Perricone MD Cold Plasma Plus+ Sub-D/Neck for mature skin
Dmae
Niacinamide
Tetrahexyldecyl Ascorbate
Acetyl Tetrapeptide-9
Glycerin
Superior
- SuperiorNormal Skin Fit
- SuperiorEffectiveness
- ExcellentSafety
One of the best sunscreens for mature skin.
This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Excellent suitability for your normal skin is provided by niacinamide and tetrahexyldecyl ascorbate, which offer antioxidant activity and melanogenesis regulation, complementing the targeted benefits for wrinkles and fine lines from Tetrahexyldecyl Ascorbate and Acetyl Tetrapeptide-9 that promote collagen synthesis and skin firming.
- Dimethicone and ethylhexyl methoxycrylene offer excellent moisturizing and sun protection, further enhancing the product's overall efficacy for your skin concerns.
- The safety profile is excellent, with no risks of irritation for your normal skin due to the absence of harsh ingredients and the presence of soothing ingredients like Bisabolol.
How to apply
- Apply this moisturizing sunscreen daily in your AM routine. Reapply every two hours if you are staying outdoors.
- Use this product as the final step in your morning routine after applying your moisturizer.
- Smooth an even layer over your face and neck, making sure to avoid rubbing too hard.
- Apply this moisturizing sunscreen on completely dry skin after your moisturizer has fully absorbed.
- Avoid direct contact with your eyes and do a patch test before your very first use.
People Say
★4.3Overall rating based on 2.2k+ reviewsBased on a very large amount of data, users frequently report visible improvements in skin texture and firmness along the jawline and neck, describing the skin as smoother and more hydrated. A significant number of reviewers consistently complain about a strong, unpleasant scent often compared to pickles or fish, and some experience issues with the product pilling under makeup.
Highlights
Unpleasant smell Mostly Mentioned
- “smells like pickles”
- “fishy odor”
- “scent is unbearable”
- “funky chemical smell”
Improves skin texture Often Mentioned
- “crepiness is gone”
- “skin feels smoother”
- “softens neck lines”
- “texture is refined”
Visibly tightens and firms Often Mentioned
- “jawline looks more defined”
- “helped with sagging skin”
- “tightened my turkey neck”
- “noticed firmness in weeks”
Hydrating formula Sometimes Noted
- “very moisturizing”
- “skin feels hydrated”
- “plumps the skin”
- “great for dry neck”
Lightweight and absorbent Sometimes Noted
- “absorbs quickly”
- “not greasy”
- “lightweight consistency”
- “sinks right in”
High price point Sometimes Noted
- “too expensive”
- “pricey for the amount”
- “not worth the money”
- “cost is prohibitive”
Caused irritation Rarely Noted
- “broke my neck out”
- “caused red rash”
- “skin felt burning”
- “itchy reaction”
Pilling or flaking Rarely Noted
- “rolls off skin”
- “flakes when touched”
- “pills under makeup”
- “residue rubs off”
Sources: lovi.care, perriconemd.com, nordstrom.com, macys.com, ulta.com, dermstore.com, and more
Questions and answers
What makes Perricone MD Cold Plasma Plus+ Sub-D/Neck one of the best fits for mature skin?
This product is one of the best fits for mature skin because it combines ingredients like niacinamide and tetrahexyldecyl ascorbate to protect against damage while smoothing out wrinkles and fine lines. It also provides deep moisture and sun protection to keep your skin looking firm and healthy.
Which ingredients make this cream a good fit for mature skin?
Tetrahexyldecyl ascorbate and acetyl tetrapeptide-9 make this cream a great fit because they help firm the skin and smooth out lines, while niacinamide helps brighten it. Dimethicone also keeps the skin soft and moisturized, and bisabolol helps keep it calm and comfortable.
What does DMAE do for mature skin?
DMAE helps make mature skin feel firmer and smoother while lessening the look of fine lines and wrinkles. Daily use of this ingredient is generally safe and supports a more youthful appearance over time, though it is unlikely to change your skin's basic mechanical properties.
American Journal of Clinical Dermatology, 2005Die Pharmazie, 2009
What does Niacinamide do for mature skin?
Niacinamide helps mature skin by smoothing out fine lines and wrinkles, reducing dark spots, and improving overall skin elasticity. It is also very well tolerated and supports a strong skin barrier to keep skin looking healthy.
Where does this cream go in a skincare routine for mature skin?
This cream goes in the morning routine as a moisturizer and sunscreen step. It helps keep skin soft and protected while smoothing fine lines.
The Journal of Dermatological Treatment, 2022Journal of Drugs in Dermatology, 2023
Can I use this cream with retinol, and in what order?
You can use this cream alongside retinol by applying the moisturizer during your morning routine as an SPF step, or by using it after your treatment in the evening. Using a moisturizing product alongside retinol helps support the skin barrier and reduces the likelihood of irritation during treatment.
How often should I use this cream?
You can use this moisturizing spf every morning as the final step of your daytime routine. Using it daily helps protect your skin from the sun while keeping it smooth and firm.
Journal of Cosmetic Dermatology, 2020Journal of Drugs in Dermatology, 2015
Can this cream clog pores, cause breakouts or purging for mature skin?
This cream is unlikely to cause irritation or breakouts on mature skin, thanks to a very safe formula that avoids harsh ingredients and includes soothing bisabolol.
Is this cream fragrance-free and alcohol-free?
It has no drying alcohol and contains fragrance (benzyl alcohol).
What the research says
Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer.
The British Journal of Dermatology, 2002Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Daily application of 3% DMAE facial gel for 16 weeks safely and efficaciously mitigates forehead lines and periorbital fine wrinkles, improves lip shape and fullness and overall aging skin appearance, and increases skin firmness compared to placebo.
American Journal of Clinical Dermatology, 2005A gel containing 3% 2-dimethylaminoethanol (DMAE) increased skin firmness, demonstrated by increased shear wave velocity in 30 volunteers compared to a formulation without DMAE.
Skin Research and Technology, 2002A DMAE-based formulation increased dermal and collagen fiber thickness in hairless mice and enhanced stratum corneum water content in human forearm skin compared to control formulations, without significantly modifying mechanical properties.
Die Pharmazie, 2009Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline.
Journal of Cosmetic and Laser Therapy, 2006Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers.
Experimental Dermatology, 2003Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation.
Journal of Periodontology, 2009Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream.
Journal of Cosmetic Dermatology, 2022A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.
Journal of Cosmetic Dermatology, 2020Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.
International Journal of Cosmetic Science, 2001
Ingredients
Water, Dimethicone, Cyclopentasiloxane, Glycerin, Niacinamide, Ethylhexyl Methoxycrylene, Pentylene Glycol, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Polyester-8, Polyglyceryl-3 Polydimethylsiloxyethyl Dimethicone, Tetrahexyldecyl Ascorbate, Thioctic Acid, Acetyl Tetrapeptide-9, Diethylhexyl Syringylidenemalonate, Hydrogenated Lecithin, Bisabolol, Xanthan Gum, Hydrogenated Phosphatidylcholine, Mannitol, Benzyl Alcohol, Stearic Acid, Isohexadecane, Polysilicone-11, Polysorbate 60, Sorbitan Isostearate, Caprylic Capric Triglyceride, Phenoxyethanol, Potassium Sorbate, Sodium Benzoate, Aluminum Hydroxide
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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