Lancôme Rénergie H.P.N. 300-Peptide Cream for acne-prone skin
Peptides
Sodium Hyaluronate
Niacinamide
Hydrolyzed Lupine Protein
Adenosine
Average
- AverageCombination Skin Fit
- AverageEffectiveness
- HighSafety
Works for acne-prone skin; other moisturizers fit it better.
This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate moisturizing and treatment for your combination skin, as glycerin and hydrolyzed hyaluronic acid provide hydration and plumping effects, though it lacks specialized ingredients to directly target acne and breakouts.
- Tocopherol offers some soothing benefits, which is supportive for your skin concerns, but the formula does not provide optimal oil control for your oily areas.
- The product is safe for your combination skin with no risks of irritation due to the absence of prohibited or harsh ingredients.
How to apply
- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help keep breakouts under control.
- Apply after your cleanser and toner, and make sure to use your SPF right after in the morning.
- Gently spread a small amount of moisturizer over your face using soft motions. Let it absorb into the skin for a minute before getting dressed or applying makeup.
- Apply on slightly damp skin to help lock in extra moisture. This keeps your combination skin balanced without feeling heavy.
- Avoid the eye area and do a patch test before your first use. Stop using if you feel any irritation.
People Say
★4.7Overall rating based on 7.1k+ reviewsBased on a very large amount of data, this rich cream is highly recommended for mature and dry skin, effectively plumping, firming, and smoothing without greasiness, leading to a radiant complexion. Some users noted sensitivity to the fragrance and found the price to be high.
Highlights
Luxurious non-greasy texture Mostly Mentioned
- “rich cream that absorbs instantly”
- “feels like butter but not oily”
- “sinks in beautifully”
- “perfect under makeup”
Deep hydration Often Mentioned
- “skin feels hydrated all day”
- “no more dry patches”
- “leaves face feeling soft”
- “plumps up dehydration lines”
Visible anti-aging results Often Mentioned
- “jawline looks tighter”
- “fine lines are less visible”
- “skin feels plumper”
- “texture is much smoother”
High price point Often Mentioned
- “very expensive for the amount”
- “hard to justify the cost”
- “price is a bit steep”
- “wish it was more affordable”
Pleasant fragrance Sometimes Noted
- “smells absolutely divine”
- “light and fresh scent”
- “fragrance is lovely but not overpowering”
- “luxurious spa smell”
Refillable packaging Sometimes Noted
- “love that it is refillable”
- “beautiful heavy glass jar”
- “great sustainable option”
- “easy to replace the pod”
Heavy for oily skin Rarely Noted
- “too heavy for my oily zone”
- “made me look greasy”
- “clogged my pores”
- “better for night use only”
Lack of dramatic results Rarely Noted
- “didn't see a difference”
- “just a basic moisturizer”
- “not enough for very dry skin”
- “expected more for the price”
Skin irritation Rarely Noted
- “caused a red rash”
- “skin felt burning”
- “broke me out in hives”
- “irritated my sensitive skin”
Strong fragrance Rarely Noted
- “fragrance is too heavy”
- “smell lingers too long”
- “perfume irritated my eyes”
- “wish it was fragrance-free”
Sources: lovi.care, macys.com, ulta.com, lancome-usa.com, walmart.com, sephora.com, and more
Questions and answers
How well does Lancôme Rénergie H.P.N. 300-Peptide Cream work for acne-prone skin?
Lancome Renergie H.P.N. 300-Peptide Cream works reasonably well for acne-prone skin, as it offers moderate hydration and soothing benefits without any irritation, though other products fit this skin type better. To work best for acne-prone skin, a product of this type needs specialized ingredients to directly target breakouts and provide oil control for oily areas.
Which ingredients make this cream a good fit for acne-prone skin?
Glycerin, hydrolyzed hyaluronic acid, and tocopherol make this cream a good fit for acne-prone skin by providing hydration and soothing benefits. However, because it lacks specialized ingredients to directly target acne and breakouts and does not provide optimal oil control, a product of this type needs acne-fighting ingredients, oil-controlling agents, and soothing extracts to truly fit this skin.
What do Peptides do for acne-prone skin?
Peptides help calm acne-prone skin by reducing redness and soothing inflammation while supporting the skin barrier. Certain advanced peptide formulas also work to target acne-causing bacteria and help balance oil production.
Biochemical Pharmacology, 2025Bioresources and Bioprocessing, 2026
What does Hyaluronic Acid do for acne-prone skin?
Hyaluronic acid helps acne-prone skin by soothing irritation, calming redness, and keeping the skin balanced without clogging pores. When combined with targeted ingredients like zinc oxide, it may also help reduce breakouts.
Where does this cream go in a skincare routine for acne-prone skin?
This moisturizing treatment goes near the end of your morning and evening routines, right before sunscreen in the morning and as your final step at night. While it provides good hydration, acne-prone skin works best with products that also include targeted breakout-clearing ingredients and oil control.
Can I use it with retinol, and in what order?
You can use this moisturizing treatment with retinol by applying it after your retinol to help soothe dryness and keep your skin soft. This product type works well for acne-prone skin when it includes ingredients that clear blemishes and balance oil.
How often should I use this cream?
You can use this moisturizing treatment twice daily as part of your morning and evening routine. Regular daily application helps improve skin moisture and barrier function.
Journal of Cosmetic Dermatology, 2020Health Science Reports, 2021
Can it clog pores, cause breakouts or purging for acne-prone skin?
This cream is unlikely to cause irritation on your skin, but it does not provide optimal oil control for your acne-prone areas. A product for this skin needs specialized ingredients to directly target breakouts and help balance oil.
Can I use this cream around the eyes or on my body?
This moisturizing treatment is generally safe to use on the body and around the eyes, as its gentle formula lacks harsh ingredients that typically cause irritation. However, because skin is much thinner around the eyes and varies in thickness across the body, results may differ compared to facial application.
Is it fragrance-free and alcohol-free?
It contains fragrance (benzyl alcohol, geraniol, limonene, and parfum) and drying alcohol (alcohol denat).
What the research says
A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.
Journal of Drugs in Dermatology, 2011Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.
Clinical Oral Investigations, 2022Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.
BMC Oral Health, 2019Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months.
The Journal of Dermatology, 2008Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants.
International Journal of Molecular Sciences, 2026Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts.
International Journal of Molecular Sciences, 2021
Why other moisturizers fit acne-prone skin better
Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components.
Molecules, 2023A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions.
Journal of Cosmetic Dermatology, 2024A facial serum containing snail secretion filtrate, Calendula officinalis, and Glycyrrhiza glabra root extract significantly reduced inflammatory acne lesions compared to placebo in 66 participants with mild-to-moderate maskne over 12 weeks.
Journal of Cosmetic Dermatology, 2022
Ingredients
Water, Glycerin, Dimethicone, Cetearyl Alcohol, Theobroma Grandiflorum Seed Butter, Alcohol Denat, Cetearyl Isononanoate, Niacinamide, Glyceryl Stearate, Peg-100 Stearate, Isopropyl Palmitate, Octyldodecanol, Cyclodextrin, Hydrolyzed Lupine Protein, Pisum Sativum Extract, Adenosine, Capryloyl Salicylic Acid, Hydrolyzed Hyaluronic Acid, Hydrolyzed Linseed Extract, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Trisodium Ethylenediamine Disuccinate, Tocopheryl Acetate, Alba Cera, Beeswax, Cire Dabeille, Orbignya Oleifera Seed Oil, Jojoba Butter, Cetearyl Glucoside, Citric Acid, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Polysorbate 60, Potassium Cetyl Phosphate, Sorbitan Isostearate, Tocopherol, Dimethicone Polyglycerin-3 Crosspolymer, Benzyl Alcohol, Geraniol, Limonene, Chlorphenesin, Dipropylene Glycol, Phenoxyethanol, Sodium Benzoate, Parfum
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
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