Lancôme Advanced Génifique Night Cream for dry skin
Bifida Lysate Ferment
Adenosine
Sodium Hyaluronate
Ceramide Np
Ascorbyl Glucoside
High
- AverageDry Skin Fit
- HighEffectiveness
- HighSafety
One of the best moisturizers for dry skin.
This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate hydration for your dry or flaky skin due to the presence of glycerin and sodium hyaluronate, which provide general skincare benefits. Bifida ferment lysate and sodium hyaluronate enhance barrier resilience and offer excellent moisturizing properties.
- The formula contains humectant ingredients like glycerin and sodium hyaluronate that attract moisture to the skin, but it lacks sufficient emollient and occlusive ingredients for optimal hydration for dry skin.
- The safety profile is excellent, with no risks of irritation for your dry skin due to the absence of prohibited or harsh ingredients and the presence of soothing ingredients like Bifida Lysate Ferment and Sodium Hyaluronate.
How to apply
- Could be used as part of your AM or PM routine. Start using it 3 times a week and work your way up to daily use.
- Apply your moisturizer after your toner and before your sunscreen in the morning. At night, use it as the final step after your serum.
- Gently press a small amount of the moisturizer into your skin. Avoid rubbing to keep your dry skin happy.
- Apply the moisturizer on slightly damp skin to help lock in extra hydration. This is great for soothing dry and flaky areas .
- Avoid the sensitive eye area and do a patch test before your first use .
People Say
★4.7Overall rating based on 2.7k+ reviewsBased on a very large amount of data, this product is highly regarded for its ability to deeply hydrate dry and aging skin, effectively repair the moisture barrier, and leave the complexion feeling plump, smooth, and radiant by morning. It is frequently noted for reducing the appearance of fine lines and smoothing the skin texture. While most users find it absorbs quickly without a greasy feel, a small number of individuals with sensitive skin have reported experiencing breakouts or irritation, and some dislike the fragrance.
Highlights
Deeply hydrating Mostly Mentioned
- “The product provides deep hydration and visible rejuvenation.”
- “Skin feels softer, smoother, and more hydrated.”
- “Leaves skin moisturized and glowing.”
- “Thick and moisturizing.”
Absorbs quickly Often Mentioned
- “Doesn't have an oil feeling it's very light.”
- “Absorbs quickly and leaves skin feeling refreshed without feeling greasy.”
- “Thicker cream that does not make face feel greasy.”
- “Does not leave the skin feeling sticky.”
Softens and smooths Often Mentioned
- “Face is so soft, smooth and not puffy.”
- “Goes on smoothly and makes skin feel like butter.”
- “Skin feels softer, smoother, and more hydrated.”
- “Leaves the skin feeling softer, smoother, and more radiant.”
Reduces fine lines Sometimes Noted
- “Helps with wrinkles and makes skin soft.”
- “Noticed a difference with the crows feet around my eyes.”
- “Helps reduce the appearance of fine lines and wrinkles.”
- “Reduces the appearance of fine lines and wrinkles, to leave skin looking youthful.”
Causes breakouts Rarely Noted
- “Caused swelling and breakouts.”
- “Had a few pimples that I didn't have before.”
- “Did have one pimple below my eye.”
- “Tiny pimples (bumps) on my jaw line and above my brows.”
Skin irritation Rarely Noted
- “Started burning my face.”
- “Smells very bad and itchy.”
- “Caused swelling and breakouts.”
- “Afraid to use it because it made me wonder what is in it.”
Unpleasant smell Rarely Noted
- “Smells terrible, similar to hair bleach.”
- “Smells like old sunscreen.”
- “Smells very bad.”
- “Disliked the fragrance.”
Sources: lovi.care, macys.com, lookfantastic.com, ulta.com, lancome-usa.com, nordstromrack.com, and more
Questions and answers
What makes Lancôme Advanced Génifique Night Cream a great fit for dry skin?
This cream is a great fit because it provides moderate moisture and strengthens your skin barrier using ingredients like glycerin, sodium hyaluronate, and Bifida Lysate Ferment. It also has an excellent safety profile with soothing ingredients that are very unlikely to irritate dry skin.
Clinical, Cosmetic and Investigational Dermatology, 2017Journal of Cosmetic Dermatology, 2023
Which ingredients make this cream a good fit for dry skin?
Lancome Advanced Genifique Night Cream is a great fit for dry skin because it contains sodium hyaluronate, glycerin, and ceramides that help draw in moisture and strengthen the skin barrier. It also features soothing ingredients like bifida ferment lysate and adenosine that are unlikely to cause irritation.
What does Bifida Ferment Lysate do for dry skin?
Bifida Ferment Lysate helps dry skin by strengthening the skin barrier and keeping it well hydrated. It also helps calm irritation and protects against everyday stress.
Journal of Cosmetic Dermatology, 2023Scientific Reports, 2023
What does Adenosine do for dry skin?
Adenosine helps dry skin by boosting hydration and reducing dryness, roughness, and wrinkles. It modulates skin biological mechanisms to improve overall moisture and texture.
International Journal of Cosmetic Science, 2018Journal of Cosmetic Dermatology, 2019
Where does this cream go in a skincare routine for dry skin?
This treatment goes in the evening routine after cleansing and before your moisturizer. It is unlikely to cause irritation on dry skin due to its soothing ingredients.
Can I use this cream with retinol, and in what order?
You can use this cream with retinol, and applying it either before or after retinol helps keep your dry skin calm and comfortable. This cream is unlikely to cause irritation due to the absence of harsh ingredients and the presence of soothing components.
How often should I use this cream?
You can use this moisturizing treatment in your evening routine, applying it after cleansing. Daily application helps improve skin moisture and supports the skin barrier while carrying a very low risk of irritation.
Can this cream clog pores, cause breakouts or purging for dry skin?
This cream is unlikely to cause breakouts or clog pores on dry skin, as it has a very safe formula with soothing ingredients and low complaints of breakouts from reviewers.
Can I use this cream around the eyes or on my body?
You can use this cream on your body or around your eyes, as it has an excellent safety profile with soothing ingredients that are unlikely to irritate thin skin. However, because it only offers moderate hydration, dry skin on the body or eye area may need a richer product with more softening and sealing ingredients to stay fully smooth.
Is this cream fragrance-free and alcohol-free?
It has no drying alcohol and contains fragrance (linalool, limonene, citronellol, and parfum). Behenyl alcohol and cetyl alcohol are fatty alcohols, which soften the skin.
What the research says
A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Topical application of Bifida Ferment Lysate strengthens the skin barrier function by upregulating barrier and antimicrobial peptide genes, exhibiting strong antioxidant properties, and decreasing inflammatory cytokine secretion in vitro.
Journal of Cosmetic Dermatology, 2023Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months.
The Journal of Dermatology, 2008Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants.
International Journal of Molecular Sciences, 2026Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts.
International Journal of Molecular Sciences, 2021Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.
Journal of Drugs in Dermatology, 2011Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.
Clinical Oral Investigations, 2022Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.
BMC Oral Health, 2019Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers.
Experimental Dermatology, 2003Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation.
Journal of Periodontology, 2009Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream.
Journal of Cosmetic Dermatology, 2022
Ingredients
Water, Bifida Lysate Ferment, Glycerin, Dicaprylyl Ether, Pentylene Glycol, Polyglyceryl-6 Distearate, Propanediol, Cetyl Esters, Jojoba Esters, Ammonium Polyacryloyldimethyl Taurate, Behenyl Alcohol, Octyldodecanol, Acacia Decurrens Flower Cera, Acacia Decurrens Wax Flower, Helianthus Annuus Seed Cera, Sunflower Wax Seed, Helianthus Annuus Seed Oil, Sunflower Seed Oil, Polymnia Sonchifolia Root Juice, Ceramide Np, Alpha-Glucan Oligosaccharide, Sodium Hyaluronate, Sodium Hydroxide, Sodium Stearoyl Glutamate, Salicyloyl Phytosphingosine, 2-Oleamido-1, 3-Octadecanediol, Adenosine, Mannose, Coco-Caprylate Caprate, Ascorbyl Glucoside, Hydroxyacetophenone, Hydroxypalmitoyl Sphinganine, Hydroxypropyl Phosphate Starch, Capryloyl Salicylic Acid, Trisodium Ethylenediamine Disuccinate, Lactic Acid, Lactobacillus, Acetic Acid, Maltodextrin, Yeast Extract, Extrait De Levure, Polyglycerin-3, Polyglyceryl-3 Beeswax, Cetyl Alcohol, Tocopherol, Sodium Benzoate, Linalool, Limonene, Citronellol, Parfum
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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