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ma:nyo Bifida Complex Ampoule for combination skin

Rated by Lovi 路 Unbiased, science-based skincare AI trained on real user outcomes

ma:nyo Bifida Complex Ampoule

Average

  • HighCombination Skin Fit
  • AverageEffectiveness
  • HighSafety

Works for combination skin; other serums fit it better.

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.

Page built Nov 8, 2026How the Fit score works

Lovi Assistant explains

  • Offers moderate benefits for your combination skin, as Bifida Lysate Ferment and Niacinamide provide general skin conditioning and seboregulation to help manage oily shine.
  • The formulation also supports skin barrier resilience with Lactobacillus Pumpkin Fruit Ferment Filtrate, contributing to overall skin health.
  • The product is safe for your combination skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

How to apply

  • Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
  • Apply the serum after cleansing and toner, and right before your moisturizer.
  • Gently press 2-3 drops of the serum into your skin and wait a minute 鈴砯or it to soak in.
  • Apply the serum on clean and dry skin since your skin is not sensitive.
  • Always do a patch test before using the serum for the first time, and avoid the eye area .

Questions and answers

How well does the Bifida Complex Ampoule work for combination skin?

This ampoule works moderately well for your combination skin by helping manage oily shine and supporting your skin barrier with ingredients like Bifida Lysate Ferment and niacinamide. A treatment for this skin needs effective ingredients like niacinamide, propolis, or zinc PCA that regulate oiliness and provide balanced hydration without causing excess oiliness or dryness.

Which ingredients make this serum a good fit for combination skin?

Bifida lysate ferment and niacinamide make this serum a good fit for combination skin by providing general conditioning and helping manage oily shine, while lactobacillus pumpkin fruit ferment filtrate supports skin barrier resilience. A treatment for this skin needs effective ingredients like niacinamide, propolis, or zinc PCA to regulate oiliness, enhance radiance, and provide balanced hydration without excess oil or dryness.

What does Bifida Ferment Lysate do for combination skin?

Bifida Ferment Lysate helps strengthen the skin barrier and calm irritation, making it a great addition for balancing combination skin. It works by supporting the skin defenses and increasing moisture while keeping the skin calm.

Journal of Cosmetic Dermatology, 2023Scientific Reports, 2023

What does Niacinamide do for combination skin?

Niacinamide helps balance oily areas by reducing excess shine and pore size while keeping dry patches hydrated and smooth. It also works to calm redness and even out skin tone, making it very suitable for combination skin.

The British Journal of Dermatology, 2002Antioxidants, 2021

Where does this serum go in a skincare routine for combination skin?

Apply this treatment in the evening as part of your routine for combination skin. The product is safe for your skin and helps manage oily shine while supporting your skin barrier, though a product of this type for combination skin needs balancing ingredients like niacinamide and ferment filtrates for the best fit.

Can I use this serum with retinol, and in what order?

You can use this treatment with retinol by applying the treatment first and following with your retinol product, or by using this treatment in the morning and retinol at night to keep your skin calm.

How often should I use this serum?

You can use this treatment in your evening routine, applying it once a day or a few times a week as your skin adjusts. For a better fit on combination skin, a product of this type needs ingredients like hyaluronic acid and niacinamide to deeply hydrate dry areas while managing oily shine.

Can this serum clog pores, cause breakouts or purging for combination skin?

This serum is unlikely to clog pores or cause breakouts on combination skin because it has a safe formula with no harsh or heavy ingredients that typically cause irritation. It helps manage oily shine while keeping your skin balanced, though combination skin sometimes needs lighter hydration and targeted pore-clearing ingredients to prevent congestion entirely.

Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

What the research says

  • Topical application of Bifida Ferment Lysate strengthens the skin barrier function by upregulating barrier and antimicrobial peptide genes, exhibiting strong antioxidant properties, and decreasing inflammatory cytokine secretion in vitro.

    Journal of Cosmetic Dermatology, 2023

  • Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

    Journal of Cosmetic Dermatology, 2021

  • Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

    The Journal of Investigative Dermatology, 2008

  • Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

    Dermatologic Surgery, 2005

  • Topical treatment with pumpkin seed oil-loaded niosomes decreased fallen hairs by 44.42% and increased the anagen to telogen ratio by 1.4-fold after 8 weeks compared to initial conditions.

    Pharmaceuticals, 2022

  • Topical application of prickly pear, pumpkin, and linseed oils significantly reduced clinical signs of acute inflammation, inflammatory markers, and oxidative stress in carrageenan-treated rats compared to the normal saline-treated group.

    BioMed Research International, 2020

  • Enzyme-modified ginseng extract cream significantly reduced the global photo-damage score and various roughness measures including total roughness, smoothness depth, and arithmetic roughness average compared to placebo in 23 human subjects.

    Rejuvenation Research, 2015

  • A red ginseng hydrogel formulation with 1,2-hexanediol promoted selective growth of Staphylococcus epidermidis and decreased Cutibacterium acnes in 20 female subjects.

    Journal of Ginseng Research, 2022

  • A 1% fermented black ginseng cream significantly reduced eye wrinkles and brightened skin color in twenty-three human subjects compared to control cream and baseline.

    Journal of Toxicology and Environmental Health. Part A, 2020

  • Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

    Journal of Drugs in Dermatology, 2011

  • Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

    Clinical Oral Investigations, 2022

  • Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

    BMC Oral Health, 2019

Ingredients

Bifida Lysate Ferment, Lactobacillus Pumpkin Fruit Ferment Filtrate, Niacinamide, Butylene Glycol, Acetyl Hexapeptide-8, Aureobasidium Pullulans Ferment, Hydrolyzed Algin, Caffeine, Panax Ginseng Root Extract, Panax Ginseng Callus Culture Extract, Glycerin, Epigallocatechin Gallate, Zanthoxylum Piperitum Fruit Extract, Pulsatilla Koreana Extract, Usnea Barbata Extract, Copper Tripeptide-1, Physalis Alkekengi Fruit Extract, Methyl Gluceth-20, Sodium Hyaluronate, Adenosine

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sof铆a Perea P茅rez, MD, MSc

    Dr. Sof铆a Perea P茅rez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

How does it fit your skin?

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How does it fit your skin?

Scan your face, then any product: Lovi shows how well it fits you and what fits even better.

QR code: get the Lovi app
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