Dermalogica Multivitamin Power Firm for mature skin
Palmitoyl Hexapeptide-C14
Ascorbyl Glucoside
Retinyl Palmitate
Tocopherol- Magnesium Ascorbyl Phosphate
High
- HighNormal Skin Fit
- HighEffectiveness
- HighSafety
One of the best serums for mature skin.
This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Highly suitable for your normal skin, this product effectively targets wrinkles and fine lines with hydroxypinacolone retinoate and Palmitoyl Hexapeptide-C14 to boost collagen synthesis and skin renewal.
- Ascorbyl glucoside and retinyl palmitate further enhance antioxidant protection and collagen stimulation, complementing the primary anti-aging benefits.
- The formulation is safe for your skin, containing no harsh ingredients and posing no risk of irritation.
How to apply
- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
People Say
★4.6Overall rating based on 300+ reviewsUsers with mature or dry skin frequently praise this product for its velvety, silicone-based texture that instantly smooths fine lines and acts as an exceptional primer for concealer. While many report visible firming and improved elasticity, some reviewers find the high price point hard to justify and others experienced no significant long-term reduction in deep wrinkles.
Highlights
Silky texture Mostly Mentioned
- “feels like velvet”
- “glides on effortlessly”
- “soft silky texture”
- “not greasy”
Makeup primer Often Mentioned
- “great makeup prep”
- “concealer goes on nicer”
- “prevents concealer caking”
- “smooth base”
Expensive product Often Mentioned
- “way too expensive”
- “pricey”
- “investment”
- “cost prohibitive”
Firms and smooths Sometimes Noted
- “softens fine lines”
- “skin is firmer”
- “fills out wrinkles”
- “improves elasticity”
Pleasant scent Sometimes Noted
- “smells like sweets”
- “refreshing citrus scent”
- “smells lovely”
- “fruity fragrance”
Causes irritation Rarely Noted
- “irritating to eyes”
- “caused redness”
- “sting or burn”
- “watery eyes”
Lack of results Rarely Noted
- “didn't notice change”
- “no dramatic results”
- “didn't help wrinkles”
- “average moisturizer”
Not hydrating Rarely Noted
- “not hydrating enough”
- “need extra moisturizer”
- “sat on top of skin”
Sources: lovi.care, dermalogica.com, dermstore.com, lovelyskin.com, sephora.com, ulta.com, and more
Questions and answers
What makes Dermalogica Multivitamin Power Firm a great fit for mature skin?
Dermalogica Multivitamin Power Firm is a great fit for mature skin because it targets wrinkles and fine lines using hydroxypinacolone retinoate and Palmitoyl Hexapeptide-C14 to help boost collagen and skin renewal. Ascorbyl glucoside and retinyl palmitate provide extra antioxidant protection, and the formula is safe and unlikely to cause irritation.
Journal of Cosmetic Dermatology, 2025Journal of Cosmetic Dermatology, 2023
Which ingredients make this cream a good fit for mature skin?
Hydroxypinacolone retinoate and Palmitoyl Hexapeptide-C14 make this cream a great fit because they boost collagen and smooth out fine lines on mature skin. Ascorbyl glucoside and retinyl palmitate add extra antioxidant protection and help keep the skin looking firm and youthful.
Journal of Cosmetic Dermatology, 2025Journal of Cosmetic Dermatology, 2023
What does Palmitoyl Hexapeptide-C14 do for mature skin?
Palmitoyl Hexapeptide-C14 helps improve mature skin by triggering signaling pathways that encourage collagen production and boost skin hydration and brightness. It may also help reduce the look of wrinkles and support overall skin firmness and youthfulness. A product for mature skin needs ingredients like peptides, amino acids, and other nourishing factors to help rebuild strength, smooth the surface, and keep the skin feeling soft and supple.
Frontiers in Medicine, 2026Current Protein & Peptide Science, 2021
What does Ascorbyl Glucoside do for mature skin?
Ascorbyl Glucoside helps mature skin by smoothing out wrinkles, fading dark spots, and brightening an uneven complexion. It also supports firm, youthful skin by encouraging collagen growth and protecting against everyday damage.
Journal of Drugs in Dermatology, 2016The Journal of Nutrition, 1992
Where does this cream go in a skincare routine for mature skin?
This treatment goes in the evening routine after cleansing and before moisturizing. Putting this product in the evening step helps keep application simple and gives extra safety around sun exposure.
Can I use this cream with retinol, and in what order?
You can use this cream alongside a retinol product, but it is best to apply them on alternate nights to lower the risk of dryness or irritation.
How often should I use this cream?
Use this treatment in your evening routine, applying it after your cleansing toner and before your moisturizer. It is safe for regular use to help smooth fine lines and boost skin renewal.
Journal of Cosmetic Dermatology, 2025Journal of Cosmetic Dermatology, 2023
Can this cream clog pores, cause breakouts or purging for mature skin?
This cream is unlikely to clog pores, cause breakouts, or lead to purging on mature skin. It features a safe formulation with no harsh ingredients, minimizing the risk of irritation while targeting fine lines.
Is this cream fragrance-free and alcohol-free?
It has no drying alcohol and contains fragrance (limonene).
What the research says
A topical serum containing hydroxypinacolone retinoate and peptides used twice daily for 16 weeks achieved parity or statistically significantly better improvement in facial aging parameters compared to a single fractional CO2 laser treatment in women with moderate global photodamage.
Journal of Cosmetic Dermatology, 2025Hydroxypinacolone retinoate and retinyl propionate at a 5:9 weight ratio synergistically enhanced antiaging gene expressions in vitro and improved skin wrinkles, smoothness, transepidermal water loss, and elasticity in 42 Chinese urban women over an 8-week period without adverse reactions compared to retinol.
Journal of Cosmetic Dermatology, 2023A vitamin A palmitate and antioxidant-containing oil-based moisturizer improved fine lines, wrinkles, pigmentation, tone, texture, dryness, firmness, and clarity across various body sites compared to a no-treatment group over 12 weeks.
Journal of Cosmetic Dermatology, 2013Retinyl palmitate-loaded non-ionic lamellar liquid crystalline systems provided a significant reduction of orbicular wrinkles in human volunteers compared to systems without retinyl palmitate.
Colloids and Surfaces. B, Biointerfaces, 2011Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers.
Experimental Dermatology, 2003Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation.
Journal of Periodontology, 2009Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream.
Journal of Cosmetic Dermatology, 2022Over-the-counter retinol products provided only weak evidence for a mild ameliorating effect on fine facial skin wrinkle lines in randomized, double-blind, vehicle-controlled trials, and major methodological flaws call the validity of positive results into question.
The Journal of Clinical and Aesthetic Dermatology, 2021A cosmetic niacinamide/peptide/retinyl propionate regimen significantly improved periorbital wrinkle appearance relative to a 0.02% tretinoin regimen at 8 weeks with comparable benefits at 24 weeks, while demonstrating significantly better tolerability in 196 women.
The British Journal of Dermatology, 2010A novel triple-active cosmetic formulation containing 4-hexylresorcinol, retinyl propionate, and niacinamide improved the visual appearance of photoageing similarly to 0.02% tretinoin and reversed a consensus gene signature associated with ageing in female adults while causing less skin irritation.
International Journal of Cosmetic Science, 2024Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls.
Journal of Cosmetic Dermatology, 2025Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate.
Contemporary Clinical Trials Communications, 2021Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin.
Journal of Cosmetic Dermatology, 2024
Ingredients
Cyclopentasiloxane, Helianthus Annuus Seed Oil Sunflower Seed Oil, Glyceryl Dibehenate, Tricaprylin, Tribehenin, Glycerin, Silica, Nylon-12, Ascorbyl Glucoside, Boron Nitride, Magnesium Ascrobyl Phosphate, Hydrogenated Phosphatidyl Choline, Palmitoyl Hexapeptide-C14, Grapefruit Peel Oil, Citrus Aurantium Dulcis Peel Oil, Hydrogenated Soybean Oil, Alba Cera, Tocopherol, Retinyl Palmitate, Linoleic Acid, Beta-Sitosterol, Hydroxypinacolone Retinoate, Stearoxymethicone Dimethicone Copolymer, Dimethyl Isorbide, Dimethicone, Polysilicone-11, Glyceryl Stearate, Tocopheryl Acetate, Oil, Caprylic Capric Triglyceride, Lecithin, Butylene Glycol, Ethoxydiglycol, Water, Limonene
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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