MISSHA Super Aqua Oil Clear Toner for acne-prone skin

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Questions and answers

What the research says

• Topical 5% tea tree oil gel significantly improved total acne lesions and acne severity index compared to placebo in 60 patients with mild to moderate acne vulgaris, showing 3.55 times and 5.75 times greater efficacy respectively.

  Indian Journal of Dermatology, Venereology and Leprology, 2007

• A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo.

  Clinical Pharmacology, 2018

• Tea tree oil nanoemulsion containing adapalene gel demonstrated significantly greater reductions in total, inflammatory, and non-inflammatory acne lesions as well as acne severity index compared to adapalene marketed gel in 100 patients with acne vulgaris over 12 weeks.

  Archives of Dermatological Research, 2022

• Hamamelis bark proanthocyanidins strongly increased the proliferation of cultured human keratinocytes and reduced transepidermal water loss and erythema formation in SLS-irritated skin, whereas the polysaccharide fraction had no effect.

  Phytochemistry, 2001

• A Hamamelis virginiana leaf extract increased LOXL1 expression twofold, decreased elafin synthesis, restored functional elastic fibers, reduced nonfunctional elastin aggregates, decreased wrinkles, and improved skin firmness.

  Journal of Cosmetic Science, 2018

• Witch hazel bark extract and hamamelitannin showed pronounced anti-inflammatory activity, supported keratinocyte migration in a wound healing assay, and inhibited Staphylococcus aureus growth, whereas their skin microbiota metabolite ellagic acid stimulated inflammatory mediator release.

  Journal of Ethnopharmacology, 2025

• Hamamelis virginiana bark extract inhibited Cutibacterium acnes-induced IL-6 release and TNF-α-induced IL-8 release in human keratinocytes without showing antibacterial or antibiofilm activities.

  Antioxidants, 2022

• Melaleuca alternifolia essential oil and its nanoemulsion improved skin morphology, papillary depth, dermis echogenicity, and collagen fibers in 40 male participants compared to a vehicle formulation over 90 days, with the nanoemulsion achieving deeper skin layer penetration.

  Photochemistry and Photobiology, 2023

• Topical tea tree oil treatment confirmed efficacy on Demodex mite blepharitis across fourteen papers evaluating chronic blepharitis compared to no treatment or alternative management.

  BioMed Research International, 2022

• Weekly treatment with tea tree oil-saturated human amniotic membrane showed superior efficacy in healing pityriasis versicolor lesions and fungicidal activity compared to daily application of 1% tioconazole cream in 120 patients.

  Cell and Tissue Banking, 2020

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.

  Journal of Cosmetic Dermatology, 2020

• Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.

  International Journal of Cosmetic Science, 2001

• Resilient factor (RF, an aqueous extract fraction of Chlorella) suppressed PMA- and UVB-induced MMP1 production, protein, and gene expression, prevented UVB-suppressed elastin protein, and increased pro-collagen mRNA expression in human skin fibroblasts compared to untreated controls.

  European Journal of Dermatology, 2008

• Topical treatment with a novel marine polysaccharide PCA extracted from Chaetomorpha aerea accelerated wound healing, enhanced collagen deposition, and reduced wound size in rats compared to control groups.

  Current Pharmaceutical Biotechnology, 2025

Ingredients

Witch Hazel Water, Water, Propanediol, Glycerin, Pyrus Malus Fruit Water, Rosa Canina Fruit Extract, Pyrus Malus Fruit Extract, Melaleuca Alternifolia Tree Leaf Extract, Codium Tomentosum Extract, Ecklonia Cava Extract, Enteromorpha Compressa Extract, Macrocystis Pyrifera Extract Kelp Extract, Gelidium Cartilagineum Extract, Laminaria Japonica Extract, 1,2-Hexanediol, Butylene Glycol, Calcium Chloride, Lithium Magnesium Sodium Silicate, Choleth-24, Dipropylene Glycol, Silica, Dimethicone, Ethylhexylglycerin, Lecithin, Polyglutamic Acid, Sodium Hyaluronate, Disodium Edta, Phenoxyethanol, Parfum

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.