract, Daucus Carota Sativa Root Extract Carrot Root Extract, Solanum Melongena Fruit Extract, Blueberry Fruit Extract, Helianthus Annuus Seed Oil Sunflower Seed Oil, Citrus Aurantium Dulcis Peel Oil, Lavandula Angustifolia Oil Lavender Oil, Lupinus Albus Seed Extract, Aspergillus Ferment, Swiftlet Nest Extract, Anthemis Nobilis Oil Flower, Sandalwood Oil, Tocopherol, Ceramide Np, Cholesterol, Limonene
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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