iS Clinical Active Serum for sensitive skin
Saccharum Officinarum Extract
Vaccinium Myrtillus Extract
Arbutin
Willow Bark Extract
Polyporus Umbellatus Extract Mushroom Extract
Average
- HighNormal Skin Fit
- AverageEffectiveness
- HighSafety
Works for sensitive skin; other serums fit it better.
This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate exfoliation and hydration for your normal skin, with glycerin and willow bark extract providing mild benefits for redness and irritation.
- The inclusion of saccharum officinarum extract and vaccinium myrtillus leaf extract further supports gentle exfoliation and skin clarity.
- The product is safe for your sensitive skin, as it lacks any harsh or prohibited ingredients that could cause irritation.
How to apply
- Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
- Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
- Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
- Always do a patch test before your first use and avoid getting the serum too close to your eyes .
People Say
★4.6Overall rating based on 1000+ reviewsUsers consistently praise this serum as a "holy grail" multitasker that effectively targets adult acne while simultaneously smoothing fine lines and uneven texture. While the potent "tingling" sensation confirms its activity for most, the high price point and potential for dryness are common considerations for new users.
Highlights
Clears Acne & Breakouts Mostly Mentioned
- “breakouts have been less severe and fewer”
- “helps prevent breakouts”
- “cystic acne is gone”
- “eradicate blackheads”
Improves Texture & Tone Often Mentioned
- “skin feels softer”
- “smooths skin texture”
- “pores look smaller”
- “glows after 2 days”
High Price Point Often Mentioned
- “expensive for small bottle”
- “wish it was cheaper”
- “investment product”
- “pricey but worth it”
Anti-Aging Benefits Sometimes Noted
- “softens fine lines”
- “boosts collagen production”
- “skin looks younger”
- “diminished wrinkles”
Fast Visible Results Sometimes Noted
- “results within a couple of days”
- “woke up and skin looked rested”
- “immediate results”
- “overnight difference”
Intense Tingling Sensation Sometimes Noted
- “burns a little”
- “strong tingle at first”
- “stings upon application”
- “sensation was too much”
Drying for Some Rarely Noted
- “can be drying”
- “need a good moisturizer after”
- “skin felt tight”
- “flaking around nose”
Risk of Counterfeits Rarely Noted
- “received fake product”
- “color was yellow not clear”
- “smelled different than usual”
- “bottle looked off”
Sources: lovi.care, lovelyskin.com, dermstore.com, walmart.com, brainsstreet.com.au, and more
Questions and answers
How well does iS Clinical Active Serum work for sensitive skin?
iS Clinical Active Serum works moderately well for sensitive skin, offering gentle exfoliation and hydration with willow bark extract to help calm redness and irritation. Treatments that fit sensitive skin better need soothing ingredients like niacinamide, snail secretion filtrate, and antioxidants to comfort the skin without any risk of irritation.
Which ingredients make this serum a good fit for sensitive skin?
Glycerin and willow bark extract make this serum a fit for sensitive skin by offering mild hydration and helping to calm redness and irritation. Glycerin helps maintain skin moisture, while willow bark extract supports a comfortable feel.
What does Sugarcane Extract do for sensitive skin?
What does Bilberry Fruit Extract do for sensitive skin?
Bilberry fruit extract is a gentle addition that helps calm sensitive skin and boost antioxidant protection. This ingredient is unlikely to cause irritation and may help improve overall skin health and smoothness.
Where does it go in a skincare routine for sensitive skin?
Apply this treatment in the evening, starting once a week to see how your skin reacts. This product of this type needs gentle exfoliating ingredients and soothing hydrators to keep your skin smooth and calm.
Can I use this serum with retinol, and in what order?
You can use this treatment with retinol by applying your retinol first, waiting for it to absorb, and then following with this serum. This product is unlikely to cause irritation on sensitive skin, though sensitive skin generally benefits more from products that prioritize soothing hydration and gentle barrier support without strong active acids.
How often should I use it?
You can use this treatment once a week in the evening, and if your sensitive skin tolerates it well without irritation, you may carefully use it more often. This product provides moderate exfoliation and hydration, but sensitive skin needs a product that prioritizes gentle, deeply calming ingredients and barrier-supporting hydrators.
Can this serum clog pores, cause breakouts or purging for sensitive skin?
This serum is safe and unlikely to clog pores or cause breakouts for sensitive skin because it lacks harsh ingredients, but it may cause an intense tingling sensation and needs extra soothing ingredients to fit this skin best.
Is it fragrance-free and alcohol-free?
It has no fragrance and contains drying alcohol (alcohol denat).
What the research says
A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Repeated short-contact 70% glycolic acid peels provided superior results in atrophic acne scars compared to daily low-strength glycolic acid cream or placebo in 58 women over 24 weeks.
International Journal of Dermatology, 2000Fermented bilberry extract improved wrinkle depth, skin smoothness, roughness, firmness, elasticity, antioxidant capacity, and complexion evenness compared to a placebo in 66 subjects over 84 days.
Nutrients, 2024Topical application of oil-in-water creams containing wild bilberry leaves extract and seeds oil produced significant beneficial effects on the skin of healthy human volunteers.
Antioxidants, 2021Bilberry fruit extract incorporated into chitosan-based hydrogels demonstrated antioxidant, anti-hyaluronidase, and anti-tyrosinase activities, supporting their potential use in topical anti-aging preparations.
Antioxidants, 2024A non-hydroquinone topical formulation (SKNB19) improved hyperpigmentation by 28.5% in patient self-assessment and 27% in independent reviewer assessment compared with 4% hydroquinone in 18 adult subjects, while showing significantly less irritation and better tolerability.
Journal of Cosmetic Science, 2020Encapsulation of alpha arbutin in an optimized ethosomal gel significantly improved skin melanin reduction, moisture content, and elasticity in human volunteers compared to conventional formulations.
Heliyon, 2023Combining a home-based radiofrequency device and arbutin cream reduced mMASI scores by 25.6% and melanin index by 22.8% at 8 weeks compared to baseline in 38 participants.
Journal of Cosmetic Dermatology, 2025A botanical face cleanser with hops and willow bark extract continuously reduced skin sebum levels without reactive seborrhea after treatment in 21 healthy volunteers compared to a sodium laureth sulfate cleanser, with neither cleanser causing skin irritation.
Journal of Cosmetic Dermatology, 2019Bioactive lipid nanocarriers co-loaded with willow bark or ivy leaf extracts and UV-filters provided pronounced UVA photoprotection up to an SPF-equivalent value of 13 and a maximum in vivo skin hydration effect of 97% when prepared with pomegranate oil.
Nanomaterials, 2022A topical serum containing 0.5% salicin applied twice daily reduced visible signs of skin aging, including wrinkles and tactile roughness, in 30 female subjects over 12 weeks compared to baseline.
Journal of Cosmetic Dermatology, 2010White button mushroom extract treatment increased VEGF densities, EGF, PCNA, and collagen fibers, while decreasing apoptotic cells and limiting TGF-beta and CD4 reactions in ICR mice and chorioallantoic culture, indicating beneficial effects on skin regeneration and injury.
Microscopy Research and Technique, 2012
Ingredients
Water, Glycerin, Butylene Glycol, Alcohol Denat, Saccharum Officinarum Extract, Vaccinium Myrtillus Leaf Extract Fruit, Triethanolamine, Willow Bark Extract, Glyceryl Polyacrylate, Arbutin, Polyporus Umbellatus Extract Mushroom Extract, Menthol, Phenoxyethanol
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
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Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Specialist dermatologist, MBBS, MD, IFAAD
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Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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